Wavelength Dependence of Solar Irradiance Enhancement During X-Class Flares and Its Influence on the Upper Atmosphere

The wavelength dependence of solar irradiance enhancement during flare events is one of the important factors in determining how the Thermosphere-Ionosphere (T-I) system responds to flares. To investigate the wavelength dependence of flare enhancement, the Flare Irradiance Spectral Model (FISM) was run for 61 X-class flares. The absolute and the percentage increases of solar irradiance at flare peaks, compared to pre-flare conditions, have clear wavelength dependences. The 0-14 nm irradiance increases much more (approx. 680% on average) than that in the 14-25 nm waveband (approx. 65% on average), except at 24 nm (approx. 220%). The average percentage increases for the 25-105 nm and 122-190 nm wavebands are approx. 120% and approx. 35%, respectively. The influence of 6 different wavebands (0-14 nm, 14-25 nm, 25-105 nm, 105- 120 nm, 121.56 nm, and 122-175 nm) on the thermosphere was examined for the October 28th, 2003 flare (X17-class) event by coupling FISM with the National Center for Atmospheric Research (NCAR) Thermosphere-Ionosphere-Electrodynamics General Circulation Model (TIE-GCM) under geomagnetically quiet conditions (Kp=1). While the enhancement in the 0-14 nm waveband caused the largest enhancement of the globally integrated solar heating, the impact of solar irradiance enhancement on the thermosphere at 400 km is largest for the 25-105 nm waveband (EUV), which accounts for about 33 K of the total 45 K temperature enhancement, and approx. 7.4% of the total approx. 11.5% neutral density enhancement. The effect of 122-175 nm flare radiation on the thermosphere is rather small. The study also illustrates that the high-altitude thermospheric response to the flare radiation at 0-175 nm is almost a linear combination of the responses to the individual wavebands. The upper thermospheric temperature and density enhancements peaked 3-5 h after the maximum flare radiation

Fractalkine receptor (CX3CR1) deficiency sensitizes mice to the behavioral changes induced by lipopolysaccharide

<p>Abstract</p> <p>Background</p> <p>Interactions between fractalkine (CX₃CL1) and fractalkine receptor (CX₃CR1) regulate microglial activation in the CNS. Recent findings indicate that age-associated impairments in CX₃CL1 and CX₃CR1 are directly associated with exaggerated microglial activation and an impaired recovery from sickness behavior after peripheral injection of lipopolysaccharide (LPS). Therefore, the purpose of this study was to determine the extent to which an acute LPS injection causes amplified and prolonged microglial activation and behavioral deficits in CX₃CR1-deficient mice (CX₃CR1^-/-).</p> <p>Methods</p> <p>CX₃CR1^-/-mice or control heterozygote mice (CX₃CR1^+/-) were injected with LPS (0.5 mg/kg i.p.) or saline and behavior (i.e., sickness and depression-like behavior), microglial activation, and markers of tryptophan metabolism were determined. All data were analyzed using Statistical Analysis Systems General Linear Model procedures and were subjected to one-, two-, or three-way ANOVA to determine significant main effects and interactions.</p> <p>Results</p> <p>LPS injection caused a prolonged duration of social withdrawal in CX₃CR1^-/-mice compared to control mice. This extended social withdrawal was associated with enhanced mRNA expression of IL-1β, indolamine 2,3-dioxygenase (IDO) and kynurenine monooxygenase (KMO) in microglia 4 h after LPS. Moreover, elevated expression of IL-1β and CD14 was still detected in microglia of CX₃CR1^-/-mice 24 h after LPS. There was also increased turnover of tryptophan, serotonin, and dopamine in the brain 24 h after LPS, but these increases were independent of CX₃CR1 expression. When submitted to the tail suspension test 48 and 72 h after LPS, an increased duration of immobility was evident only in CX₃CR1^-/-mice. This depression-like behavior in CX₃CR1^-/-mice was associated with a persistent activated microglial phenotype in the hippocampus and prefrontal cortex.</p> <p>Conclusions</p> <p>Taken together, these data indicate that a deficiency of CX₃CR1 is permissive to protracted microglial activation and prolonged behavioral alterations in response to transient activation of the innate immune system.</p

Reexpression of caveolin-1 in endothelium rescues the vascular, cardiac, and pulmonary defects in global caveolin-1 knockout mice

Caveolin-1 (Cav-1) is the principal structural component of caveolae organelles in smooth muscle cells, adipocytes, fibroblasts, epithelial cells, and endothelial cells (ECs). Cav-1–deficient (Cav-1 knockout [KO]) mice are viable and show increases of nitric oxide (NO) production in vasculature, cardiomyopathy, and pulmonary dysfunction. In this study, we generated EC-specific Cav-1–reconstituted (Cav-1 RC) mice and reexamined vascular, cardiac, and pulmonary phenotypes. Cav-1 KO pulmonary arteries had decreased smooth muscle contractility and increased endothelial NO synthase activation and hypotension; the latter two effects were rescued completely in Cav-1 RC mice. Cav-1 KO mice exhibited myocardial hypertrophy, pulmonary hypertension, and alveolar cell hyperproliferation caused by constitutive activation of p42/44 mitogen-activated protein kinase and Akt. Interestingly, in Cav-1 RC mice, cardiac hypertrophy and pulmonary hypertension were completely rescued, whereas alveolar hyperplasia was partially recovered because of the lack of rescue of Cav-1 in bronchiolar epithelial cells. These results provide clear physiological evidence supporting the important role of cell type–specific Cav-1 expression governing multiple phenotypes in the vasculature, heart, and lung

Childhood sleep health and epigenetic age acceleration in late adolescence: Cross-sectional and longitudinal analyses

Aim: Investigate if childhood measures of sleep health are associated with epigenetic age acceleration in late adolescence. Methods: Parent-reported sleep trajectories from age 5 to 17, self-reported sleep problems at age 17, and six measures of epigenetic age acceleration at age 17 were studied in 1192 young Australians from the Raine Study Gen2. Results: There was no evidence for a relationship between the parent-reported sleep trajectories and epigenetic age acceleration (p ≥ 0.17). There was a positive cross-sectional relationship between self-reported sleep problem score and intrinsic epigenetic age acceleration at age 17 (b = 0.14, p = 0.04), which was attenuated after controlling for depressive symptom score at the same age (b = 0.08, p = 0.34). Follow-up analyses suggested this finding may represent greater overtiredness and intrinsic epigenetic age acceleration in adolescents with higher depressive symptoms. Conclusion: There was no evidence for a relationship between self- or parent-reported sleep health and epigenetic age acceleration in late adolescence after adjusting for depressive symptoms. Mental health should be considered as a potential confounding variable in future research on sleep and epigenetic age acceleration, particularly if subjective measures of sleep are used

Reduction of the HIV Protease Inhibitor-Induced ER Stress and Inflammatory Response by Raltegravir in Macrophages

Background HIV protease inhibitor (PI), the core component of highly active antiretroviral treatment (HAART) for HIV infection, has been implicated in HAART-associated cardiovascular complications. Our previous studies have demonstrated that activation of endoplasmic reticulum (ER) stress is linked to HIV PI-induced inflammation and foam cell formation in macrophages. Raltegravir is a first-in-its-class HIV integrase inhibitor, the newest class of anti-HIV agents. We have recently reported that raltegravir has less hepatic toxicity and could prevent HIV PI-induced dysregulation of hepatic lipid metabolism by inhibiting ER stress. However, little information is available as to whether raltegravir would also prevent HIV PI-induced inflammatory response and foam cell formation in macrophages. Methodology and Principal Findings In this study, we examined the effect of raltegravir on ER stress activation and lipid accumulation in cultured mouse macrophages (J774A.1), primary mouse macrophages, and human THP-1-derived macrophages, and further determined whether the combination of raltegravir with existing HIV PIs would potentially exacerbate or prevent the previously observed activation of inflammatory response and foam cell formation. The results indicated that raltegravir did not induce ER stress and inflammatory response in macrophages. Even more interestingly, HIV PI-induced ER stress, oxidative stress, inflammatory response and foam cell formation were significantly reduced by raltegravir. High performance liquid chromatography (HPLC) analysis further demonstrated that raltegravir did not affect the uptake of HIV PIs in macrophages. Conclusion and Significance Raltegravir could prevent HIV PI-induced inflammatory response and foam cell formation by inhibiting ER stress. These results suggest that incorporation of this HIV integrase inhibitor may reduce the cardiovascular complications associated with current HAART

Modeling Caricature Expressions by 3D Blendshape and Dynamic Texture

The problem of deforming an artist-drawn caricature according to a given normal face expression is of interest in applications such as social media, animation and entertainment. This paper presents a solution to the problem, with an emphasis on enhancing the ability to create desired expressions and meanwhile preserve the identity exaggeration style of the caricature, which imposes challenges due to the complicated nature of caricatures. The key of our solution is a novel method to model caricature expression, which extends traditional 3DMM representation to caricature domain. The method consists of shape modelling and texture generation for caricatures. Geometric optimization is developed to create identity-preserving blendshapes for reconstructing accurate and stable geometric shape, and a conditional generative adversarial network (cGAN) is designed for generating dynamic textures under target expressions. The combination of both shape and texture components makes the non-trivial expressions of a caricature be effectively defined by the extension of the popular 3DMM representation and a caricature can thus be flexibly deformed into arbitrary expressions with good results visually in both shape and color spaces. The experiments demonstrate the effectiveness of the proposed method.Comment: Accepted by the 28th ACM International Conference on Multimedia (ACM MM 2020

Broadband Thermal Imaging using Meta-Optics

Subwavelength diffractive optics known as meta-optics have demonstrated the potential to significantly miniaturize imaging systems. However, despite impressive demonstrations, most meta-optical imaging systems suffer from strong chromatic aberrations, limiting their utilities. Here, we employ inverse-design to create broadband meta-optics operating in the long-wave infrared (LWIR) regime (8 - 12 $\mu$m). Via a deep-learning assisted multi-scale differentiable framework that links meta-atoms to the phase, we maximize the wavelength-averaged volume under the modulation transfer function (MTF) of the meta-optics. Our design framework merges local phase-engineering via meta-atoms and global engineering of the scatterer within a single pipeline. We corroborate our design by fabricating and experimentally characterizing all-silicon LWIR meta-optics. Our engineered meta-optic is complemented by a simple computational backend that dramatically improves the quality of the captured image. We experimentally demonstrate a six-fold improvement of the wavelength-averaged Strehl ratio over the traditional hyperboloid metalens for broadband imaging.Comment: 28 pages, 12 figure

Tellurium substitution effect on superconductivity of the alpha-phase Iron Selenide

We have carried out a systematic study of the PbO-type compound FeSe_{1-x}Te_x (x = 0~1), where Te substitution effect on superconductivity is investigated. It is found that superconducting transition temperature reaches a maximum of Tc=15.2K at about 50% Te substitution. The pressure-enhanced Tc of FeSe0.5Te0.5 is more than 10 times larger than that of FeSe. Interestingly, FeTe is no longer superconducting. A low temperature structural distortion changes FeTe from triclinic symmetry to orthorhombic symmetry. We believe that this structural change breaks the magnetic symmetry and suppresses superconductivity in FeTe.Comment: Some typing errors are corrected; we take out one figures, now the paper has 14 pages, 5 figure

DeepFacePencil: Creating Face Images from Freehand Sketches

In this paper, we explore the task of generating photo-realistic face images from hand-drawn sketches. Existing image-to-image translation methods require a large-scale dataset of paired sketches and images for supervision. They typically utilize synthesized edge maps of face images as training data. However, these synthesized edge maps strictly align with the edges of the corresponding face images, which limit their generalization ability to real hand-drawn sketches with vast stroke diversity. To address this problem, we propose DeepFacePencil, an effective tool that is able to generate photo-realistic face images from hand-drawn sketches, based on a novel dual generator image translation network during training. A novel spatial attention pooling (SAP) is designed to adaptively handle stroke distortions which are spatially varying to support various stroke styles and different levels of details. We conduct extensive experiments and the results demonstrate the superiority of our model over existing methods on both image quality and model generalization to hand-drawn sketches.Comment: ACM MM 2020 (oral