Supersymmetry Without Prejudice at the LHC

The discovery and exploration of Supersymmetry in a model-independent fashion will be a daunting task due to the large number of soft-breaking parameters in the MSSM. In this paper, we explore the capability of the ATLAS detector at the LHC ($\sqrt s=14$ TeV, 1 fb$^{-1}$) to find SUSY within the 19-dimensional pMSSM subspace of the MSSM using their standard transverse missing energy and long-lived particle searches that were essentially designed for mSUGRA. To this end, we employ a set of $\sim 71$k previously generated model points in the 19-dimensional parameter space that satisfy all of the existing experimental and theoretical constraints. Employing ATLAS-generated SM backgrounds and following their approach in each of 11 missing energy analyses as closely as possible, we explore all of these $71$k model points for a possible SUSY signal. To test our analysis procedure, we first verify that we faithfully reproduce the published ATLAS results for the signal distributions for their benchmark mSUGRA model points. We then show that, requiring all sparticle masses to lie below 1(3) TeV, almost all(two-thirds) of the pMSSM model points are discovered with a significance $S>5$ in at least one of these 11 analyses assuming a 50\% systematic error on the SM background. If this systematic error can be reduced to only 20\% then this parameter space coverage is increased. These results are indicative that the ATLAS SUSY search strategy is robust under a broad class of Supersymmetric models. We then explore in detail the properties of the kinematically accessible model points which remain unobservable by these search analyses in order to ascertain problematic cases which may arise in general SUSY searches.Comment: 69 pages, 40 figures, Discussion adde

Pneumonia: Drug-Related Problems and Hospital Readmissions

Pneumonia is one of the most common infectious diseases and the fourth leading cause of death globally. According to US statistics in 2019, pneumonia is the most common cause of sepsis and septic shock. In the US, inpatient pneumonia hospitalizations account for the top 10 highest medical costs, totaling $9.5 billion for 960,000 hospital stays. The emergence of antibiotic resistance in the treatment of infectious diseases, including the treatment of pneumonia, is a globally alarming problem. Antibiotic resistance increases the risk of death and re-hospitalization, prolongs hospital stays, and increases treatment costs, and is one of the greatest threats in modern medicine. Drug-related problems (DRPs) in pneumonia - such as suboptimal antibiotic indications, prolonged treatment duration, and drug interactions - increase the rate of antibiotic resistance and adverse effects, thereby leading to an increased burden in treatment. In a context in which novel and effective antibiotics are scarce, mitigating DRPs in order to reduce antibiotic resistance is currently a prime concern. A variety of interventions proven useful in reducing DRPs are antibiotic stewardship programs, the use of biomarkers, computerized physician order entries and clinical decision support systems, and community-acquired pneumonia scores

Virus diseases risk-factors associated with shrimp farming practices in rice-shrimp and intensive culture systems in Mekong Delta Viet Nam

In Mekong Delta, viral infection, including white spot syndrome virus (WSSV), monodon baculovirus (MBV), heptopancreatic parvovirus (HPV), infectious hypodermal and hematopoietic necrosis virus (IHHNV) and gill-associated nidovirus (GAV) frequently infect cultured shrimp starting at the postlarvae stage. These viral infections cause high mortality of shrimp and affect the farmer’s income. Previous studies mainly focused on the detection, transmission and genetic variation of the pathogens, but few studied the correlation between disease occurrence and other factors, including pond conditions, culture technique and management. Three studies analysed the association of culture factors with the WSSV disease incidence determining risk and potential protective factors in freshwater rice-shrimp systems, and brackish water polyculture and monoculture of black tiger shrimp (Penaeus monodon). Studies on the risk and protective factors in the odd of viral diseases in rice-shrimp rotation were lacking, while in 2011 the Early Mortality Syndrome (EMS)/Acute Hepatopancreatic Necrosis Syndrome (AHPNS) caused the great losses of cultured shrimp in Mekong Delta. This study was carried out to describe the culture status of shrimp in Mekong Delta and to identify the risk and/or protective factors that related to disease incidences in black tiger shrimp cultured in 2011. Through interviews, 58 variables collected from 191 farmers (64: rice-shrimp rotation and 127: intensive system) in Soc Trang and Bac Lieu Provinces, Viet Nam. The data were analysed in two steps of variable reduction to increase model stability and binary logistic regression to identify the risk and/or protective factors. The results showed that the risk factors were pond size (entire dataset, rice-shrimp rotation and intensive culture), settling pond (entire dataset), period of pond dry (entire dataset), stocking density first (rice-shrimp rotation), and stocking density second (rice-shrimp rotation). The potential protective factors were the mode of water intake (entire dataset), water level (entire dataset and rice-shrimp rotation), water quality parameters before stocking (entire dataset), and fry test (rice-shrimp rotation)

Human Brucella melitensis infections in southern Vietnam

Brucellosis is a collective term for infections caused by small Gram-negative coccobacilli belonging to genus Brucella. This genus incorporates the well-described animal pathogens Brucella melitensis, Brucella abortus, Brucella ovis, Brucella suis, and Brucella canis, which are associated with disease in goats, cattle, sheep, pigs, and dogs, respectively. Brucella are facultative intracellular pathogens, and are sequestered by monocytes and macrophages, spreading throughout the body to the liver, spleen, lymph nodes, and bone marrow [1]. These pathogens are synonymous with an aggressive disease syndrome in animals causing abortion, stillbirth, and the delivery of weak offspring. The organisms replicate to high concentrations in the affected tissues and are transmitted through contact with the placenta, foetus, foetal fluids, and vaginal discharge. Notably, goats can shed B. melitensis in vaginal discharge for up to 3 months after abortion and organisms can be shed in milk for the lifetime of an infected animalLa brucelosis es un término colectivo para las infecciones causadas por pequeños coccobacilos Gram-negativos pertenecientes al género Brucella. Este género incorpora los patógenos animales bien descritos Brucella melitensis, Brucella abortus, Brucella ovis, Brucella suis y Brucella canis, que se asocian con enfermedades en cabras, vacas, ovejas, cerdos y perros, respectivamente. Las Brucella son patógenos intracelulares facultativos, y son secuestrados por monocitos y macrófagos, extendiéndose por todo el cuerpo hasta el hígado, el bazo, los ganglios linfáticos y la médula ósea [1]. Estos patógenos son sinónimos de un síndrome de enfermedad agresiva en los animales que causa aborto, mortinato y el nacimiento de una descendencia débil. Los organismos se replican en altas concentraciones en los tejidos afectados y se transmiten a través del contacto con la placenta, el feto, los fluidos fetales y el flujo vaginal. Notablemente, las cabras pueden derramar B. melitensis en el flujo vaginal hasta 3 meses después del aborto y los organismos pueden ser derramados en la leche durante toda la vida de un animal infectado.Universidad Nacional, Costa RicaEscuela de Medicina Veterinari

Human Brucella melitensis infections in southern Vietnam

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On the inclusion of dissipation on top of mean-field approaches

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