Accuracy assessment of Tri-plane B-mode ultrasound for non-invasive 3D kinematic analysis of knee joints

BACKGROUND Currently the clinical standard for measuring the motion of the bones in knee joints with sufficient precision involves implanting tantalum beads into the bones. These beads appear as high intensity features in radiographs and can be used for precise kinematic measurements. This procedure imposes a strong coupling between accuracy and invasiveness. In this paper, a tri-plane B-mode ultrasound (US) based non-invasive approach is proposed for use in kinematic analysis of knee joints in 3D space. METHODS The 3D analysis is performed using image processing procedures on the 2D US slices. The novelty of the proposed procedure and its applicability to the unconstrained 3D kinematic analysis of knee joints is outlined. An error analysis for establishing the method's feasibility is included for different artificial compositions of a knee joint phantom. Some in-vivo and in-vitro scans are presented to demonstrate that US scans reveal enough anatomical details, which further supports the experimental setup used using knee bone phantoms. RESULTS The error between the displacements measured by the registration of the US image slices and the true displacements of the respective slices measured using the precision mechanical stages on the experimental apparatus is evaluated for translation and rotation in two simulated environments. The mean and standard deviation of errors are shown in tabular form. This method provides an average measurement precision of less than 0.1 mm and 0.1 degrees, respectively. CONCLUSION In this paper, we have presented a novel non-invasive approach to measuring the motion of the bones in a knee using tri-plane B-mode ultrasound and image registration. In our study, the image registration method determines the position of bony landmarks relative to a B-mode ultrasound sensor array with sub-pixel accuracy. The advantages of our proposed system over previous techniques are that it is non-invasive, does not require the use of ionizing radiation and can be used conveniently if miniaturized.This work has been supported by School of Engineering & IT, UNSW Canberra, under Research Publication Fellowship

Monuments and commemorations: a consideration

When William Charles Wentworth, the leading conservative politician in the colony of New South Wales, retired from public life in order to travel to Britain in 1853, he informed his devoted followers that he would ‘accept no testimonial except in the form of a colossal statue of his person to be placed in some very conspicuous part of Sydney’. According to the report in a hostile newspaper, Wentworth issued this demand so that ‘his countrymen might have an opportunity of perceiving how a grateful community could appreciate, reward and honour the services of any individual who devoted sincerely his talents and his leisure to the services of his fellow citizens’.

Constant angular velocity of the wrist during the lifting of a sphere.

The primary objective of the experiments was to investigate the wrist motion of a person while they were carrying out a prehensile task from a clinical hand function test. A sixcamera movement system was used to observe the wrist motion of 10 participants. A very light sphere and a heavy sphere were used in the experiments to study any mass effects. While seated at a table, a participant moved a sphere over a small obstacle using their dominant hand. The participants were observed to move their wrist at a constant angular velocity. This phenomenon has not been reported previously. Theoretically, the muscles of the wrist provide an impulse of force at the start of the rotation while the forearm maintains a constant vertical force on a sphere. Light–heavy mean differences for the velocities, absolute velocities, angles and times taken showed no significant differences (p¼0.05)

Conserving the people's history: lessons from Manchester and Salford

The closest that Margaret Thatcher comes to an admission of failure in her voluminous political memoirs concerns her efforts to promote history as a subject for school children. Ironically, however, one of the acknowledged legacies of the Thatcher years, a by-product of the transformation of the British economy from manufacturing to services under her stewardship, is the proliferation of museums and historical precincts that pepper the countryside from New Lanark to Wigan Pier

Taming the interoperability challenges of complex IoT systems

of communication protocols and data formats; hence ensuring diverse devices can interoperate with one another remains a significant challenge. Model-driven development and testing solutions have been proposed as methods to aid software developers achieve interoperability compliance in the face of this increasing complexity. However, current approaches often involve complicated and domain specific models (e.g. web services described by WSDL). In this paper, we explore a lightweight, middleware independent, model-driven development framework to help developers tame the challenges of composing IoT services that interoperate with one another. The framework is based upon two key contributions: i) patterns of interoperability behaviour, and ii) a software framework to monitor and reason about interoperability success or failure. We show using a case-study from the FI-WARE Future Internet Service domain that this interoperability framework can support non-expert developers address interoperability challenges. We also deployed tools built atop the framework and made them available in the XIFI large-scale FI-PPP test environment

Hyperfunctional complement C3 promotes C5-dependent atypical hemolytic uremic syndrome in mice

Atypical hemolytic uremic syndrome (aHUS) is frequently associated in humans with loss-of-function mutations in complement-regulating proteins or gain-of-function mutations in complement-activating proteins. Thus, aHUS provides an archetypal complement-mediated disease with which to model new therapeutic strategies and treatments. Herein, we show that, when transferred to mice, an aHUS-associated gain-of-function change (D1115N) to the complement-activation protein C3 results in aHUS. Homozygous C3 p.D1115N (C3KI) mice developed spontaneous chronic thrombotic microangiopathy together with hematuria, thrombocytopenia, elevated creatinine, and evidence of hemolysis. Mice with active disease had reduced plasma C3 with C3 fragment and C9 deposition within the kidney. Therapeutic blockade or genetic deletion of C5, a protein downstream of C3 in the complement cascade, protected homozygous C3KI mice from thrombotic microangiopathy and aHUS. Thus, our data provide in vivo modeling evidence that gain-of-function changes in complement C3 drive aHUS. They also show that long-term C5 deficiency is not accompanied by development of other renal complications (such as C3 glomerulopathy) despite sustained dysregulation of C3. Our results suggest that this preclinical model will allow testing of novel complement inhibitors with the aim of developing precisely targeted therapeutics that could have application in many complement-mediated diseases.</p

Sympathize for both

Rape is an ugly concept. Yet day after day I see articles in the Maine Campus of which the topic is none other than rape. I don\u27t mean to discount the importance of addressing such an issue, but why can\u27t we let the two involved in that unfortunate episode deal with the consequences by themselves