ANTI-RADICAL ACTIVITIES OF XANTHONES AND FLAVONOIDS FROM GARCINIA SCHOMBURGKIANA

Objective: The present study aimed to isolate and identify the phytochemical constituents of Garcinia schomburgkiana branches and evaluate the antioxidant activity of the compounds.Methods: The chromatographic and spectroscopic (UV, IR, NMR and MS) techniques were used for the isolation and elucidation of the compounds, respectively. The antioxidant activity of the isolated compounds was examined through DPPH, ABTS, nitric oxide and hydroxyl radical scavenging assay.Results: The (-)-5,7,3′,5′-tetrahydroxyflavanone (1), which was firstly found in the Garcinia species, together with kaempferol (2), (-)-dihydrokaempferol (3), euxanthone (4), gentisein (5) and norathyriol (6) were isolated from G. schomburgkiana. Among the isolated compounds, compound 1 and 6 exhibited the highest potential for anti-radical activities.Conclusion: Compound 1 could be used as the chemotaxonomic marker of G. schomburgkiana. The branches of G. schomburgkiana could be the alternative source of the antioxidants. The possible inhibitory mechanisms were proposed through the action of electron transfer, chelation, and nitrosylation.Â

Trichodermaerin: a diterpene lactone from Trichoderma asperellum

The title compound, C20H28O3, known as `trichodermaerin' [systematic name: (4E)-4,9,15,16,16-pentamethyl-6-oxatetracyclo[10.3.1.01,10.05,9]hexadec-4-ene-7,13-dione], is a diterpene lactone which was isolated from Trichoderma asperellum. The structure has a tetracycic 6–5–7–5 ring system, with the cyclohexanone ring adopting a twisted half-chair conformation and the cyclopentane ring adopting a half-chair conformation, whereas the cycloheptene and tetrahydrofurananone rings are in chair and envelope (with the methyl-substituted C atom as the flap) conformations, respectively. The three-dimensional architecture is stabilized by C—H...O interactions

Trichoharzianol, a New Antifungal from Trichoderma harzianum F031

A new decalin derivative, trichoharzianol (<b>1</b>), together with three known compounds, eujavanicol A (<b>2</b>), 5-hydroxy-3-hydroxymethyl-2-methyl-7-methoxychromone (<b>3</b>), and 4,6-dihydroxy-5-methylphthalide (<b>4</b>), were isolated from Trichoderma harzianum F031. For the first time, compounds <b>2</b>–<b>4</b> were reported from the Trichoderma species. Their structures were characterized by spectroscopic methods. Trichoharzianol (<b>1</b>) showed the highest antifungal activity against Colletotrichum gloeosporioides, with a minimum inhibitory concentration (MIC) of 128 μg/mL