New ΔR for the southwest Pacific Ocean

ΔR results of known-age shells from the Solomon and Coral Seas and the northwest coast of New Ireland are presented. The results are too few to be conclusive but indicate that ΔR in this region is variable. An average ΔR value of 370 ± 25 yr is recorded for a range of shell species from Kavieng Harbor, New Ireland, and is primarily attributed to weak equatorial upwelling of depleted 14C due to seasonal current reversals. In contrast, values from the Solomon and Coral Seas are lower (average ΔR = 45 ± 19 yr). Higher ΔR values for some shellfish from these 2 seas is attributed to ingestion of 14Cdepleted sediment by deposit-feeding species

Judo course includes psychology

A self defense course for women stressing psychology and some judo will be one of several programs offered this semester by the Office of Women\u27s Programs and Services, Ellen Weissman, OWPS coordinator said. Weissman said the course will stress the psychological element of self defense along with the physical. The course is being co-instructed by Judo brown belt Tom Probert and psychiatrist Dr. Larry Selversen

The marine ΔR For Nenumbo (Solomon Islands): A case study in calculating reservoir offsets form paired sample data

It is necessary to calculate location-specific marine ΔR values in order to calibrate marine samples using calibration curves such as those provided through the IntCal98 (Stuiver et al. 1998) data. Where known-age samples are available, this calculation is straightforward (i.e. Stuiver et al. 1986). In the case that a paired marine/terrestrial sample calculation is performed, however, the standard calculation (i.e. Stuiver and Braziunas 1993) requires that the samples are treated as relating to isochronous events. This may not be an appropriate assumption for many archaeological paired samples. In this paper, we present an approach to calculating marine ΔR values that does not require the dated events to be treated as isochronous. When archaeological evidence allows the dated events to be tightly temporally constrained, the approach presented here and that described by Stuiver and Braziunas (1993) give very similar results. However, where tight temporal constraints are less certain, the 2 approaches can give rise to differing results. The example analysis considered here shows that a ΔR of –81 ± 64 ¹⁴C yr is appropriate for samples in the vicinity of Nenumbo (Reef Islands, southeast Solomon Islands) around the period 2000–3000 BP

Visual and refractive outcome of one-site phacotrabeculectomy compared with temporal approach phacoemulsification

Background We aimed to compare visual and refractive outcome following phacoemulsification and intraocular lens implant (IOL) and combined one-site phacotrabeculectomy. Method We performed a retrospective study of case records of patients who had temporal incision phacoemulsification with IOL or one-site phacotrabeculectomy, between June 1997 and June 2001. The patients were matched for age group, operating list and IOL type. All patients were operated on under local anesthesia by the same surgeon. Each arm of the study had 90 patients, age range 60 to 75 years. We collected pre- and postoperative visual acuity, pre- and postoperative refraction within six months after surgery, and intended refraction. The intraocular pressure control was not recorded, as it was not the aim of our study. Results In the phacotrabeculectomy group, 76.6% of patients achieved aimed spherical equivalent, 15.5% of patients had against-the-rule (ATR) astigmatism induced by the surgery, and 90% of the patients had best corrected visual acuity (BCVA) more than 6/12. In the temporal incision phacoemulsification group, 81.1% of patients achieved aimed spherical equivalent, 10% of the patients had induced ATR by the surgery and 95.55% of patients achieved BCVA more than 6/12. Conclusion In this study the visual outcome of the phacotrabeculectomy group did not differ significantly from the visual outcome of temporal approach phacoemulsification

Pathways into Leadership: A study of YouthBuild Graduates

The study was conducted by surveying a diverse sample of 344 YouthBuild alumni and conducting extensive interviews with 54 graduates. It demonstrates that YouthBuild has had a profound effect in developing the leadership skills and civic engagement of young people

Metabolomic and Proteomic Stratification of Equine Osteoarthritis

Osteoarthritis (OA) is characterised by loss of articular cartilage, synovial membrane dysfunction and subchondral sclerosis. Few studies have used a global approach to stratify equine synovial fluid (SF) molecular profiles according to OA severity. SF was collected from 58 metacarpophalangeal (MCP) and metatarsophalangeal joints of racing Thoroughbred horses (Hong Kong Jockey Club; HKJC) and 83 MCP joints of mixed breed horses from an abattoir and equine hospital (biobank). Joints were histologically and macroscopically assessed for OA severity. For proteomic analysis, native SF and SF loaded onto ProteoMiner™ equalisation columns, to deplete high abundant proteins, were analysed using liquid chromatography-tandem mass spectrometry (LC-MS/MS) and label-free quantification. Validation of selected differentially expressed proteins was undertaken using clinical SF collected during diagnostic investigations. Native SF metabolites were analysed using 1D 1 H Nuclear Magnetic Resonance (NMR). 1,834 proteins and 40 metabolites were identified in equine SF. Afamin levels decreased with synovitis severity and four uncharacterised proteins decreased with OA severity. Gelsolin and lipoprotein binding protein decreased with OA severity and apolipoprotein A1 levels increased for mild and moderate OA. Within the biobank, glutamate levels decreased with OA severity and for the HKJC cohort, 2-aminobutyrate, alanine and creatine increased with severity. Proteomic and metabolomic integration was undertaken using linear regression via Lasso penalisation modelling, incorporating 29 variables (R 2 =0.82) with principal component 2 able to discriminate advanced OA from earlier stages, predominantly driven by H9GZQ9, F6ZR63 and alanine. Combining biobank and HKJC datasets, discriminant analysis of principal components modelling prediction was good for mild OA (90%). This study has stratified equine OA using both metabolomic and proteomic SF profiles and identified a panel of markers of interest which may be applicable to grading OA severity. This is also the first study to undertake computational integration of NMR metabolomic and LC-MS/MS proteomic datasets of any biological system