CHILDHOOD DEPRESSION: A DESCRIPTIVE STUDY ON A GROUP OF CHILDREN/STUDENTS IN PALERMO

An investigation was carried out on a group of students, 7-10 years old, aimed to evidence the presence of same of common symptoms of depression in childhood. Results reported demonstrated that more than 50% of the sample was often sad, nervous, anxious and suffers of sleeping disorders. The need was stressed of on early and correct diagnosis of infantile depression to sustain the child’s development and to give adequate treatment

Il cibo come farmaco: probiotici, prebiotici, simbiotici

Enteric microflora represent a protective barrier against infectious viruses, bacteria and toxins. Nutritional supplements constituted of live germs, producing and maintaining a condition of enteric eubioses may offer therapeutic possibilities against different pathologies

LGALS3BP antibody-drug-conjugate and its use for the treatment of cancer

The present invention relates to a special type of non-internalizing binding moiety- drug-conjugates that specifically target LGALS3BP. From one aspect, the invention relates to an antibody-drug-conjugate comprising an antibody capable of binding to LGALS3BP, said antibody being conjugated to cytotoxic drugs. The invention also comprises methods of the treatment of LGALS3BP-expressing cancer, including administering to a patient the disclosed drug conjugates and pharmaceutical preparations

Secreted Gal-3BP is a novel promising target for non-internalizing Antibody–Drug Conjugates

Abstract Galectin-3-binding protein (Gal-3BP) has been identified as a cancer and metastasis-associated, secreted protein that is expressed by the large majority of cancers. The present study describes a special type of non-internalizing antibody-drug-conjugates that specifically target Gal-3BP. Here, we show that the humanized 1959 antibody, which specifically recognizes secreted Gal-3BP, selectively localized around tumor but not normal cells. A site specific disulfide linkage with thiol-maytansinoids to unpaired cysteine residues of 1959, resulting in a drug-antibody ratio of 2, yielded an ADC product, which cured A375m melanoma bearing mice. ADC products based on the non-internalizing 1959 antibody may be useful for the treatment of several human malignancies, as the cognate antigen is abundantly expressed and secreted by several cancers, while being present at low levels in most normal adult tissues

PREVENZIONE REATTIVA, RIABILITAZIONE GLOBALE E FUNZIONE PEDAGOGICA

Rehabilitation should be considered as a global process which as from the medical treatment is aimed also to social integration at all levels of the disable individual. The purpose is directed to intervene not when somethin is not functioning but to act before in a way to establishing the conditions for a better quality of lyfe. Such conceptual change was determined in the first place by OMS statements which are not anymore referred to a disease to be removed but to the health which must be protected and promoted by means of educational interventions

Valutazione psicopedagogica e riabilitazione educativa negli ospedali pediatrici

The hospital recovery has a fandamental role concerning the diagnosis and the following treatment. The hospitalised child is subjected to a psychological trauma, linked to different factors, such as age, pathology, social and family context where he lives. He feels happy if the structure pays attention not only at his disease but also if it can satisfy all his needs

Pet therapy: therapeutic benefits of human-animal relation

In this work Authors analized the progressive increase and evoluated the benefits in the practical application of the Pet Therapy. Pet Therapy is a therapeutic aid, to add to not to substitute the traditional cares. Pet Therapy is intended not as an exclusive therapy but a support to medical cares and a possibility to enhance relational and emotional status of individuals as well as to give a contribution of wellbeing to the suffrance

STRESS AND CHILDHOOD

In this work the complexity of educational and rehabilitation interventions in different conditions of stress in childhood were underlined. The role played by educative agencies and different professionals, especially Educators, was indicated. The need for an integrated and coordinate intervention was stressed

Analysis of type of work and user in a neuromotorial rehabilitation unit

The activity in an operative neuromotorial rehabilitation unit was analyzed. An increasing attendance to the service was observed in the years 2001-2003. A new sensibility of the users and attention to a different approach in rehabilitation was indicated for obtaining this result. Recent legislation in administrative procedures to enter the services seems to have produced an increased request of rehabilitation activities