Galápagos sea lion behavior differences in relation to human exposure

Our study examined the behavioral differences of the Galápagos sea lion (Zalophus wollebaeki) in relation to human presence. Our main goal was to determine whether sea lions would be more aggressive as a result of high frequencies of human exposure. We hypothesized that sea lions would behave differently in relation to varying rates of human exposure and we predicted that there would be more aggressive and interactive behaviors on beaches with higher frequencies of human exposure (as the humans may disturb the normal behavioral patterns of the sea lions). Data was collected daily at low tide in two-hour intervals. Our study took place during July 2014 on Isla San Cristóbal on three beaches near Puerto Baquerizo Moreno, Galápagos Islands, Ecuador. We recorded the number of people and sea lions on each beach during each data collection, as well as any observed behavioral characteristics of sea lions. We categorized behavioral characteristics of sea lions as aggressive, interactive but non-aggressive, and non-interactive both on terrestrial and aquatic environments. In addition, we accounted for the frequency of interactions in relation to the size of the beach in which data was collected. Results from a Chi-squared goodness of fit test showed that there was a significant difference in the sea lions’ behavior in relation to human exposure (p \u3c 0.0001). Further analysis showed that sea lions tend to be more aggressive in response to higher frequencies of human exposure (p \u3c 0.0001). Previous studies have shown that high rates of human exposure in sea lion habitats can result in a decrease of sea lion populations (French et al., 2011). With regards to these results, there should be a consideration for how human exposure can affect the behavior of sea lions. Tourism in the Galápagos Islands remains prevalent, which can potentially disrupt the natural behavior of protected species if humans disrupt the animals’ natural behavior

Is the Unadjusted ICU Mortality a Good Indicator of Quality of ICU Care?

info:eu-repo/semantics/publishedVersio

A comparative DFT study of electronic properties of 2H-, 4H- and 6H-SiC(0001) and SiC(000-1) clean surfaces: Significance of the surface Stark effect

Electric field, uniform within the slab, emerging due to Fermi level pinning at its both sides is analyzed using DFT simulations of the SiC surface slabs of different thickness. It is shown that for thicker slab the field is nonuniform and this fact is related to the surface state charge. Using the electron density and potential profiles it is proved that for high precision simulations it is necessary to take into account enough number of the Si-C layers. We show that using 12 diatomic layers leads to satisfactory results. It is also demonstrated that the change of the opposite side slab termination, both by different type of atoms or by their location, can be used to adjust electric field within the slab, creating a tool for simulation of surface properties, depending on the doping in the bulk of semiconductor. Using these simulations it was found that, depending on the electric field, the energy of the surface states changes in a different way than energy of the bulk states. This criterion can be used to distinguish Shockley and Tamm surface states. The electronic properties, i.e. energy and type of surface states of the three clean surfaces: 2H-, 4H-, 6H-SiC(0001), and SiC($000 \bar{1}$) are analyzed and compared using field dependent DFT simulations.Comment: 18 pages, 10 figures, 4 table

Transmission Distortion of MCT1 rs1049434 among Polish Elite Athletes

Background: To date, nearly 300 genetic markers were linked to endurance and power/strength traits. The current study aimed to compare genotype distributions and allele frequencies of the common polymorphisms: MCT1 rs1049434, NRF2 rs12594956, MYBPC3 rs1052373 and HFE rs1799945 in Polish elite athletes versus nonathletes. Methods: The study involved 101 male elite Polish athletes and 41 healthy individuals from the Polish population as a control group. SNP data were extracted from whole-genome sequencing (WGS) performed using the following parameters: paired reads of 150 bps, at least 90 Gb of data per sample with 300 M reads and 30x mean coverage. Results: All the analyzed polymorphisms conformed to Hardy-Weinberg equilibrium (HWE) in athletes and the control group, except the MCT1 rs1049434, where allele T was over-represented in the elite trainers' group. No significant between-group differences were found for analyzed polymorphisms. Conclusions: The MCT1 rs1049434 transmission distortion might be characteristic of Polish athletes and the effect of strict inclusion criteria. This result and the lack of statistically significant changes in the frequency of other polymorphisms between the groups might result from the small group size

Role of structure of C-terminated 4H-SiC(000) surface in growth of graphene layers - transmission electron microscopy and density functional theory studies

Principal structural defects in graphene layers, synthesized on a carbon-terminated face, i.e. the SiC(000) face of a 4H-SiC substrate, are investigated using microscopic methods. Results of high-resolution transmission electron microscopy (HRTEM) reveal their atomic arrangement. Mechanism of such defects creation, directly related to the underlying crystallographic structure of the SiC substrate, is elucidated. The connection between the 4H-SiC(000) surface morphology, including the presence of the single atomic steps, the sequences of atomic steps, and also the macrosteps, and the corresponding emergence of planar defective structure (discontinuities of carbon layers and wrinkles) is revealed. It is shown that disappearance of the multistep island leads to the creation of wrinkles in the graphene layers. The density functional theory (DFT) calculation results show that the diffusion of both silicon and carbon atoms is possible on a Si-terminated SiC surface at a high temperature close to 1600{\deg}C. The creation of buffer layer at the Si-terminated surface effectively blocks horizontal diffusion, preventing growth of thick graphene layer at this face. At the carbon terminated SiC surface, the buffer layer is absent leaving space for effective horizontal diffusion of both silicon and carbon atoms. DFT results show that excess carbon atoms converts a topmost carbon layer to sp2 bonded configuration, liberating Si atoms in barrierless process. The silicon atoms escape through the channels created at the bending layers defects, while the carbon atoms are incorporated into the growing graphene layers. These results explain growth of thick graphene underneath existing graphene cover and also the creation of the principal defects at the C-terminated SiC(0001) surfaceComment: 20 pages,11 figure

DEGRONOPEDIA:a web server for proteome-wide inspection of degrons

E3 ubiquitin ligases recognize substrates through their short linear motifs termed degrons. While degron-signaling has been a subject of extensive study, resources for its systematic screening are limited. To bridge this gap, we developed DEGRONOPEDIA, a web server that searches for degrons and maps them to nearby residues that can undergo ubiquitination and disordered regions, which may act as protein unfolding seeds. Along with an evolutionary assessment of degron conservation, the server also reports on post-translational modifications and mutations that may modulate degron availability. Acknowledging the prevalence of degrons at protein termini, DEGRONOPEDIA incorporates machine learning to assess N-/C-terminal stability, supplemented by simulations of proteolysis to identify degrons in newly formed termini. An experimental validation of a predicted C-terminal destabilizing motif, coupled with the confirmation of a post-proteolytic degron in another case, exemplifies its practical application. DEGRONOPEDIA can be freely accessed at degronopedia.com

The Archaeology of Hassanamesit Woods: The Sarah Burnee/Sarah Boston Farmstead

Between 2003 and 2013 the Fiske Center for Archaeological Research at the University of Massachusetts Boston conducted an intensive investigation of the Sarah Burnee/Sarah Boston Farmstead on Keith Hill in Grafton, Massachusetts. The project employed a collaborative method that involved working closely with the Town of Grafton, through the Hassanmesit Woods Management Committee, and the Nipmuc Nation, the state recognized government of the Nipmuc people. Yearly excavation and research plans were decided through consultation with both the Nipmuc Tribal Council, their designated representative, Dr. D. Rae Gould, and the Hassanamesit Woods Management Committee. Dr. Gould also played a continuous and active role in reviewing and collaborating on research activities including scholarly presentations at national and international academic meetings and public presentations at the community level. Large scale excavation between 2006 and 2013 focused on the Sarah Burnee/Sarah Boston farmstead that was occupied intensively between 1750 and 1840. Sarah Burnee and Sarah Boston were two of four Nipmuc women to own and possibly reside on the 206 acre parcel that today comprises Hassanamesit Woods. The other two, Sarah Robins and Sarah Muckamaug, were Sarah Burnee’s grandmother and mother respectively. Excavation, archaeogeophysical survey, soil chemistry, and micromorphological and macrobotanical analysis were combined with the analysis of material culture and faunal material to generate a detailed picture of Nipmuc life during the 18th and 19th centuries. Excavation also found evidence of earlier indigenous occupations spanning some 6,000 years. The most intensive period of occupation covered the period 1750 to 1840, but with a significant spike the period 1790 to 1830. This appears to coincide with the coming of age of Sarah Boston who continues to live in the household with her mother Sarah Burnee Philips. Based on a combination of the documentary, architectural and archaeological data, it seems that an addition was made the structure between 1799 and 1802. A rich material assemblage of more than 120,000 artifacts was recovered from the site that provides detailed information on cultural practices including foodways, exchange networks, agricultural activities and other work-related activities such as basket making. A wealth of foodways related artifacts as well as faunal and floral remains provide ample evidence of daily meals and feasting. The latter conclusion is particularly important because of the implications is has for demonstrating that the Hassanamisco Nipmuc were regularly engaged in political activities. We believe the findings of the project provide empirical evidence that counters arguments made by the Bureau of Indian Affairs that the Hassanamisco Nipmuc did not persist as a politically and culturally continuous community

DEGRONOPEDIA:a web server for proteome-wide inspection of degrons

E3 ubiquitin ligases recognize substrates through their short linear motifs termed degrons. While degron-signaling has been a subject of extensive study, resources for its systematic screening are limited. To bridge this gap, we developed DEGRONOPEDIA, a web server that searches for degrons and maps them to nearby residues that can undergo ubiquitination and disordered regions, which may act as protein unfolding seeds. Along with an evolutionary assessment of degron conservation, the server also reports on post-translational modifications and mutations that may modulate degron availability. Acknowledging the prevalence of degrons at protein termini, DEGRONOPEDIA incorporates machine learning to assess N-/C-terminal stability, supplemented by simulations of proteolysis to identify degrons in newly formed termini. An experimental validation of a predicted C-terminal destabilizing motif, coupled with the confirmation of a post-proteolytic degron in another case, exemplifies its practical application. DEGRONOPEDIA can be freely accessed at degronopedia.com

Morning concurrent track 3: Weathering climate change in the curriculum

MORNING CONCURRENT TRACK 3: WEATHERING CLIMATE CHANGE IN THE CURRICULUM Moderator Barbara St. Pierre Schneider Student Union Room 213 Andy Jorgensen – Creating a Learning Community for Solutions to Climate Change Abstract: The Climate Solutions Committee of the Council of Environmental Deans and Directors (CEDD) has proposed the creation of a learning community that will develop curricular content on solutions to anthropogenic climate change by drawing on the best available research on the phenomenon, coupled with the most effective pedagogical methods. The goal is to transform academic education about climate change from the current emphasis on physical and biological science to an interdisciplinary enterprise that includes mitigation and adaptation. We propose to use a community-building process to produce an adaptive virtual tool chest of curricular resources, methods, and experiences that can be used by educators at a variety of levels, focused on how to teach about climate solutions in general education and courses for science majors. The goal is to equip college students not just to diagnose problems but to give them the capacity to address and fix them. Amy Northrup, David Hassenzahl – Climate Education Courses in the United States Abstract: Climate change is becoming an increasingly common topic of courses at institutions of higher education across the United States. However, the literature on appropriate and effective climate education praxis is limited. This session will outline, presents early findings on, and solicit ideas about how best to proceed with, an evaluation of climate education courses and programs. The first stage of this research is the development of a database of climate education syllabi. It is a non non-random sample, but should represent the range of courses being offered, and can be used to assess what topics are being covered, at what institutions and program, and at what academic level . David James, Tom Piechota, Jeff Jablonski – Sustainability and General Education Abstract: The topics of sustainability, environmental literacy, and climate change are becoming part of many university educational programs. This presentation will present some of the national programs that are incorporating sustainability and the climate change. In addition, the presenters will give an update on the revisions being proposed to the UNLV General Education core, which may include incorporating sustainability into an educational outcome related to ethics and sustainability as dimensions of responsible citizenship

Secondary mtDNA defects do not cause optic nerve dysfunction in a mouse model of dominant optic atrophy

purpose. The majority of patients with autosomal dominant optic atrophy (DOA) harbor pathogenic OPA1 mutations and certain missense mutations, mostly within the GTPase domain, have recently been shown to cause multiple mitochondrial DNA (mtDNA) deletions in skeletal muscle. This raises the possibility that the optic neuropathy could be the result of secondary mtDNA defects accumulating within retinal ganglion cells (RGCs). To explore this hypothesis, the authors looked for evidence of mitochondrial dysfunction in a mouse model of DOA and documented the visual and neurologic progression in aging mutant mice. methods. Visual function was assessed with a rotating optokinetic (OKN) drum at ages 13 and 18 months and neurologic phenotyping was performed using the primary SHIRPA screen at age 13 months, comparing mutant Opa1+/− mice with wild-type C57Bl/6 mice. The presence of cytochrome c oxidase (COX) deficiency and multiple mtDNA deletions was investigated in gastrocnemius muscle and eye specimens harvested from 2- and 11-month-old Opa1+/+ and Opa1+/− mice. results. At age 13 months, Opa1+/− mice had a statistically significant reduction in OKN responses compared to C57Bl/6 controls with both 2° and 8° gratings (P < 0.001). At age 18 months, the difference between the two groups was significant for the 8° grating (P = 0.003) but not for the 2° grating (P = 0.082). Opa1+/− mice did not exhibit any significant neuromuscular deficits and no COX deficient areas or secondary mtDNA deletions were identified in skeletal muscle or the RGC layer. There was also no evidence of significant mtDNA depletion or proliferation in skeletal muscle from Opa1+/− mice. conclusions. COX deficiency and mtDNA abnormalities do not contribute to optic nerve dysfunction in pure DOA