Reasoning and Social Context: the Role of Social Status and Power

Recent work linking feminist epistemology with social epistemology draws attention to the role of status and power in understanding knowledge and reasoning in social context. I argue that considerations of social justice require better understandings of two particular components of reasoning and social context: (i) abstraction—who gets to abstract, how, and why? (ii) the individual-social distinction—how do particular understandings of this distinction serve to minimize or elucidate the role of status and power

Commentary on: Kathryn J. Norlock\u27s Receptivity as a virtue of (practitioners of) argumentation

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The First Nakba Novel? on Standing with Palestine

I wish to take this opportunity to respond to Bart Moore-Gilbert's essay “Palestine, Postcolonialism and Pessoptimism” by suggesting how its concerns might be amplified through a consideration of Ethel Mannin's nakba novel The Road to Beersheba (1963b). I offer my reading of Mannin's novel in the spirit of an unfinished dialogue with Bart Moore-Gilbert's work and as a tribute to his commitment to justice

Comparison of Human Memory CD8 T Cell Responses to Adenoviral Early and Late Proteins in Peripheral Blood and Lymphoid Tissue

Treatment of invasive adenovirus (Ad) disease in hematopoietic stem cell transplant (SCT) recipients with capsid protein hexon-specific donor T cells is under investigation. We propose that cytotoxic T cells (CTLs) targeted to the late protein hexon may be inefficient in vivo because the early Ad protein E3-19K downregulates HLA class I antigens in infected cells. In this study, CD8+ T cells targeted to highly conserved HLA A2-restricted epitopes from the early regulatory protein DNA polymerase (P-977) and late protein hexon (H-892) were compared in peripheral blood (PB) and tonsils of naturally infected adults. In tonsils, epitope-specific pentamers detected a significantly higher frequency of P-977+CD8+ T cells compared to H-892+CD8+ T cells; this trend was reversed in PB. Tonsil epitope-specific CD8+ T cells expressed IFN-γ and IL-2 but not perforin or TNF-α, whereas PB T cells were positive for IFN-γ, TNF-α, and perforin. Tonsil epitope-specific T cells expressed lymphoid homing marker CCR7 and exhibited lower levels of the activation marker CD25 but higher proliferative potential than PB T cells. Finally, in parallel with the kinetics of mRNA expression, P-977-specific CTLs lysed targets as early as 8 hrs post infection. In contrast, H-892-specific CTLs did not kill unless infected fibroblasts were pretreated with IFN-γ to up regulate HLA class I antigens, and cytotoxicity was delayed until 16–24 hours. These data show that, in contrast to hexon CTLs, central memory type DNA polymerase CTLs dominate the lymphoid compartment and kill fibroblasts earlier after infection without requiring exogenous IFN-γ. Thus, use of CTLs targeted to both early and late Ad proteins may improve the efficacy of immunotherapy for life-threatening Ad disease in SCT recipients

Philosophy, Adversarial Argumentation, and Embattled Reason

Philosophy’s adversarial argumentation style is often noted as a factor contributing to the low numbers of women in philosophy. I argue that there is a level of adversariality peculiar to philosophy that merits specific feminist examination, yet doesn’t assume controversial gender differences claims. The dominance of the argument-as-war metaphor is not warranted, since this metaphor misconstrues the epistemic role of good argument as a tool of rational persuasion. This metaphor is entangled with the persisting narrative of embattled reason, which, in turn, is linked to the sexism-informed narrative of the “man of reason” continually warding off or battling “feminine” unreason

Introduction: Reasoning for Change

This special issue of Informal Logic brings together two important areas of philosophy that have shown significant development in the last three decades: informal logic and feminist philosophy. A significant innovation they both share is new thinking about practices of argumentation and related practices of reasoning. Feminist theorizing supporting social and political change foregrounds “reasoning for change” in a way that draws attention to the contextual and rhetorical dimensions of argument and thus connects with significant developments in informal logic.