Managing, Controlling and Improving Quality

This book presents an organized approach to quality management, control, and improvement. Because quality problems usually are the outcome of uncontrolled or excessive variability, statistical tools and other analytical methods play an important role in solving these problems. However, these techniques need to be implemented within a management structure that will ensure success. This text focuses on both the management structure and the statistical and analytical tools. It organizes and presents this material according to many years of teaching, research, and professional practice across a wide range of business and industrial setting

Bloch's theory in periodic structures with Rashba's spin-orbit interaction

We consider a two-dimensional electron gas with Rashba's spin-orbit interaction and two in-plane potentials superimposed along directions perpendicular to each other. The first of these potentials is assumed to be a general periodic potential while the second one is totally arbitrary. A general form for Bloch's amplitude is found and an eigen-value problem for the band structure of the system is derived. We apply the general result to the two particular cases in which either the second potential represents a harmonic in-plane confinement or it is zero. We find that for a harmonic confinement regions of the Brillouin zone with high polarizations are associated with the ones of large group velocity.Comment: 6 pages, 5 figure

Tunable few electron quantum dots in InAs nanowires

Quantum dots realized in InAs are versatile systems to study the effect of spin-orbit interaction on the spin coherence, as well as the possibility to manipulate single spins using an electric field. We present transport measurements on quantum dots realized in InAs nanowires. Lithographically defined top-gates are used to locally deplete the nanowire and to form tunneling barriers. By using three gates, we can form either single quantum dots, or two quantum dots in series along the nanowire. Measurements of the stability diagrams for both cases show that this method is suitable for producing high quality quantum dots in InAs.Comment: 8 pages, 4 figure

A model of mentorship for students from historically underrepresented groups in STEM

Mentorship is critical to student academic success and persistence, especially for students from historically underrepresented (HU) groups. In a program designed to support the academic success of HU undergraduates in STEM who wish to pursue a PhD in those fields, students experience comprehensive support including financial aid, highly-engaged mentoring, dual faculty mentorship, professional development workshops, and summer research experiences. Scholars in this program, the Cal-Bridge program, consistently report that faculty mentorship is the most impactful feature. While mentorship was rated highly, preliminary evaluation indicated an early deficit in a sense of community among scholars. In response, faculty professional development and support for peer networking were implemented to expand and enhance the relationships that support scholar success. Here we present a promising multifaceted model of mentorship that can support the academic success of HU undergraduates.Comment: Submitted to Understanding Interventions. 23 pages. 4 figures. Comments welcome

Does Twitter User Activity Promote Gambling-Related Content?

Social media has provided gambling operators with access to millions of individuals and novel ways to promote gambling. Research has suggested that exposure to gambling advertisements on social media platforms is associated with increased gambling in individuals at-risk for problem gambling. These findings bring into question whether social media platforms are sensitive to differences in user account activity (e.g., tweets, likes, accounts visited) when displaying advertisements and gambling-related content. To assess for these differences, four Twitter accounts were created and assigned to send out tweets containing pro-wagering versus safe-wagering-related messages. Additionally, one of each account was assigned to interact with Twitter profiles associated with gambling operators or responsible gambling. Accounts were assessed daily for advertisement traffic and gambling-related content from January to March 2022. The study included three phases that implemented changes in privacy settings, websites visited, and gambling-related tweets observed. To assess for between-phase differences, Tau-U analyses were performed using R. No gambling advertisements were observed throughout the study. Nongambling advertisements remained constant across all accounts. Gambling-related content observed depended on assigned account activity. Accounts that interacted with gambling operators’ profiles were only displayed pro-wagering-related content. Conversely, accounts that interacted with responsible gambling profiles were only displayed safe-wagering-related content. Findings suggest that Twitter is sensitive to differences in account activity. Social media platforms’ ethical obligations have been a topic of concern. However, it seems that the type of gambling-related content displayed on Twitter largely depends on the user’s activity, thus, placing responsibility for what is displayed on the user

An uncharged amine in the transition state of the ribosornal peptidyl transfer reaction.

The ribosome has an active site comprised of RNA that catalyzes peptide bond formation. To understand how RNA promotes this reaction requires a detailed understanding of the chemical transition state. Here, we report the Bronsted coefficient of the a-amino nucleophile with a series of puromycin derivatives. Both 50S subunit- and 70S ribosome-catalyzed reactions displayed linear free-energy relationships with slopes close to zero under conditions where chemistry is rate limiting. These results indicate that, at the transition state, the nucleophile is neutral in the ribosome-catalyzed reaction, in contrast to the substantial positive charge reported for typical uncatalyzed aminolysis reactions. This suggests that the ribosomal transition state involves deprotonation to a degree commensurate with nitrogen-carbon bond formation. Such a transition state is significantly different from that of uncatalyzed aminolysis reactions in solution

Lower odds of remission among women with rheumatoid arthritis: A cohort study in the Swiss Clinical Quality Management cohort.

To compare the likelihood of achieving remission between men and women with rheumatoid arthritis (RA) after starting their first biologic or targeted synthetic disease-modifying anti-rheumatic drug (b/tsDMARD). This cohort study in the Swiss Clinical Quality Management in Rheumatic Diseases (SCQM) registry included RA patients starting their first b/tsDMARD (1997-31/04/2018). The odds of achieving remission at ≤12-months, defined by disease activity score 28-joints (DAS28) <2.6, were compared between men and women. Secondary analyses were adjusted for age and seropositivity, and we investigated potential mediators or factors that could explain the main findings. The study included 2839 (76.3%) women and 883 (23.7%) men with RA. Compared to women, men were older at diagnosis and b/tsDMARD start, but had shorter time from diagnosis to b/tsDMARD (3.4 versus 5.0 years, p<0.001), and they had lower DAS28 at b/tsDMARD start. Compared to women, men had 21% increased odds of achieving DAS28-remission, with odds ratio (OR) 1.21, 95% confidence interval (CI) 1.02-1.42. Adjusting for age and seropositivity yielded similar findings (adjusted OR 1.24, 95%CI 1.05-1.46). Analyses of potential mediators suggested that the observed effect may be explained by the shorter disease duration and lower DAS28 at treatment initiation in men versus women. Men started b/tsDMARD earlier than women, particularly regarding disease duration and disease activity (DAS28), and had higher odds of reaching remission. This highlights the importance of early initiation of second line treatments, and suggests to target an earlier stage of disease in women to match the benefits observed in men

An Uncharged Amine in the Transition State of the Ribosomal Peptidyl Transfer Reaction

The ribosome has an active site comprised of RNA that catalyzes peptide bond formation. To understand how RNA promotes this reaction requires a detailed understanding of the chemical transition state. Here, we report the Brønsted coefficient of the α-amino nucleophile with a series of puromycin derivatives. Both 50S subunit- and 70S ribosome-catalyzed reactions displayed linear free-energy relationships with slopes close to zero under conditions where chemistry is rate limiting. These results indicate that, at the transition state, the nucleophile is neutral in the ribosome-catalyzed reaction, in contrast to the substantial positive charge reported for typical uncatalyzed aminolysis reactions. This suggests that the ribosomal transition state involves deprotonation to a degree commensurate with nitrogen-carbon bond formation. Such a transition state is significantly different from that of uncatalyzed aminolysis reactions in solution

Transdiagnostic prevention and intervention efforts are needed to address executive dysfunction

Abstract: Executive functioning (EF) is a multi-faceted construct important to activities of daily living, emotion regulation, and higher-order thinking and is often impaired in individuals with gambling disorder and/or alcohol use disorders. Deficits in EF are associated with poor treatment engagement, psychiatric comorbidities, and relapse. The present study examined EF in college students (N = 832) aged 18-24 (M= 19.23, SD=1.37, 76.5% Women) in relation to gambling and hazardous drinking. The Barkley’s Deficits in Executive Functioning was used to assess for global EF and 5 facets of EF: Time Management, Organization/Problem Solving, Self-Restraint, Self-Motivation, and Emotion-Regulation. Bivariate correlation and ANOVA analyses were conducted. Approximately 3% of college students reported problem gambling and 20% reported engagement in hazardous drinking. Compared to individuals with non-problem drinking and non-problem gambling: (1) individuals with problem gambling had worse global EF, self-restraint, emotion regulation, and self-motivation, (2) individuals with hazardous drinking had worse Global EF, self-restraint, and emotion regulation and (3) individuals with both problem gambling and hazardous drinking had worse EF on self-restraint. Implications: Impairments in several domains of EF (e.g., inhibition/self-restraint, emotion regulation, and self-motivation) were endorsed at a significantly higher rate among problematic gamblers and hazardous drinkers. Results partially support the pathways model of gambling (Blaszcynski & Nower, 2002) and support transdiagnostic prevention and intervention efforts around emotion regulation, motivation, and impulsivity

Measurement Models Matter: How Retrospective Calendar Versus Global Reports Yield Different Estimates of Treatment Outcome

Abstract: Retrospective reports are less accurate than objective measures of behavior and must be interpreted with consideration of the amount of distortion and error introduced by this methodology. The Gambling-Timeline Followback (G-TLFB) method is the gold standard retrospective assessment tool that is designed to minimize such error by asking for a specific recall of precise gambling behavior day-by-day using recall aids as compared to a global summation over time (e.g., how many gambling days in last month, how much money gambled in the last month). It remains an empirical question whether this difference in measurement format, G-TLFB versus global reports, alters the estimates of gambling treatment efficacy. Eighteen studies were identified for inclusion in a meta-analysis to explore this question. A mixed-effects subgroup analysis indicated that the effect of treatment relative to nonactive control on gambling frequency at posttreatment was significantly lower for studies using the G-TLFB (g = -0.20) than studies using other assessments (g = -0.71). There was no significant difference in the effect of treatment relative to nonactive control on gambling intensity at posttreatment between studies using the G-TLFB (g = -0.22) and studies using other assessments (g = -0.38). Implications: The G-TLFB yields more conservative and likely more precise estimates of the effect of gambling treatment on gambling frequency but not intensity than other retrospective assessments. The use of global retrospective assessments to assess gambling frequency and intensity may overestimate effects of gambling treatment on gambling frequency