The concealed Caledonide basement of eastern England and the southern North Sea : a review

Field mapping, analysis of borehole core and studies of geophysical potential field and seismic data can be used to demonstrate the existence of a number of distinct crustal blocks within Eastern Avalonia beneath eastern England and the southern North Sea. At the core of these blocks is the Midlands Microcraton which is flanked by Ordovician volcanic arc complexes exposed in Wales and the Lake District. A possible volcanic arc complex of comparable age in eastern England is concealed by late Palaeozoic and Mesozoic cover. These volcanic arc complexes resulted from subduction of oceanic lithosphere beneath Avalonia prior to collision with Baltica and Laurentia in late Ordovician and Silurian time, respectively. The nature of the crust north and east of the concealed Caledonides of Eastern England and south of the lapetus Suture/Tornquist Sea Suture, which forms the basement to the southern North Sea, is unclear. Late Ordovician metamorphic ages from cores penetrating deformed metasedimentary rocks on the Mid-North Sea High suggest these rocks were involved in Avalonia-Baltica collision before final closure of the lapetus Ocean between Laurentia and Avalonia

U-Pb geochronology and global context of the Charnian Supergroup, UK: constraints on the age of key Ediacaran fossil assemblages

U-Pb (zircon) ages for key stratigraphic volcanic horizons within the ∼3200-m-thick Ediacaran-age Charnian Supergroup provide an improved age model for the included Avalonian assemblage macrofossils and, hence, temporal constraints essential for intercomparisons of the Charnian fossils with other Ediacaran fossil assemblages globally. The Ives Head Formation (Blackbrook Group), the oldest exposed part of the volcaniclastic Charnian Supergroup of the late Neoproterozoic Avalonian volcanic arc system of southern Britain, contains a bedding plane with an impoverished assemblage of ivesheadiomorphs that is constrained to between ca. 611 Ma and 569.1 ± 0.9 Ma (total uncertainty). Higher-diversity biotas, including the holotypes of Charnia, Charniodiscus, and Bradgatia, occupy the upper part of the volcaniclastic succession (Maplewell Group) and are dated at 561.9 ± 0.9 Ma (total uncertainty) and younger by zircons interpreted as coeval with eruption and deposition of the Park Breccia, Bradgate Formation. An ashy volcanic-pebble conglomerate in the Hanging Rocks Formation at the very top of the supergroup yielded two U-Pb zircon populations: an older detrital one at ca. 604 Ma, and a younger population at ca. 557 Ma, which is interpreted as the approximate depositional age. The temporal association of the fossiliferous Charnian Supergroup with comparable fossiliferous deep-water successions in Newfoundland, and the probable temporal overlap of the youngest Charnwood macrofossils with those from different paleoenvironmental settings, such as the Ediacaran White Sea macrofossils, indicate a primary role for ecological sensitivity in determining the composition of these late Neoproterozoic communities

Sustainability in Turbulent Times: Lessons from the Nexus Network for supporting transdisciplinary research

This is the final version. Available from the Nexus Network via the link in this recordEconomic and Social Research Council (ESRC

National geological screening : East Anglia region

This report is the published product of one of a series of studies covering England, Wales and Northern Ireland commissioned by Radioactive Waste Management (RWM) Ltd. The report provides geological information about the East Anglia region to underpin the process of national geological screening set out in the UK’s government White Paper Implementing geological disposal: a framework for the long-term management of higher activity radioactive waste (DECC, 2014). The report describes geological features relevant to the safety requirements of a geological disposal facility (GDF) for radioactive waste emplaced onshore and up to 20 km offshore at depths between 200 and 1000 m from surface. It is written for a technical audience but is intended to inform RWM in its discussions with communities interested in finding out about the potential for their area to host a GDF

The history of AIDS exceptionalism

In the history of public health, HIV/AIDS is unique; it has widespread and long-lasting demographic, social, economic and political impacts. The global response has been unprecedented. AIDS exceptionalism - the idea that the disease requires a response above and beyond "normal" health interventions - began as a Western response to the originally terrifying and lethal nature of the virus. More recently, AIDS exceptionalism came to refer to the disease-specific global response and the resources dedicated to addressing the epidemic. There has been a backlash against this exceptionalism, with critics claiming that HIV/AIDS receives a disproportionate amount of international aid and health funding

The Geology and Geophysics of the United Arab Emirates. Volume 6, Geology of the western and central United Arab Emirates

This volume forms part of the product of a multidisciplinary study by the British Geological Survey (BGS), commissioned by the UAE Federal Government, Ministry of Energy, to produce 1:100 000 scale geological maps of the bedrock and superficial geology of the central and western part of the UAE. 1:50 000 scale maps were produced of selected areas near Abu Dhabi and for seven emergent salt domes (mainly on offshore islands). This document therefore follows on from the previous volume (Styles et al., 2006) on the geology of the northern Emirates. The present volume similarly contains information about the findings of the geological mapping and associated specialist research. Much of the central and western part of the UAE is blanketed by Quaternary and recent dune sands, fluvial sediments and sabkhas. The only significant areas of exposed older rocks occur along the coast between Abu Dhabi and As Sila and on the various salt islands. Previous geological maps were made more than 20 years ago and were based largely on air photo interpretation with limited ground-truthing. The rapid economic development in the intervening period has seen a tremendous expansion of the national infrastructure and this has greatly increased the demand for high quality, field-based geological maps. The area was mapped at a scale of 1:50 000 and maps produced at 1:100 000, with the exception of the salt dome islands which were mapped at 1:25 000 scale. An area of the coast around Abu Dhabi is illustrated in two additional maps produced at 1:50 000 scale. Each 1:100 000 scale map is accompanied by a Sheet Explanation that describes the rock sequences in the area covered by that particular map. This report describes the broader features of the main rock groups on a regional basis and includes the results of the specialist laboratory studies that were used to define and interpret the geology of the project area. The field mapping was undertaken in the winter months between October 2008 and March 2011. The mapping was carried out by A R Farrant, R A Ellison, R J Thomas, J W Merritt, S J Price, A J Newell, J Merritt, J R Lee, A B Leslie, H F Burke, R A Smith, K M Goodenough, A Finlayson, C J Jordan and S L B Arkley. The laboratory studies were mostly carried out at the BGS. The petrographic study of the Miocene and Quaternary rocks and sediments was carried out by E R Phillips, whilst the igneous petrology of the Hormuz Complex rocks was undertaken by members of the mapping team. I P Wilkinson undertook micropalaeontologial determinations of both Miocene and recent sediments. The macropalaeontology of the basal Baynunah Formation is based largely on published information provided by Dr Mark Beech, Professor Andrew Hill and Dr Faisal Bibi. Some additional data on the Fars Group was provided by M A Woods. R Knox did the heavy mineral analyses, whilst D Wagner and S Kemp worked on the XRD analysis. The U-Pb zircon and carbonate geochronology was undertaken by M Horstwood, N Roberts and R Parrish at the NERC Isotope Geoscience Laboratories at the BGS, Keyworth. The Optically Stimulated Luminescence (OSL) dating was carried out by Professor G Duller and Dr H Roberts in the Aberystwyth Luminescence Research Laboratory at the Institute of Geography and Earth Sciences, Aberystwyth University. P Turner and C Simpson were responsible for the GIS systems and map layouts. H Holbrook and S Ward drew the majority of the illustrations. W Masterson and A Hill formatted this Memoir and the Sheet Explanations. This volume was compiled by A R Farrant and edited by R J Thomas

Palaeozoic petroleum systems of the central North Sea/Mid North Sea High

This report synthesises the results of the 21CXRM Palaeozoic project to describe the Carboniferous and Devonian petroleum systems of the Central North Sea/Mid North Sea High area (Quadrants 25–44). Focusing on frontier areas to the north of the Southern North Sea gas fields and west of the Auk-Flora ridge, integration of a large volume of seismic, well, geophysical, organic geochemistry, maturity and reservoir property data at regional scale has established: Extensional to strike-slip Devonian and Carboniferous basins cutting across the Mid North Sea High on orientations strongly controlled by basement inheritance, granites and a complex Palaeozoic stress field. Varsican orogenic transpression and inversion was superimposed resulting in a variety of structural trapping styles and burial/uplift histories, and a complicated pre-Permian subcrop map. A widespread spatial and temporal extent of oil and gas mature source rock intervals within the Carboniferous succession particularly; o lower Carboniferous (Visean) coals and mudstones of the Scremerston Formation, dominantly fluvio-deltaic and lacustrine with some marine influence, dominantly gas prone. Gas mature in Quadrant 41 and central-southern Quadrants 42-44 and oil mature in the Forth Approaches and North Dogger Basin o lower-mid Carboniferous (Visean-Namurian) coals and mudstones of the Yoredale and Millstone Grit formations in fluvio-deltaic to marine cycles, gas prone with oil prone intervals. Gas mature in central Quadrant 41 and southern Quadrants 42-43, oil mature across northern Quadrants 41-44, Quadrant 36, 38 and 39. o Lower-mid Carboniferous (Visean-Namurian) mudstones and siltstones of the Cleveland Group, over 1 km thick, deposited in dominantly marine environments. Gas mature to overmature in southern Quadrants 41-44 and modelled as having generated oil and gas. Potentially widespread reservoir intervals of varying reservoir quality. Favourable intervals include the Upper Devonian sandstone of the Buchan Formation expecially where fractured, channels within the fluvio-deltaic lower-mid Carboniferous (Visean-Namurian) Scremerston, Yoredale and Millstone Grit formations, the laterally extensive, high net:gross Fell Sandstone Formation, and possibly turbidites or shoreface sands within marine mudstones/siltstones in southern Quadrants 41-44 (likely tight gas unless early hydrocarbon charged) Widespread opportunities for structural (fault/fold/dip) traps utilising a Silverpit mudstone, or Zechstein evaporite seal as in the Breagh Field. Intraformational Carboniferous seals are documented widely in onshore Carboniferous fields and in some offshore fields and should be further investigated, particularly in mudstone/siltstone-dominated basinal successions with modelled Carboniferous and recent hydrocarbon generation, along with possibilities for stratigraphic traps. Basin modelling predicts oil and gas generation at a variety of times (Carboniferous, Mesozoic and Cenozoic dependent on the well) from lower-mid Carbonferous (Visean-Namurian) strata in Quadrants 41-44. In the Forth Approaches, Quadrant 29/North Dogger basins and on the poorly constrained Devonian-Carboniferous Mid North Sea High, oil window maturity levels are modelled at selected wells in a largely gas-prone sequence, though basinwards gas maturity may be achieved. It is recommended that the contribution and volumetrics of relatively thin oil-prone intervals within the Carboniferous succession be further investigated

National geological screening : Central England region

This report is the published product of one of a series of studies covering England, Wales and Northern Ireland commissioned by Radioactive Waste Management (RWM) Ltd. The report provides geological information about the Central England region to underpin the process of national geological screening set out in the UK Government’s White Paper Implementing geological disposal: a framework for the long-term management of higher activity radioactive waste (DECC, 2014). The report describes geological features relevant to the safety requirements of a geological disposal facility (GDF) for radioactive waste emplaced onshore and up to 20 km offshore at depths between 200 and 1000 m from surface. It is written for a technical audience but is intended to inform RWM in its discussions with communities interested in finding out about the potential for their area to host a GDF

National geological screening : Eastern England region

This report is the published product of one of a series of studies covering England, Wales and Northern Ireland commissioned by Radioactive Waste Management (RWM) Ltd. The report provides geological information about the Eastern England region to underpin the process of national geological screening set out in the UK’s government White Paper Implementing geological disposal: a framework for the long-term management of higher activity radioactive waste (DECC, 2014). The report describes geological features relevant to the safety requirements of a geological disposal facility (GDF) for radioactive waste emplaced onshore and up to 20 km offshore at depths between 200 m and 1000 m from surface. It is written for a technical audience but is intended to inform RWM in its discussions with communities interested in finding out about the potential for their area to host a GDF

Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis

BACKGROUND: Dysregulation of the cell cycle is a hallmark of many cancers including ovarian cancer, a leading cause of gynaecologic cancer mortality worldwide.METHODS: We examined single nucleotide polymorphisms (SNPs) (n = 288) from 39 cell cycle regulation genes, including cyclins, cyclin-dependent kinases (CDKs) and CDK inhibitors, in a two-stage study. White, non-Hispanic cases (n = 829) and ovarian cancer-free controls (n = 941) were genotyped using an Illumina assay.RESULTS: Eleven variants in nine genes (ABL1, CCNB2, CDKN1A, CCND3, E2F2, CDK2, E2F3, CDC2, and CDK7) were associated with risk of ovarian cancer in at least one genetic model. Seven SNPs were then assessed in four additional studies with 1689 cases and 3398 controls. Association between risk of ovarian cancer and ABL1 rs2855192 found in the original population [odds ratio, ORBB vs AA 2.81 (1.29-6.09), P = 0.01] was also observed in a replication population, and the association remained suggestive in the combined analysis [ORBB vs AA 1.59 (1.08-2.34), P = 0.02]. No other SNP associations remained suggestive in the replication populations.CONCLUSION: ABL1 has been implicated in multiple processes including cell division, cell adhesion and cellular stress response. These results suggest that characterization of the function of genetic variation in this gene in other ovarian cancer populations is warranted. British Journal of Cancer (2009) 101, 1461-1468. doi: 10.1038/sj.bjc.6605284 www.bjcancer.com Published online 8 September 2009 (C) 2009 Cancer Research U