Receiver operating characteristic (ROC) curves of transoesophageal echocardiography (TEE) Doppler parameters to predict an invasive pulmonary artery occlusion pressure (PAOP) ≤ 18 mmHg in protocol A

Left panel: area under the curves (AUC) with standard error and 95% confidence intervals (CI) and p values (comparison of the actual AUC with the 0.50 AUC) of mitral Doppler parameters were as follows: E/A, 0.83 ± 0.09 (95% CI: 0.70–0.92; p = 0.0002); mitral E wave deceleration time, 0.81 ± 0.07 (95% CI: 0.67–0.90; p < 0.0001); atrial filling fraction: 0.82 ± 0.07 (95% CI: 0.68–0.91; p < 0.0001). Right panel: AUC with standard error and 95% CI of pulmonary vein Doppler parameters were the followings: S/D, 0.78 ± 0.07 (95% CI: 0.65–0.88; p = 0.0001); systolic fraction, 0.84 ± 0.06 (95% CI: 0.72–0.93; p < 0.0001). Abbreviations: AFF, atrial filling fraction; DT, deceleration time of early diastolic mitral E wave; SF, systolic fraction.<p><b>Copyright information:</b></p><p>Taken from "Echocardiographic assessment of pulmonary artery occlusion pressure in ventilated patients: a transoesophageal study"</p><p>http://ccforum.com/content/12/1/R18</p><p>Critical Care 2008;12(1):R18-R18.</p><p>Published online 19 Feb 2008</p><p>PMCID:PMC2374607.</p><p></p

Additional file 4: Table S2. of Severe varicella-zoster virus pneumonia: a multicenter cohort study

Univariate analysis of patient characteristics associated with hospital mortality. (DOC 39 kb

Additional file 3: Table S3. of Severe varicella-zoster virus pneumonia: a multicenter cohort study

Mortality evolution during the study period. (DOC 28 kb

Additional file 5: Figure S2. of Severe varicella-zoster virus pneumonia: a multicenter cohort study

Influence of age on mortality in patients with VZV pneumonia. (TIFF 675 kb

Additional file 1: Table S1. of Severe varicella-zoster virus pneumonia: a multicenter cohort study

Participating centers (n = 29) with the number of cases of VZV pneumonia during the study period (1996–2016). (DOC 45 kb

Additional file 6: Figure S3. of Severe varicella-zoster virus pneumonia: a multicenter cohort study

Influence of underlying immunosuppression on mortality in patients with VZV pneumonia. (PDF 1968 kb

Effects of hypothermia vs normothermia on societal participation and cognitive function at 6 months in survivors after out-of-hospital cardiac arrest

Importance: The Targeted Hypothermia vs Targeted Normothermia After Out-of-Hospital Cardiac Arrest (TTM2) trial reported no difference in mortality or poor functional outcome at 6 months after out-of-hospital cardiac arrest (OHCA). This predefined exploratory analysis provides more detailed estimation of brain dysfunction for the comparison of the 2 intervention regimens. Objectives: To investigate the effects of targeted hypothermia vs targeted normothermia on functional outcome with focus on societal participation and cognitive function in survivors 6 months after OHCA. Design, Setting, and Participants: This study is a predefined analysis of an international multicenter, randomized clinical trial that took place from November 2017 to January 2020 and included participants at 61 hospitals in 14 countries. A structured follow-up for survivors performed at 6 months was by masked outcome assessors. The last follow-up took place in October 2020. Participants included 1861 adult (older than 18 years) patients with OHCA who were comatose at hospital admission. At 6 months, 939 of 1861 were alive and invited to a follow-up, of which 103 of 939 declined or were missing. Interventions: Randomization 1:1 to temperature control with targeted hypothermia at 33 °C or targeted normothermia and early treatment of fever (37.8 °C or higher). Main outcomes and measures: Functional outcome focusing on societal participation assessed by the Glasgow Outcome Scale Extended ([GOSE] 1 to 8) and cognitive function assessed by the Montreal Cognitive Assessment ([MoCA] 0 to 30) and the Symbol Digit Modalities Test ([SDMT] z scores). Higher scores represent better outcomes.ResultsAt 6 months, 836 of 939 survivors with a mean age of 60 (SD, 13) (range, 18 to 88) years (700 of 836 male [84%]) participated in the follow-up. There were no differences between the 2 intervention groups in functional outcome focusing on societal participation (GOSE score, odds ratio, 0.91; 95% CI, 0.71-1.17; P = .46) or in cognitive function by MoCA (mean difference, 0.36; 95% CI,−0.33 to 1.05; P = .37) and SDMT (mean difference, 0.06; 95% CI,−0.16 to 0.27; P = .62). Limitations in societal participation (GOSE score less than 7) were common regardless of intervention (hypothermia, 178 of 415 [43%]; normothermia, 168 of 419 [40%]). Cognitive impairment was identified in 353 of 599 survivors (59%).ConclusionsIn this predefined analysis of comatose patients after OHCA, hypothermia did not lead to better functional outcome assessed with a focus on societal participation and cognitive function than management with normothermia. At 6 months, many survivors had not regained their pre-arrest activities and roles, and mild cognitive dysfunction was common.</p