1,493 research outputs found
A decrease of calcitonin serum concentrations less than 50 percent 30 minutes after thyroid surgery suggests incomplete C-cell tumor tissue removal
The prognosis of medullary thyroid carcinoma (MTC) depends on the completeness of the first surgical treatment. To date, it is not possible to predict whether the tumor has been completely removed after surgery. The aim of this study was to evaluate the reliability of an intraoperative calcitonin monitoring as a predictor of the final outcome after surgery in patients with MTC
Liver nodular regenerative hyperplasia after bone marrow transplant.
We report an unusual liver disease which may occur after bone marrow transplantation, i.e. the collapse of hepatic lobuli followed by regenerative islets: the resulting clinical picture may mimic GvHD or a viral disease, but histology is diagnostic, showing nodular regeneration in the absence of inflammation or fibrosis
Post-transplant cerebral toxoplasmosis diagnosed by magnetic resonance imaging.
Cerebral toxoplasmosis is a rare late complication in allogeneic bone marrow transplanted patients. Neuroradiological findings may suggest the correct diagnosis. We report a patient in whom cerebral magnetic resonance imaging (MRI) showed a lesion characteristic of toxoplasmosis. Anti- toxoplasma treatment led to clinical and radiological improvement. MRI seems to be a valid tool for detection and follow-up of cerebral toxoplasmosis
Quality, integrity and utility of COVID-19 science: opportunities for public health researchers
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CD34+ enriched donor lymphocyte infusions in a case of pure red cell aplasia and late graft failure after major ABO-incompatible bone marrow transplantation
A variety of immunohematological complications may occur after ABO-incompatible BMT. We report a CML patient (blood group O) who received a BMT from an HLA-identical sibling (blood group AB). The transplant was followed by normal myeloid and megakaryocytic engraftment, but erythroblastopenia persisted for more than 200 days after BMT. By bone marrow culture studies, a complement-dependent serum inhibitor of hemopoiesis was detected, suggesting immunological inhibition of erythropoiesis. The patient was resistant to a number of treatments such as intravenous gamma-globulins, prednisolone and high-dose erythropoietin. Full engraftment with normal blood counts and marrow cellularity was achieved after two dose-escalating CD34+-enriched donor lymphocyte infusions (DLI). This experience suggests that CD34+-enriched DLI may be an effective treatment for patients with delayed engraftment or late graft failure due to major ABO-incompatibility
Pre-Production and Quality Assurance of the Mu2e Calorimeter Silicon Photomultipliers
The Mu2e electromagnetic calorimeter has to provide precise information on
energy, time and position for 100 MeV electrons. It is composed of 1348
un-doped CsI crystals, each coupled to two large area Silicon Photomultipliers
(SiPMs). A modular and custom SiPM layout consisting of a 32 array of
66 mm UV-extended monolithic SiPMs has been developed to fulfill
the Mu2e calorimeter requirements and a pre-production of 150 prototypes has
been procured by three international firms (Hamamatsu, SensL and Advansid). A
detailed quality assurance process has been carried out on this first batch of
photosensors: the breakdown voltage, the gain, the quenching time, the dark
current and the Photon Detection Efficiency (PDE) have been determined for each
monolithic cell of each SiPMs array. One sample for each vendor has been
exposed to a neutron fluency up to 8.5~~10 1 MeV (Si) eq.
n/cm and a linear increase of the dark current up to tens of mA has been
observed. Others 5 samples for each vendor have undergone an accelerated aging
in order to verify a Mean Time To Failure (MTTF) higher than 10
hours.Comment: NDIP 2017 - New Developments In Photodetection, 3-7 July 2017, Tours
(France
Central venous catheter insertion: a bedside procedure for haematological patients.
The present management of onco-haematologic patients
may require continuous infusion of cytotoxic
drugs, use of drugs or concentrated ion solutions
which are toxic for the endothelial wall of small vessels,
infusion of large amounts of antibiotics or antimycotics,
red blood cell and platelet transfusion,
and not rarely parenteral nutrition. Such a complex
therapy needs a vascular access by a central vein
catheter (CVC) insertion. Many types of CVC are
available at present: tunnelled Hickman or Hickmanlike
catheters, subcutaneous ports, tunnelled catheters
with Groshong valve, external untunnelled
catheters
Energy and time resolution for a LYSO matrix prototype of the Mu2e experiment
We have measured the performances of a LYSO crystal matrix prototype tested
with electron and photon beams in the energy range 60450 MeV. This study has
been carried out to determine the achievable energy and time resolutions for
the calorimeter of the Mu2e experiment.Comment: 2 pages, 3 figures, 13th Pisa Meeting on Advanced Detector
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