Literature of Societal Trauma: A Study of Literature Following the Holocaust and the Dirty War

This is a study of the tangible effects of societal trauma that manifest themselves in the literature of a community in the years and decades following said traumas. This paper focuses on literature that follows the Holocaust from World War II Germany and the Dirty War from 1970\u27s Argentina

Direct Attachment of 4-Hydroxybenzoic Acid Polymers and Capture Agents to Flat Sheet and Microdialysis Membranes for Improved Mass Transport

Microdialysis (MD) sampling is a diffusion-based separation method which has the ability to sample any analyte that can diffuse across the semi-permeable membrane. However one challenge for MD is that for soluble proteins greater than 10 kDa, the relative recovery (RR) using a 100 kDa MD probe is between 1-5%.1 There are two major barriers that lead to these low recovery values - nonspecific adsorption (NSA) and poor solute mass transport. To overcome these two barriers, the modification of PES-based MD membranes has been initiated by laccase. Previous researchers have used laccase to modify PES flat sheet and hollow fiber membranes using 4HBA to create a hydrophilic polymer chain network.2 Furthermore by functionalizing the MD membranes with carboxylic acid functional groups from 4HBA, one can easily modify the surface.3 This study focuses on characterization of the PES membrane surface before and after attachment of 4HBA polymers and heparin. First the attachment of 4HBA and heparin has been confirmed using XPS and ATR-FTIR. Next protein adsorption measurements were performed for 4HBA modified flat sheets which showed an initial increase in BSA adsorption followed by a decrease in BSA adsorption after 24 hours of modification. However, for positively charged lysozyme the protein adsorption increased upon modification. RR experiments were performed using FITC-labeled dextrans, lysozyme, CCL2, VEGF, TNF-a, KC/GRO and aFGF. After modification with 4HBA for 2 hours, RR of CCL2, KC/GRO, and VEGF increased 2 to 3 times compared to the control relative recovery however, this increase in RR was not observed for aFGF and TNF-a. This difference could be due to the isoelectric points (pI) of these proteins indicating an electrostatic interaction between the surface and the protein. For 24 hour 4HBA-heparin modified membranes CCL2 RR increased twofold for hours 3 and 4 and for 2 hour 4HBA-heparin modified membranes aFGF RR increase threefold

Animal visual culture in the middle ages

This PhD thesis presents an investigation of animal visual culture in the Middle Ages. The term animal visual culture is most simply defined (and intended to be understood as), visual material culture which demonstrates animal/creature-related images or material which becomes circulated in animal/creature forms. The thesis uses an archaeological approach to investigate visualisations of animals (as opposed to a purely zoo-archaeological, historical or art historical approach). Three main types of visual material culture were researched for the representation of animals: stained and painted glass, misericord carvings and portable material culture. The representation of animals in each data source was investigated to explore the extent to which species, chronological, and either geographical or artefact patterns could be established within a 500 year period of the Middle Ages. A number of species, chronological, and either geographical or artefact patterns could be established.It was concluded that the patterns of representations were linked to the ideas various organisations and individuals had about animals or wanted others to have about animals. Animal visual culture is a manifestation of medieval life and faith. It challenges our modern day understanding of the complex medieval issues influencing the creation and intended function of animal images in society

The Effect of Carbon Ink Rheology on Ink Separation Mechanisms in Screen-Printing

Screen-printable carbon-based inks are available in a range of carbon morphologies and concentrations, resulting in various rheological profiles. There are challenges in obtaining a good print when high loading and elasticity functional inks are used, with a trade-off often required between functionality and printability. There is a limited understanding of how ink rheology influences the ink deposition mechanism during screen-printing, which then affects the print topography and therefore electrical performance. High speed imaging was used with a screen-printing simulation apparatus to investigate the effect of viscosity of a graphite and carbon-black ink at various levels of solvent dilution on the deposition mechanisms occurring during screen-printing. With little dilution, the greater relative volume of carbon in the ink resulted in a greater tendency towards elastic behavior than at higher dilutions. During the screen-printing process this led to the ink splitting into filaments while remaining in contact with both the mesh and substrate simultaneously over a greater horizonal length. The location of separating filaments corresponded with localized film thickness increases in the print, which led to a higher surface roughness (Sz). This method could be used to make appropriate adjustments to ink rheology to overcome print defects related to poor ink separation

High-speed imaging the effect of snap-off distance and squeegee speed on the ink transfer mechanism of screen-printed carbon pastes

Screen printing is the most widely used process in the production of printed electronics due to its ability to consistently transfer inks containing a wide range of functional materials onto a range of substrates. However, despite its extensive use, the mechanism by which the ink is transferred through the mesh and onto the substrate is not fully understood. Existing theories are contradictory and lack experimental validation. Therefore, high-speed imaging was used in combination with a screen-printing simulation rig that was designed to provide good optical access to study ink deposition during the screen-printing process. The variation in the four stages of ink flow through the screen, described in the theory by Messerschmitt, has been quantified with respect to changes in snap-off distance and squeegee speed. Analyses of the images were compared with measurements of the ink properties and corroborated with analyses of the prints. This has provided a better understanding of the mechanism by which the ink transfers from the mesh to the substrate and subsequently separates in screen printing. This could be used as the basis for the development of predictive algorithms, as well as to improve the understanding of how to optimize print quality and performance

The influence of carbon morphologies and concentrations on the rheology and electrical performance of screen-printed carbon pastes

Screen-printing inks containing various morphologies of carbon are used in the production of a variety of printed electronics applications. Particle morphology influences the rheology of the ink which will affect the deposition and therefore the electrical performance of a printed component. To assess the effect of both carbon morphology and concentration on print topography and conductivity, screen printable carbon inks with differing loading concentrations of graphite, carbon black and graphite nanoplatelets (GNPs) were formulated, printed and characterised, with rheological and novel print visualisation techniques used to elucidate the mechanisms responsible. Carbon morphology had significant effects on the packing of particles. The smaller carbon black particles had more interparticle interactions leading to better conductivities, but also higher ink viscosities and elasticities than the other morphologies. Increases in carbon concentration led to increases in film thickness and roughness for all morphologies. However, beyond a critical point further increases in carbon concentration led to agglomerations of particles, mesh marking and increases in surface roughness, preventing further improvements in the print conductivity. The optimal loading concentrations were identifiable using a custom-made screen-printing apparatus used with high speed imaging for all morphologies. Notable increases in filamentation during ink separation were found to occur with further increases in carbon concentration beyond the optimum. As this point could not be identified using shear rheology alone, this method combined with shear rheology could be used to optimise the carbon concentration of screen-printing inks, preventing the use of excess material which has no benefit on print quality and conductivity

Implementing educational and systems-level changes to improve cancer screening rates among state employees in Missouri

As of 2022, only 51% of active eligible state employees in Missouri have been screened for colorectal cancer and 67% for breast cancer, despite having state-sponsored health insurance. In fall 2020, the Missouri Department of Health and Senior Services Comprehensive Cancer Program partnered with the Missouri Cancer Consortium to create a strategy to improve cancer screening rates among state employees. The project was designed to include 3 phases: 1) a colorectal cancer education phase, 2) an expanded education phase that included additional cancers, and 3) a proposed intervention phase that will include screening events. In the first phase, in 2020, colorectal cancer educational materials were sent to all state employees. In the second phase, in 2022, educational resources were expanded to include additional cancers and screening tools. In both initiatives, educational materials and information on current screening recommendations were distributed to approximately 40,000 state employees. A database of screening rates was developed to monitor screening rates and challenge state employees to complete screenings. Evidence-informed interventions were implemented with a focus on health equity. We used a regional approach to identify geographic areas with the greatest need. These efforts will support the next phase of the project, which involves planning breast and colorectal cancer screening events. Policy changes will be encouraged to remove systems-level barriers that discourage employees from being screened for cancer. Recommended tools and strategies can be adopted by similar organizations with complex, multitier employee structures

Barriers and outcomes of an evidence-based approach to diagnosis and management of chronic obstructive pulmonary disease (COPD) in Australia: a qualitative study

Background. Chronic obstructive pulmonary disease (COPD) is commonly managed in primary care but there is poor awareness of evidence-based guidelines and the quality and interpretation of spirometry is suboptimal. Objectives. The aims of this qualitative study were to explore how an intervention involving case finding and management of COPD was implemented, and the extent to which the GPs and practice nurses (PNs) worked in partnership to diagnose and manage COPD. Methods. Semi-structured interviews with PNs (n = 7), GPs (n = 4) and patients (n = 26) who had participated in the Primary care EarLy Intervention for Copd mANagement (PELICAN) study. The Theoretical Domains Framework was used to guide the coding and analysis of the interviews with PN and GPs. The patient interviews were analysed thematically. Results. PNs developed technical skills and understood the requirements for good-quality spirometry. However, many lacked confidence in its interpretation and felt this was not part of their professional role. This was reflected in responses from the GPs. Once COPD was diagnosed, the GPs tended to manage the patients with the PNs less involved. This was in contrast with PNs’ active role in managing patients with other chronic diseases such as diabetes. The extent to which the GPs and PNs worked in partnership to manage COPD varied. Conclusions. PNs improved their skills and confidence in performing spirometry. Beliefs about their professional role, identity and confidence influenced the extent to which PNs were involved in interpretation of the spirometry results and managing the patient in partnership with the GP

Implementing the battery-operated hand-held fan as an evidence-based, non-pharmacological intervention for chronic breathlessness in patients with chronic obstructive pulmonary disease (COPD): a qualitative study of the views of specialist respiratory clinicians

INTRODUCTION: The battery-operated hand-held fan ('fan') is an inexpensive and portable non-pharmacological intervention for chronic breathlessness. Evidence from randomised controlled trials suggests the fan reduces breathlessness intensity and improves physical activity in patients with a range of advanced chronic conditions. Qualitative data from these trials suggests the fan may also reduce anxiety and improve daily functioning for many patients. This study aimed to explore barriers and facilitators to the fan's implementation in specialist respiratory care as a non-pharmacological intervention for chronic breathlessness in patients with chronic obstructive pulmonary disease (COPD). METHODS: A qualitative approach was taken, using focus groups. Participants were clinicians from any discipline working in specialist respiratory care at two hospitals. Questions asked about current fan-related practice and perceptions regarding benefits, harms and mechanisms, and factors influencing its implementation. Analysis used a mixed inductive/deductive approach. RESULTS: Forty-nine participants from nursing (n = 30), medical (n = 13) and allied health (n = 6) disciplines participated across 9 focus groups. The most influential facilitator was a belief that the fan's benefits outweighed disadvantages. Clinicians' beliefs about the fan's mechanisms determined which patient sub-groups they targeted, for example anxious or palliative/end-stage patients. Barriers to implementation included a lack of clarity about whose role it was to implement the fan, what advice to provide patients, and limited access to fans in hospitals. Few clinicians implemented the fan for acute-on-chronic breathlessness or in combination with other interventions. CONCLUSION: Implementation of the fan in specialist respiratory care may require service- and clinician-level interventions to ensure it is routinely recommended as a first-line intervention for chronic breathlessness in patients for whom this symptom is of concern, regardless of COPD stage

Failure to Detect Xenotropic Murine Leukemia Virus-Related Virus in Blood of Individuals at High Risk of Blood-Borne Viral Infections

A xenotropic murine leukemia virus-related virus (XMRV) has recently been reported in association with prostate cancer and chronic fatigue syndrome, with a prevalence of up to 3.7% in the healthy population. We looked for XMRV in 230 patients with human immunodeficiency virus type 1 or hepatitis C infection. XMRV was undetectable in plasma or peripheral blood mononuclear cells by polymerase chain reaction targeting XMRV gag or env. T cell responses to XMRV Gag were undetectable in peripheral blood mononuclear cells by ex vivo gamma interferon enzyme-linked immunospot assay. In our cohorts, XMRV was not enriched in patients with blood-borne or sexually transmitted infections fromthe United Kingdom and Western Europ