Integrated strategies to prevent intradialytic hypotension: research protocol of the DialHypot study, a prospective randomised clinical trial in hypotension-prone haemodialysis patients

INTRODUCTION: In patients on maintenance haemodialysis (HD), intradialytic hypotension (IDH) is a clinical problem that nephrologists and dialysis nurses face daily in their clinical routine. Despite the technological advances in the field of HD, the incidence of hypotensive events occurring during a standard dialytic treatment is still very high. Frequently recurring hypotensive episodes during HD sessions expose patients not only to severe immediate complications but also to a higher mortality risk in the medium term. Various strategies aimed at preventing IDH are currently available, but there is lack of conclusive data on more integrated approaches combining different interventions. METHODS AND ANALYSIS: This is a prospective, randomised, open-label, crossover trial (each subject will be used as his/her own control) that will be performed in two distinct phases, each of which is divided into several subphases. In the first phase, 27 HD sessions for each patient will be used, and will be aimed at the validation of a new ultrafiltration (UF) profile, designed with an ascending/descending shape, and a standard dialysate sodium concentration. In the second phase, 33 HD sessions for each patient will be used and will be aimed at evaluating the combination of different UF and sodium profiling strategies through individualised dialysate sodium concentration. ETHICS AND DISSEMINATION: The trial protocol has been reviewed and approved by the local Institutional Ethics Committee (Comitato Etico AVEN, prot. 43391 22.10.19). The results of the trial will be presented at local and international conferences and submitted for publication to a peer-reviewed journal. TRIAL REGISTRATION NUMBER: ClinicalTrials.gov Registry (NCT03949088)

Magnetoplasmonic design rules for active magneto-optics

Light polarization rotators and non-reciprocal optical isolators are essential building blocks in photonics technology. These macroscopic passive devices are commonly based on magneto-optical Faraday and Kerr polarization rotation. Magnetoplasmonics - the combination of magnetism and plasmonics - is a promising route to bring these devices to the nanoscale. We introduce design rules for highly tunable active magnetoplasmonic elements in which we can tailor the amplitude and sign of the Kerr response over a broad spectral range

Tell Tuqan and the Matkh Basin in a Regional Perspective. Thoughts an Questions Raised by the International Conference.

Riflessioni sui contenuti delle relazioni presentate dai partecipanti alla Conferenza Internazionale e relativi alle diverse fasi insediative in Siria, dal Bronzo Antico IV a l Periodo Persian/Ellenistico

Trends in Village Life : The Early Bronze Age Phases at Tell Tuqan

The chapter offers an overview of the recent excavations at Tell Tuqan in Inner Syria, focusing on the data related to the Early Bronze Age occupation at the site

Trends in Village Life. The Early Bronze Age Phases at Tell Tuqan.

Le fasi di vita durante il BA III-IV a Tell Tuqan

Middle Bronze II Fortress V at Tell Mardikh-Ebla, Syria: preliminary Analysis of Architectural Context and Archaeological Materials

L’articolo presenta i risultati degli scavi archeologici condotti nell’Area V dove è stato riportato alla luce un complesso fortificato composto di diversi quartieri denominato Forte Occidentale, nell’ambito della ripresa sistematica delle indagini sui rampart della città paleosiriana. In particolare viene analizzata la Fortezza V, un edificio rettangolare composto da tre coppie di ambienti più una sala di ingresso, posto al margine nord-occidentale del complesso. L’eccezionale stato di conservazione della struttura, con i depositi archeologici intatti del livello di distruzione corrispondente all’assedio della città alla fine del periodo paleosiriano, ha permesso di recuperare molti materiali in giacitura primaria, direttamente sui piani pavimentali, tra cui vasi delle tipologie caratteristiche del Bronzo Medio IIB, cretule, pesi, oggetti basaltici associati a installazioni. La tipologia dell’edificio viene definita e confrontata con analoghe strutture difensive siriane e palestinesi, identificando una peculiare struttura difensiva elaborata durante il Bronzo Medio

From Relative Chronology to Absolute Chronology: the Second Millennium BC in Syria-Palestine (Rome 29th November – 21st December 2001) (Contributi del Centro Linceo Interdisciplinare «Beniamino Segre» 117)

Atti del colloquio internazionale sulla cronologia del LevanteProceedings of the International Colloquium on the History of the Levan

Recent insights into sodium and potassium handling by the aldosterone-sensitive distal nephron: a review of the relevant physiology

In recent years, our understanding of the physiology of the aldosterone-sensitive distal nephron (ASDN) has greatly advanced thanks to the discovery of the complex with-no-lysine kinase (WNK) signaling and the molecular characterization of the epithelial sodium channel (ENaC). A series of studies, initially focused on rare tubulopathies such as Gordon and Liddle syndromes, eventually led to a partial elucidation of the so-called “aldosterone paradox”, the traditional explanation of the physiology of such disparate conditions such as hyperkalemia and low effective arterial blood volume. The physiology of the ASDN is herein illustrated in light of the novel acquisitions in an easy-to-understand fashion, with the aim of giving the practicing nephrologist a solid “first glance” into this exciting but challenging field. Focus is on ion channels and transporters, their regulation by key hormones such as aldosterone and angiotensin II, and dietary implications