Auditory Attention and Comprehension During a Simulated Night Shift: Effects of Task Characteristics

OBJECTIVE: The current study investigated performance on a dual auditory task during a simulated night shift. BACKGROUND: Night shifts and sleep deprivation negatively affect performance on vigilance-based tasks, but less is known about the effects on complex tasks. Because language processing is necessary for successful work performance, it is important to understand how it is affected by night work and sleep deprivation. METHOD: Sixty-two participants completed a simulated night shift resulting in 28 hr of total sleep deprivation. Performance on a vigilance task and a dual auditory language task was examined across four testing sessions. RESULTS: The results indicate that working at night negatively impacts vigilance, auditory attention, and comprehension. The effects on the auditory task varied based on the content of the auditory material. When the material was interesting and easy, the participants performed better. Night work had a greater negative effect when the auditory material was less interesting and more difficult. CONCLUSION: These findings support research that vigilance decreases during the night. The results suggest that auditory comprehension suffers when individuals are required to work at night. Maintaining attention and controlling effort especially on passages that are less interesting or more difficult could improve performance during night shifts. APPLICATION: The results from the current study apply to many work environments where decision making is necessary in response to complex auditory information. Better predicting the effects of night work on language processing is important for developing improved means of coping with shiftwork

Predictors of Driving in Individuals with Relapsing–Remitting Multiple Sclerosis

Evaluations on fitness-to-drive of individuals with multiple sclerosis (MS) usually involve the administration of several physical, visual, and cognitive tests. In some instances, a practical road test is also administered. The use of several tests, many of which are only remotely driving-related, increases the time, cost, and human resources involved in the evaluation process, and sometimes lead to erroneous decisions. In this study, we investigated the usefulness of using a short battery of a few highly predictive tests to predict fitness-to-drive of individuals with MS. Fortyfour individuals with relapsing–remitting MS (age = 46 ± 11 years, 37 females) and Expanded Disability Status Scale values between 1 and 7 were administered selected physical, visual and cognitive tests including the Stroke Driver Screening Assessment (SDSA) battery. Performance on 12 cognitive and three visual tests were significantly associated with participants’ performance on a practical road test. The Stroop Color test, Direction, Compass, and Road Sign Recognition tests from the SDSA, and the Speed of Processing test from Useful Field of View test battery together explained 59% of the variance and predicted the pass or fail outcome on the road test with 91% accuracy, 70% sensitivity, and 97% specificity. The five psychometric/off-road tests, which together can be administered in less than 45 minutes, cost approximately $150, and is 91% accurate, can be used as a screening battery. Those who pass should be further tested on-road to finally decide their fitness-to-drive while those of fail should be further evaluated, trained, or advised on alternative transportation means. Future studies are needed to confirm and validate the findings in this study

Prions Adhere to Soil Minerals and Remain Infectious

An unidentified environmental reservoir of infectivity contributes to the natural transmission of prion diseases (transmissible spongiform encephalopathies [TSEs]) in sheep, deer, and elk. Prion infectivity may enter soil environments via shedding from diseased animals and decomposition of infected carcasses. Burial of TSE-infected cattle, sheep, and deer as a means of disposal has resulted in unintentional introduction of prions into subsurface environments. We examined the potential for soil to serve as a TSE reservoir by studying the interaction of the disease-associated prion protein (PrP(Sc)) with common soil minerals. In this study, we demonstrated substantial PrP(Sc) adsorption to two clay minerals, quartz, and four whole soil samples. We quantified the PrP(Sc)-binding capacities of each mineral. Furthermore, we observed that PrP(Sc) desorbed from montmorillonite clay was cleaved at an N-terminal site and the interaction between PrP(Sc) and Mte was strong, making desorption of the protein difficult. Despite cleavage and avid binding, PrP(Sc) bound to Mte remained infectious. Results from our study suggest that PrP(Sc) released into soil environments may be preserved in a bioavailable form, perpetuating prion disease epizootics and exposing other species to the infectious agent

A Search for Very Extended Ionized Gas in Nearby Starburst and Active Galaxies

We report the results from a pilot study of 10 nearby starburst and active galaxies conducted with the Taurus Tunable Filter (TTF) on the Anglo-Australian and William Herschel Telescopes. The main purpose of this imaging survey is to search for warm emission-line gas on the outskirts (galactocentric distances R > 10 kpc) of galaxies to provide direct constraints on the size and geometry of the ``zone of influence'' of these galaxies on their environment. Gaseous complexes or filaments larger than ~ 20 kpc are discovered or confirmed in six of the galaxies in the sample (NGC 1068, NGC 1482, NGC 4388, NGC 6240, NGC 7213, and MR 2251-178). Slightly smaller structures are seen for the first time in the ionization cones and galactic winds of NGC 1365, NGC 1705, Circinus galaxy, and ESO484-G036. The TTF data are combined with new optical long-slit spectra as well as published and archived radio and X-ray maps to constrain the origin and source of ionization of these filaments. A broad range of phenomena is observed, including large-scale ionization cones and galactic winds, tidal interaction, and ram-pressure stripping by an intracluster medium. The source of ionization in this gas ranges from shock ionization to photoionization by the central AGN or in-situ hot young stars. The sample is too small to draw statistically meaningful conclusions about the extent and properties of the warm ionized medium on large scale and its relevance to galaxy formation and evolution. The next generation of tunable filters on large telescopes promises to improve the sensitivity to faint emission-line fluxes at least tenfold and allow systematic surveys of a large sample of emission-line galaxies.Comment: 17 pages + 20 gif figures (high-resolution color version of these gif figures will be available with the electronic version of the published paper). Accepted for publication in the Astronomical Journal, November 2003 issu

Reflections on Seminole Rock: The Past, Present, and Future of Deference to Agency Regulatory Interpretations

Seminole Rock (or Auer) deference has captured the attention of scholars, policymakers, and the judiciary. That is why Notice & Comment, the blog of the Yale Journal on Regulation and the American Bar Association’s Section of Administrative Law & Regulatory Practice, hosted an online symposium from September 12 to September 23, 2016 on the subject. This symposium contains over 20 contributions addressing different aspects of Seminole Rock deference. Topics include: History of Seminole Rock Empirical Examinations of Seminole Rock Understanding Seminole Rock Within Agencies Understanding Seminole Rock as Applied to Tax, Environmental Law, and Criminal Sentencing Why Seminole Rock Matters Should the Supreme Court Overrule Seminole Rock? Would Overruling Seminole Rock Have Unintended Consequences? What Might the Supreme Court Do? What Might Congress Do? The Future of Seminole Roc

Social Gerontology- Integrative and Territorial Aspects: A Citation Analysis of Subject Scatter and Database Coverage

To determine the mix of resources used in social gerontology research, a citation analysis was conducted. A representative sample of citations was selected from three prominent gerontology journals and information was added to determine subject scatter and database coverage for the cited materials. Results indicate that a significant portion of gerontology research, even from a social science perspective, relies roughly equally on medical resources as it does social science resources. Furthermore, there is a small but defined core of literature constituting scholarly “territory” unique to gerontology. Analysis of database indexing indicated that broad, interdisciplinary databases provide more comprehensive coverage of the cited materials than do subject-specific databases

Heterostructures for Optical Devices

Contains research objectives and reports on eight research projects.Joint Services Electronics Program (Contract DAAL03-86-K-0002)Joint Services Electronics Program (Contract DAALO3-89-C-0001)National Science Foundation (Grant EET 87-03404)Charles Stark Draper Laboratory (Contract DL-H-315251)Xerox Corporation FellowshipMIT Fund

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

Although theMYConcogene has been implicated incancer, a systematic assessment of alterations ofMYC, related transcription factors, and co-regulatoryproteins, forming the proximal MYC network (PMN),across human cancers is lacking. Using computa-tional approaches, we define genomic and proteo-mic features associated with MYC and the PMNacross the 33 cancers of The Cancer Genome Atlas.Pan-cancer, 28% of all samples had at least one ofthe MYC paralogs amplified. In contrast, the MYCantagonists MGA and MNT were the most frequentlymutated or deleted members, proposing a roleas tumor suppressors.MYCalterations were mutu-ally exclusive withPIK3CA,PTEN,APC,orBRAFalterations, suggesting that MYC is a distinct onco-genic driver. Expression analysis revealed MYC-associated pathways in tumor subtypes, such asimmune response and growth factor signaling; chro-matin, translation, and DNA replication/repair wereconserved pan-cancer. This analysis reveals insightsinto MYC biology and is a reference for biomarkersand therapeutics for cancers with alterations ofMYC or the PMN

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts