12,165 research outputs found

    B cell responses in murine influenza

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    Mining topological relations from the web

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    Topological relations between geographic regions are of interest in many applications. When the exact boundaries of regions are not available, such relations can be established by analysing natural language information from web documents. In particular we demonstrate how redundancy-based techniques can be used to acquire containment and adjacency relations, and how fuzzy spatial reasoning can be employed to maintain the consistency of the resulting knowledge base

    Growth-induced mass flows in fungal networks

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    Cord-forming fungi form extensive networks that continuously adapt to maintain an efficient transport system. As osmotically driven water uptake is often distal from the tips, and aqueous fluids are incompressible, we propose that growth induces mass flows across the mycelium, whether or not there are intrahyphal concentration gradients. We imaged the temporal evolution of networks formed by Phanerochaete velutina, and at each stage calculated the unique set of currents that account for the observed changes in cord volume, while minimising the work required to overcome viscous drag. Predicted speeds were in reasonable agreement with experimental data, and the pressure gradients needed to produce these flows are small. Furthermore, cords that were predicted to carry fast-moving or large currents were significantly more likely to increase in size than cords with slow-moving or small currents. The incompressibility of the fluids within fungi means there is a rapid global response to local fluid movements. Hence velocity of fluid flow is a local signal that conveys quasi-global information about the role of a cord within the mycelium. We suggest that fluid incompressibility and the coupling of growth and mass flow are critical physical features that enable the development of efficient, adaptive, biological transport networks.Comment: To be published in PRSB. 20 pages, plus 8 pages of supplementary information, and 3 page bibliograph

    Twentieth-century Trends in the Annual Cycle of Temperature across the Northern Hemisphere

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    The annual cycle of surface air temperature is examined across Northern Hemisphere land areas (north of 25°N) by comparing the results from CRUTS against four reanalysis datasets: two versions of the Twentieth Century Reanalysis (20CR and 20CRC) and two versions of the ERA-CLIM reanalyses (ERA-20C and ERA-20CM). The Modulated Annual Cycle is adaptively derived from an Ensemble Empirical Mode Decomposition (EEMD) filter, and is used to define the phase and amplitude of the annual cycle. The EEMD method does not impose a simple sinusoidal shape of the annual cycle. None of the reanalysis simulations assimilate surface temperature data, but differ in the parameters that are included: both ERA-20C and 20CR assimilate surface pressure data; ERA-20C also includes surface wind data over the oceans; ERA-20CM does not assimilate any of these synoptic data; and none of the reanalyses assimilate land-use data. It is demonstrated that synoptic variability is critical for explaining the trends and variability of the annual cycle of surface temperature across the northern hemisphere. The CMIP5 forcings alone are insufficient to explain the observed trends and decadal-scale variability, particularly with respect to the decline in the amplitude of the annual cycle throughout the twentieth century. The variability in the annual cycle during the latter half of the twentieth century was unusual in the context of the twentieth century, and was most likely related to large-scale atmospheric variability, although uncertainty in the results is greatest before ca. 1930

    A persistence model of the national minimum wage

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    This paper utilises the panel element of the BHPS (waves 9 to 14) to examine the dynamics of the National Minimum Wage (NMW) introduced to Britain in 1999. Specifically a persistence measure based on a random effects probit model for those affected by the NMW is constructed. The conditional probabilities imply some degree of state dependence, but there is also a considerable amount of turnover from one year to the next among those affected by the NM

    The dynamics of the national minimum wage: transitions between different labour market states

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    An important policy issue is whether the National Minimum Wage (NMW) introduced in Britain in April 1999, is a stepping stone to higher wages or traps workers in a low-wage no-wage cycle. In this paper we utilise the longitudinal element of the Labour Force Survey over the period 1999 to 2003 to model transitions between different labour market states payment at or below the NMW, above the NMW, unemployment and inactivity, using a multinomial logit approach. It appears that for many workers payment at or below the NMW is of relatively short duration and a substantial number move into higher paid jobs
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