A Multi-path Interferometer with Ultracold Atoms Trapped in an Optical Lattice

We study an ultra-cold gas of $N$ bosons trapped in a one dimensional $M$-site optical lattice perturbed by a spatially dependent potential $g\cdot x^j$, where the unknown coupling strength $g$ is to be estimated. We find that the measurement uncertainty is bounded by $\Delta g\propto\frac1{N (M^j-1)}$. For a typical case of a linear potential, the sensitivity improves as $M^{-1}$, which is a result of multiple interferences between the sites -- an advantage of multi-path interferometers over the two-mode setups. Next, we calculate the estimation sensitivity for a specific measurement where, after the action of the potential, the particles are released from the lattice and form an interference pattern. If the parameter is estimated by a least-square fit of the average density to the interference pattern, the sensitivity still scales like $M^{-1}$ for linear potentials and can be further improved by preparing a properly correlated initial state in the lattice.Comment: 11 pages, 3 fugire

Discrete Breathers in a Realistic Coarse-Grained Model of Proteins

We report the results of molecular dynamics simulations of an off-lattice protein model featuring a physical force-field and amino-acid sequence. We show that localized modes of nonlinear origin (discrete breathers) emerge naturally as continuations of a subset of high-frequency normal modes residing at specific sites dictated by the native fold. In the case of the small $\beta$-barrel structure that we consider, localization occurs on the turns connecting the strands. At high energies, discrete breathers stabilize the structure by concentrating energy on few sites, while their collapse marks the onset of large-amplitude fluctuations of the protein. Furthermore, we show how breathers develop as energy-accumulating centres following perturbations even at distant locations, thus mediating efficient and irreversible energy transfers. Remarkably, due to the presence of angular potentials, the breather induces a local static distortion of the native fold. Altogether, the combination of this two nonlinear effects may provide a ready means for remotely controlling local conformational changes in proteins.Comment: Submitted to Physical Biolog

Behaviour of traditional Portuguese timber roof structures

The aim of this paper is to present the results of a structural analysis of common trusses traditionally used in roof construction in Portugal. The study includes the results of a preliminary survey intending to assess the geometry, materials and on site pathologies, as well as a twodimensional linear elastic static and dynamic analysis. The trusses behaviour under symmetric and non-symmetric loads, the king post/tie-beam connection, the stiffness of the joints and the incorrect positioning of the purlins, were some of the structural aspects that have been investigated

Experimental analysis of original and strengthened traditional timber connections

Tests on full-scale unstrengthened connections were performed under monotonic and cyclic loading. Attention has been principally focused on the birdsmouth joint, because of its common use in practice. Different strengthening solutions with metal elements have been evaluated

Modelling of timber joints in traditional structures

Original unstrengthened timber connections and the effects of different strengthening techniques have been evaluated experimentally with tests on full-scale birdsmouth joints. Experimental results show that structural response of traditional timber connections under cyclic loading cannot be represented by common constraint models, like perfect hinges or rigid joints, but should be using semi-rigid and friction based models. A research program has investigated the behaviour of old timber joints and examined strengthening criteria. The main parameters affecting the mechanical behaviour of the connection have been singled out. A synthetic model of cyclic behaviour has been adapted on the basis of experimental results

Enhancing interferometric sensitivity by non-classical light from quantum non-demolition measurements in cavity QED

We propose an enhanced optical interferometer based on tailored non-classical light generated by nonlinear dynamics and projective measurements in a three-level atom cavity QED system. A coherent state in the cavity becomes dynamically entangled with two ground states of the atom and is transformed to a macroscopic superposition state via a projective measurement on the atom. We show that the resulting highly non-classical state can improve interferometric precision measurements well beyond the shot-noise limit once combined with a classical laser pulse at the input of a Mach-Zehnder interferometer. For a practical implementation, we identify an efficient phase shift estimation scheme based on the counting of photons at the interferometer output. Photon losses and photon-counting errors deteriorate the interferometer sensitivity, but we demonstrate that it still can be significantly better than the shot-noise limit under realistic conditions.Comment: 9 pages, 10 figure

The IR-Completion of Gravity: What happens at Hubble Scales?

We have recently proposed an "Ultra-Strong" version of the Equivalence Principle (EP) that is not satisfied by standard semiclassical gravity. In the theory that we are conjecturing, the vacuum expectation value of the (bare) energy momentum tensor is exactly the same as in flat space: quartically divergent with the cut-off and with no spacetime dependent (subleading) ter ms. The presence of such terms seems in fact related to some known difficulties, such as the black hole information loss and the cosmological constant problem. Since the terms that we want to get rid of are subleading in the high-momentum expansion, we attempt to explore the conjectured theory by "IR-completing" GR. We consider a scalar field in a flat FRW Universe and isolate the first IR-correction to its Fourier modes operators that kills the quadratic (next to leading) time dependent divergence of the stress energy tensor VEV. Analogously to other modifications of field operators that have been proposed in the literature (typically in the UV), the present approach seems to suggest a breakdown (here, in the IR, at large distances) of the metric manifold description. We show that corrections to GR are in fact very tiny, become effective at distances comparable to the inverse curvature and do not contain any adjustable parameter. Finally, we derive some cosmological implications. By studying the consistency of the canonical commutation relations, we infer a correction to the distance between two comoving observers, which grows as the scale factor only when small compared to the Hubble length, but gets relevant corrections otherwise. The corrections to cosmological distance measures are also calculable and, for a spatially flat matter dominated Universe, go in the direction of an effective positive acceleration.Comment: 27 pages, 2 figures. Final version, references adde

Energy transfer in nonlinear network models of proteins

We investigate how nonlinearity and topological disorder affect the energy relaxation of local kicks in coarse-grained network models of proteins. We find that nonlinearity promotes long-range, coherent transfer of substantial energy to specific, functional sites, while depressing transfer to generic locations. Remarkably, transfer can be mediated by the self-localization of discrete breathers at distant locations from the kick, acting as efficient energy-accumulating centers.Comment: 4 pages, 3 figure

New insight into cataract formation -- enhanced stability through mutual attraction

Small-angle neutron scattering experiments and molecular dynamics simulations combined with an application of concepts from soft matter physics to complex protein mixtures provide new insight into the stability of eye lens protein mixtures. Exploring this colloid-protein analogy we demonstrate that weak attractions between unlike proteins help to maintain lens transparency in an extremely sensitive and non-monotonic manner. These results not only represent an important step towards a better understanding of protein condensation diseases such as cataract formation, but provide general guidelines for tuning the stability of colloid mixtures, a topic relevant for soft matter physics and industrial applications.Comment: 4 pages, 4 figures. Accepted for publication on Phys. Rev. Let

Muscle-driven forward dynamic simulations for the study of normal and pathological gait

There has been much recent interest in the use of muscle-actuated forward dynamic simulations to describe human locomotion. These models simulate movement through the integration of dynamic equations of motion and usually are driven by excitation inputs to muscles. Because motion is effected by individual muscle actuators, these simulations offer potential insights into the roles played by muscles in producing walking motions. Better knowledge of the actions of muscles should lead to clarification of the etiology of movement disorders and more effective treatments. This article reviews the use of such simulations to characterize musculoskeletal function and describe the actions of muscles during normal and pathological locomotion. The review concludes by identifying ways in which models must be improved if their potential for clinical utility is to be realized