Performance comparison of abrasion resistant textile motorcycle clothing

 Falling at speed onto a tarmac surface during cycling can cause abrasion and laceration of the skin and body tissue. Motorcycle clothing designed to reduce or avoid this type of injury has traditionally been made of animal leather as it has well known resistance to abrasion. In the last 20 years there has been an emergence of textile clothing reinforced with high performance/tenacity fibres such as those made from polyamides, aramids, ultra high molecular weight polyethylene and liquid crystal. Almost no comparative work has been undertaken to provide insight into the level of protection these clothing layers can provide.This work has used a CE standard test method to evaluate a number of abrasion resistant textile pant products and compare them with a leather race product. It analysed the protective fabric layer structure for mass, thickness, construction method and resistance to abrasion.Structures manufactured from high tenacity fibres performed better than those from lower tenacity ones. Fabric construction method and mass per unit area were the two key variables in providing an abrasion protective layer. Structures manufactured from knitted para-aramid fibres performed better than their woven counterparts due to the method of fabric failure. Several well designed protective layers performed at a similar level to that of leather; however, most garments tested failed to meet the lower level European standard of abrasion resistance (CE level 1), which may put their wearer at risk in the advent of a collision

Role of the mesoamygdaloid dopamine projection in emotional learning

Amygdala dopamine is crucially involved in the acquisition of Pavlovian associations, as measured via conditioned approach to the location of the unconditioned stimulus (US). However, learning begins before skeletomotor output, so this study assessed whether amygdala dopamine is also involved in earlier 'emotional' learning. A variant of the conditioned reinforcement (CR) procedure was validated where training was restricted to curtail the development of selective conditioned approach to the US location, and effects of amygdala dopamine manipulations before training or later CR testing assessed. Experiment 1a presented a light paired (CS+ group) or unpaired (CS- group) with a US. There were 1, 2 or 10 sessions, 4 trials per session. Then, the US was removed, and two novel levers presented. One lever (CR+) presented the light, and lever pressing was recorded. Experiment 1b also included a tone stimulus. Experiment 2 applied intra-amygdala R(+) 7-OH-DPAT (10 nmol/1.0 A mu l/side) before two training sessions (Experiment 2a) or a CR session (Experiment 2b). For Experiments 1a and 1b, the CS+ group preferred the CR+ lever across all sessions. Conditioned alcove approach during 1 or 2 training sessions or associated CR tests was low and nonspecific. In Experiment 2a, R(+) 7-OH-DPAT before training greatly diminished lever pressing during a subsequent CR test, preferentially on the CR+ lever. For Experiment 2b, R(+) 7-OH-DPAT infusions before the CR test also reduced lever pressing. Manipulations of amygdala dopamine impact the earliest stage of learning in which emotional reactions may be most prevalent

Left High and Dry: Deglaciation of Dogger Bank, North Sea, Recorded in Proglacial Lake Evolution

Reconstructions of palaeo-ice sheet retreat in response to climate warming using offshore archives can provide vital analogs for future ice-sheet behavior. At the Last Glacial Maximum, Dogger Bank, in the southern North Sea, was covered by the Eurasian Ice Sheet. However, the maximum extent and behavior of the ice sheet in the North Sea basin is poorly constrained. We reveal ice-marginal dynamics and maximum ice extent at Dogger Bank through sedimentological and stratigraphic investigation of glacial and proglacial lake sediments. We use a large, integrated subsurface dataset of shallow seismic reflection and geotechnical data collected during windfarm site investigation. For the first time, an ice stream is identified at Dogger Bank, based on preserved subglacial bedforms, eskers and meltwater channels. During ice-sheet advance, a terminal thrust-block moraine complex formed, whose crest runs approximately north-northeast to south-southwest. Subsequent ice stream shutdown caused stagnation of ice, and rapid retreat of the ice-sheet margin. The moraine complex, and outwash head from an adjacent ice-sheet lobe to the west, dammed a large (approximately 750 km2) proglacial lake. Subsequent sedimentation infilled the lake with 30 m of glacial outwash sediments. A lobate subaqueous fan formed at the ice-sheet margin, which thins toward the southeast with iceberg scours and ice-rafted debris at the base, and is onlapped by lake sediments calibrated to core as alternating clay and silt laminae, interpreted to be varves. The lake became isolated from the retreating ice-sheet margin, and ice-sheet retreat slowed. Sediment-laden meltwater was supplied to the ice-distal proglacial lake for c. 1500–2000 years. Subsequent ice-sheet retreat off Dogger Bank was more rapid due to the negative subglacial slope. The stepped retreat of rapid downwasting, slow retreat, and a final rapid phase off Dogger Bank occurred after the LGM at around 27 ka and before formation of a ribbon lake, dated previously to 23 ka and approximately 60 m lower in elevation, formed to the north of Dogger Bank. The complicated stratigraphic architecture revealed through these data improves forecasting of ground conditions for turbine footings at Dogger Bank, an important step in the provision of clean, sustainable energy

Misincorporation Proteomics Technologies: A Review.

Proteinopathies are diseases caused by factors that affect proteoform conformation. As such, a prevalent hypothesis is that the misincorporation of noncanonical amino acids into a proteoform results in detrimental structures. However, this hypothesis is missing proteomic evidence, specifically the detection of a noncanonical amino acid in a peptide sequence. This review aims to outline the current state of technology that can be used to investigate mistranslations and misincorporations whilst framing the pursuit as Misincorporation Proteomics (MiP). The current availability of technologies explored herein is mass spectrometry, sample enrichment/preparation, data analysis techniques, and the hyphenation of approaches. While many of these technologies show potential, our review reveals a need for further development and refinement of approaches is still required

Correction: Steele et al. Misincorporation Proteomics Technologies: A Review. Proteomes 2021, 9, 2.

In the original publication, there was a mistake in Table 2 as published [...]

Early virological response to HIV treatment: can we predict who is likely to experience subsequent treatment failure? Results from an observational cohort study, London, UK

INTRODUCTION: For people living with HIV, the first antiretroviral treatment (ART) regimen offers the best chance for a good virological response. Early identification of those unlikely to respond to first‐line ART could enable timely intervention and increase chances of a good initial treatment response. In this study we assess the extent to which the HIV RNA viral load (VL) at 1 and 3 months is predictive of first‐line treatment outcome at 6 months. METHODS: All previously ART‐naive individuals starting ART at two London centres since 2000 with baseline (−180 to 3 days) VL >500 c/mL had a VL measurement between 6 and 12 months after starting ART, and at least one at month 1 (4–60 days) or month 3 (61–120 days) were included. Lack of treatment response was defined as (i) VL >200 copies/mL at 6 months or (ii) VL >200 copies/mL at 6 months or simultaneous switch in drugs from at least two different drug classes before 6 months. The association with VL measurements at 1 and 3 months post‐ART; change from pre‐ART in these values; and CD4 count measurements at 1 and 3 months were assessed using logistic regression models. The relative fit of the models was compared using the Akaike information criterion (AIC). RESULTS: A total of 198 out of 3258 individuals (6%) experienced lack of treatment response at 6 months (definition i), increasing to 511 (16%) for definition (ii). Those with a 1‐month (day 4–60 window) VL of 100,000 copies/ml had a 4%, 8%, 23% and 24% chance, respectively, of subsequently experiencing treatment non‐response at 6 months (definition (i)). When considering the 3‐month (day 61–120 window) VL, the chances of subsequently experiencing treatment non‐response were, respectively, 3%, 25%, 67% and 75%. Results were similar for definition (ii). CONCLUSIONS: Whilst 3‐month VL provides good discrimination between low and high risk of treatment failure, 1‐month VL does not. Presence of a VL >10,000 copies/ml after 3 months of ART is a cutoff above which individuals are at a sufficiently higher risk of non‐response that they may be considered for intervention

Conditionality in context: Incapacity benefit and social deprivation in Merthyr Tydfil

2.1 The welfare contract..........................................................................

All-cause hospitalisation according to demographic group in people living with HIV in the current ART era: Recent findings from a cohort study in the UK

OBJECTIVE: We investigated differences in all-cause hospitalisation between key demographic groups among people with HIV in the UK in the current ART era. DESIGN/METHODS: We used data from the Royal Free HIV Cohort study between 2007 and 2018. Individuals were classified into five groups: men who have sex with men (MSM), Black African men who have sex with women (MSW), MSW of other ethnicity, Black African women and women of other ethnicity. We studied hospitalisations during the first year after HIV diagnosis (Analysis-A) separately from those more than one year after diagnosis (Analysis-B). In Analysis-A, time to first hospitalisation was assessed using Cox regression adjusted for age and diagnosis date. In Analysis-B, subsequent hospitalisation rate was assessed using Poisson regression, accounting for repeated hospitalisation within individuals, adjusted for age, calendar year, time since diagnosis. RESULTS: The hospitalisation rate was 30.7/100 person-years in the first year after diagnosis and 2.7/100 person-years subsequently; 52% and 13% hospitalisations respectively were AIDS-related. Compared to MSM, MSW and women were at much higher risk of hospitalisation during the first year [aHR (95%CI): 2.7 (1.7-4.3), 3.0 (2.0-4.4), 2.0 (1.3-2.9), 3.0 (2.0-4.5) for Black African MSW; other ethnicity MSW; Black African women; other ethnicity women respectively, Analysis-A] and remained at increased risk subsequently [corresponding aIRR (95% CI): 1.7 (1.2-2.4), 2.1 (1.5-2.8), 1.5 (1.1-1.9), 1.7 (1.2-2.3), Analysis-B]. CONCLUSIONS: In this setting with universal healthcare, substantial variation exists in hospitalisation risk across demographic groups, both in early and subsequent periods after HIV diagnosis, highlighting the need for targeted interventions