Sharing Cultural Heritage: the Clavius on the Web Project

In the last few years the amount of manuscripts digitized and made available on the Web has been constantly increasing. However, there is still a considarable lack of results concerning both the explicitation of their content and the tools developed to make it available. The objective of the Clavius on the Web project is to develop a Web platform exposing a selection of Christophorus Clavius letters along with three different levels of analysis: linguistic, lexical and semantic. The multilayered annotation of the corpus involves a XML-TEI encoding followed by a tokenization step where each token is univocally identified through a CTS urn notation and then associated to a part-of-speech and a lemma. The text is lexically and semantically annotated on the basis of a lexicon and a domain ontology, the former structuring the most relevant terms occurring in the text and the latter representing the domain entities of interest (e.g. people, places, etc.). Moreover, each entity is connected to linked and non linked resources, including DBpedia and VIAF. Finally, the results of the three layers of analysis are gathered and shown through interactive visualization and storytelling techniques. A demo version of the integrated architecture was developed

Chapter Rappresentazione, costruzione e visualizzazione di risorse terminologiche diacroniche nell’era del web semantico

This article introduces the model DIATERM, devoted to representing the diachronic evolution of concepts and terms in a given domain, according to Semantic Web standards and Linked Data technologies. The approach adopted for the representation of temporal information is based on the reification of N-ary relationships. DIATERM is articulated on three levels, textual, terminological and conceptual. Each level can be affected, more or less simultaneously, by change. The use of SWRL rules allows to automatically assign temporal information, thus facilitating the construction of the terminological resource and highlighting any inconsistencies. Two examples of interrogation and visualization of diachronic terminological resources will be illustrated. The first example is taken from the resource dedicated to the astronomical terminology introduced by Christopher Clavius in his Commentary on the Sacrobosco’s Tractatus de Sphaera. The second example is taken from the electronic lexicon of Ferdinand de Saussure's linguistic terminology

Precision tests of the Standard Model with leptonic and semileptonic kaon decays

We present a global analysis of leptonic and semileptonic kaon decays data, including all recent results by BNL-E865, KLOE, KTeV, ISTRA+, and NA48. Experimental results are critically reviewed and combined, taking into account theoretical (both analytical and numerical) constraints on the semileptonic kaon form factors. This analysis leads to a very accurate determination of Vus and allows us to perform several stringent tests of the Standard Model.We present a global analysis of leptonic and semileptonic kaon decays data, including all recent results by BNL-E865, KLOE, KTeV, ISTRA+, and NA48. Experimental results are critically reviewed and combined, taking into account theoretical (both analytical and numerical) constraints on the semileptonic kaon form factors. This analysis leads to a very accurate determination of Vus and allows us to perform several stringent tests of the Standard Model

Search for heavy neutral lepton production in K+ decays

A search for heavy neutral lepton production in K + decays using a data sample collected with a minimum bias trigger by the NA62 experiment at CERN in 2015 is reported. Upper limits at the 10−7 to 10−6 level are established on the elements of the extended neutrino mixing matrix |Ue4| 2 and |Uμ4| 2 for heavy neutral lepton mass in the ranges 170–448 MeV/c2 and 250–373 MeV/c2, respectively. This improves on the previous limits from HNL production searches over the whole mass range considered for |Ue4|2 and above 300 MeV/c2 for |Uμ4|2

Finding New Genes for Non-Syndromic Hearing Loss through an In Silico Prioritization Study

At present, 51 genes are already known to be responsible for Non-Syndromic hereditary Hearing Loss (NSHL), but the knowledge of 121 NSHL-linked chromosomal regions brings to the hypothesis that a number of disease genes have still to be uncovered. To help scientists to find new NSHL genes, we built a gene-scoring system, integrating Gene Ontology, NCBI Gene and Map Viewer databases, which prioritizes the candidate genes according to their probability to cause NSHL. We defined a set of candidates and measured their functional similarity with respect to the disease gene set, computing a score () that relies on the assumption that functionally related genes might contribute to the same (disease) phenotype. A Kolmogorov-Smirnov test, comparing the pair-wise distribution on the disease gene set with the distribution on the remaining human genes, provided a statistical assessment of this assumption. We found at a p-value that the former pair-wise is greater than the latter, justifying a prioritization strategy based on the functional similarity of candidate genes respect to the disease gene set. A cross-validation test measured to what extent the ranking for NSHL is different from a random ordering: adding 15% of the disease genes to the candidate gene set, the ranking of the disease genes in the first eight positions resulted statistically different from a hypergeometric distribution with a p-value and a power. The twenty top-scored genes were finally examined to evaluate their possible involvement in NSHL. We found that half of them are known to be expressed in human inner ear or cochlea and are mainly involved in remodeling and organization of actin formation and maintenance of the cilia and the endocochlear potential. These findings strongly indicate that our metric was able to suggest excellent NSHL candidates to be screened in patients and controls for causative mutations

Measurement of the very rare K+→π+ννˉK^+ \to \pi^+ \nu \bar\nu decay

The decay K+→π+νν¯ , with a very precisely predicted branching ratio of less than 10−10 , is among the best processes to reveal indirect effects of new physics. The NA62 experiment at CERN SPS is designed to study the K+→π+νν¯ decay and to measure its branching ratio using a decay-in-flight technique. NA62 took data in 2016, 2017 and 2018, reaching the sensitivity of the Standard Model for the K+→π+νν¯ decay by the analysis of the 2016 and 2017 data, and providing the most precise measurement of the branching ratio to date by the analysis of the 2018 data. This measurement is also used to set limits on BR(K+→π+X ), where X is a scalar or pseudo-scalar particle. The final result of the BR(K+→π+νν¯ ) measurement and its interpretation in terms of the K+→π+X decay from the analysis of the full 2016-2018 data set is presented, and future plans and prospects are reviewed

Chapter Rappresentazione, costruzione e visualizzazione di risorse terminologiche diacroniche nell’era del web semantico

This article introduces the model DIATERM, devoted to representing the diachronic evolution of concepts and terms in a given domain, according to Semantic Web standards and Linked Data technologies. The approach adopted for the representation of temporal information is based on the reification of N-ary relationships. DIATERM is articulated on three levels, textual, terminological and conceptual. Each level can be affected, more or less simultaneously, by change. The use of SWRL rules allows to automatically assign temporal information, thus facilitating the construction of the terminological resource and highlighting any inconsistencies. Two examples of interrogation and visualization of diachronic terminological resources will be illustrated. The first example is taken from the resource dedicated to the astronomical terminology introduced by Christopher Clavius in his Commentary on the Sacrobosco’s Tractatus de Sphaera. The second example is taken from the electronic lexicon of Ferdinand de Saussure's linguistic terminology

Text Encoder and Annotator: an all-in-one editor for transcribing and annotating manuscripts with RDF

Abstract. In the context of the digitization of manuscripts, transcription and annotation are often distinct, sequential steps. This could lead to diculties in improving the transcribed text when annotations have already been dened. In order to avoid this, we devised an approach which merges the two steps into the same process. Text Encoder and Annotator (TEA) is a prototype application embracing this concept. TEA is based on a lightweight language syntax which annotates text using Semantic Web technologies. Our approach is currently being developed within the Clavius on the Web project, devoted to studying the manuscripts of Christophorus Clavius, an inuential 16th century mathematician and astronomer