Understanding quantization: a hidden variable model

We argue that to solve the foundational problems of quantum theory one has to first understand what it means to quantize a classical system. We then propose a quantization method based on replacement of deterministic c-numbers by stochastically-parameterized c-numbers. Unlike canonical quantization, the method is free from operator ordering ambiguity and the resulting quantum system has a straightforward interpretation as statistical modification of ensemble of classical trajectories. We then develop measurement without wave function collapse \`a la pilot-wave theory and point out new testable predictions.Comment: 16 pages, based on a talk given at "Emergent Quantum Mechanics (Heinz von Foerster Conference 2011)", see http://iopscience.iop.org/1742-6596/361/

Grounding Bohmian Mechanics in Weak Values and Bayesianism

Bohmian mechanics (BM) is a popular interpretation of quantum mechanics in which particles have real positions. The velocity of a point x in configuration space is defined as the standard probability current j(x) divided by the probability density P(x). However, this ``standard'' j is in fact only one of infinitely many that transform correctly and satisfy \dot P + \del . j=0. In this article I show that there is a unique j that can be determined experimentally as a weak value using techniques that would make sense to a classical physicist. Moreover, this operationally defined j equals the standard j, so, assuming \dot x = j/P, the possible Bohmian paths can also be determined experimentally from a large enough ensemble. Furthermore, this approach to deriving BM singles out x as the hidden variable, because (for example) the operationally defined momentum current is in general incompatible with the evolution of the momentum distribution. Finally I discuss how, in this setting, the usual quantum probabilities can be derived from a Bayesian standpoint, via the principle of indifference.Comment: 11 page

Spin-dependent Bohm trajectories associated with an electronic transition in hydrogen

The Bohm causal theory of quantum mechanics with spin-dependence is used to determine electron trajectories when a hydrogen atom is subjected to (semi-classical) radiation. The transition between the 1s ground state and the 2p0 state is examined. It is found that transitions can be identified along Bohm trajectories. The trajectories lie on invariant hyperboloid surfaces of revolution in R^3. The energy along the trajectories is also discussed in relation to the hydrogen energy eigenvalues.Comment: 18 pages, 8 figure

3D meso-scale modelling of concrete material in spall tests

Tensile strength is one of the key factors of concrete material that need be accurately defined in analysis of concrete structures subjected to high-speed impact loads. Dynamic tensile strength of concrete material is usually obtained by conducting laboratory tests such as direct tensile test, Brazilian splitting test and spall test. Concrete is a heterogeneous material with different components, but is conventionally assumed to be homogeneous, i.e., cement mortar only, in most previous experimental or numerical studies. The aggregates in concrete material are usually neglected owing to testing limitation and numerical simplification. It has been well acknowledged that neglecting coarse aggregates might not necessarily give accurate concrete dynamic material properties. In the present study, a 3D meso-scale model of concrete specimen with consideration of cement mortar and aggregates is developed to simulate spall tests and investigate the behaviour of concrete material under high strain rate. The commercial software LS-DYNA is used to perform the numerical simulations of spall tests. The mesh size sensitivity is examined by conducting mesh convergence tests. The reliability of the numerical model in simulating the spall tests is verified by comparing the numerical results with the experimental data from the literature. The influence of coarse aggregates on the experimental test results is studied. The wave attenuation in concrete specimen is analysed, and empirical equations are proposed for quick assessment of the test data to determine the true dynamic tensile strength of concrete material. The contributions of aggregates to dynamic strength in spall tests are quantified for modifying the test results based on mortar material in the literature

Differential Expression of CD163 on Monocyte Subsets in Healthy and HIV-1 Infected Individuals

CD163, a haptoglobin-hemoglobin (Hp-Hb) scavenger receptor, expressed by monocytes and macrophages, is important in resolution of inflammation. Age-related non-AIDS co-morbidities in HIV-infected individuals, particularly dementia and cardiovascular disease, result in part from effects of HIV-1 infection on monocyte and macrophage biology. CD163 co-expression on CD14+CD16++ monocytes has been proposed as a useful biomarker for HIV-1 disease progression and the presence of HIV associated dementia. Here we investigated CD163 expression on monocyte subsets ex vivo, on cultured macrophages, and soluble in plasma, in the setting of HIV-1 infection. Whole blood immunophenotyping revealed CD163 expression on CD14++CD16- monocytes but not on CD14+CD16++ monocytes (P = 0.004), supported by CD163 mRNA levels. Incubation with M-CSF induced CD163 protein expression on CD14+CD16++ monocytes to the same extent as CD14++CD16− monocytes. CD163 expression on CD14++CD16+ monocytes from HIV-infected subjects was significantly higher than from uninfected individuals, with a trend towards increased expression on CD14++CD16− monocytes (P = 0.019 and 0.069 respectively), which is accounted for by HIV-1 therapy including protease inhibitors. Shedding of CD163 was shown to predominantly occur from the CD14++CD16− subset after Ficoll isolation and LPS stimulation. Soluble CD163 concentration in plasma from HIV-1 infected donors was similar to HIV-1 uninfected donors. Monocyte CD163 expression in HIV-1 infected patients showed a complicated relationship with classical measures of disease progression. Our findings clarify technical issues regarding CD163 expression on monocyte subsets and further elucidates its role in HIV-associated inflammation by demonstrating that CD163 is readily lost from CD14++CD16− monocytes and induced in pro-inflammatory CD14+CD16++ monocytes by M-CSF. Our data show that all monocyte subsets are potentially capable of differentiating into CD163-expressing anti-inflammatory macrophages given appropriate stimuli. Levels of CD163 expression on monocytes may be a potential biomarker reflecting efforts by the immune system to resolve immune activation and inflammation in HIV-infected individuals

Differential Expression of CD163 on Monocyte Subsets in Healthy and HIV-1 Infected Individuals

CD163, a haptoglobin-hemoglobin (Hp-Hb) scavenger receptor, expressed by monocytes and macrophages, is important in resolution of inflammation. Age-related non-AIDS co-morbidities in HIV-infected individuals, particularly dementia and cardiovascular disease, result in part from effects of HIV-1 infection on monocyte and macrophage biology. CD163 co-expression on CD14+CD16++ monocytes has been proposed as a useful biomarker for HIV-1 disease progression and the presence of HIV associated dementia. Here we investigated CD163 expression on monocyte subsets ex vivo, on cultured macrophages, and soluble in plasma, in the setting of HIV-1 infection. Whole blood immunophenotyping revealed CD163 expression on CD14++CD16- monocytes but not on CD14+CD16++ monocytes (P = 0.004), supported by CD163 mRNA levels. Incubation with M-CSF induced CD163 protein expression on CD14+CD16++ monocytes to the same extent as CD14++CD16− monocytes. CD163 expression on CD14++CD16+ monocytes from HIV-infected subjects was significantly higher than from uninfected individuals, with a trend towards increased expression on CD14++CD16− monocytes (P = 0.019 and 0.069 respectively), which is accounted for by HIV-1 therapy including protease inhibitors. Shedding of CD163 was shown to predominantly occur from the CD14++CD16− subset after Ficoll isolation and LPS stimulation. Soluble CD163 concentration in plasma from HIV-1 infected donors was similar to HIV-1 uninfected donors. Monocyte CD163 expression in HIV-1 infected patients showed a complicated relationship with classical measures of disease progression. Our findings clarify technical issues regarding CD163 expression on monocyte subsets and further elucidates its role in HIV-associated inflammation by demonstrating that CD163 is readily lost from CD14++CD16− monocytes and induced in pro-inflammatory CD14+CD16++ monocytes by M-CSF. Our data show that all monocyte subsets are potentially capable of differentiating into CD163-expressing anti-inflammatory macrophages given appropriate stimuli. Levels of CD163 expression on monocytes may be a potential biomarker reflecting efforts by the immune system to resolve immune activation and inflammation in HIV-infected individuals

East Coast Fever Caused by Theileria parva Is Characterized by Macrophage Activation Associated with Vasculitis and Respiratory Failure

Respiratory failure and death in East Coast Fever (ECF), a clinical syndrome of African cattle caused by the apicomplexan parasite Theileria parva, has historically been attributed to pulmonary infiltration by infected lymphocytes. However, immunohistochemical staining of tissue from T. parva infected cattle revealed large numbers of CD3- and CD20-negative intralesional mononuclear cells. Due to this finding, we hypothesized that macrophages play an important role in Theileria parva disease pathogenesis. Data presented here demonstrates that terminal ECF in both Holstein and Boran cattle is largely due to multisystemic histiocytic responses and resultant tissue damage. Furthermore, the combination of these histologic changes with the clinical findings, including lymphadenopathy, prolonged pyrexia, multi-lineage leukopenia, and thrombocytopenia is consistent with macrophage activation syndrome. All animals that succumbed to infection exhibited lymphohistiocytic vasculitis of small to medium caliber blood and lymphatic vessels. In pulmonary, lymphoid, splenic and hepatic tissues from Holstein cattle, the majority of intralesional macrophages were positive for CD163, and often expressed large amounts of IL-17. These data define a terminal ECF pathogenesis in which parasite-driven lymphoproliferation leads to secondary systemic macrophage activation syndrome, mononuclear vasculitis, pulmonary edema, respiratory failure and death. The accompanying macrophage phenotype defined by CD163 and IL-17 is presented in the context of this pathogenesis