1,454 research outputs found
Heat Transfer on a Flat Plate in Continuum to Rarefied Hypersonic Fows at Mach Numbers of 19.2 and 25.4
Surface heat transfer rates measured on flat plates in hypervelocity shock tunne
Heat transfer on a flat plate in helium at Mach numbers 67.3 and 87.6 and in hypersonic corner flow with air at Mach number of 19
Hypersonic heat transfer rates on flat plates in helium and in corner flow region with ai
Dietary Methionine Restriction Regulates Liver Protein Synthesis and Gene Expression Independently of Eukaryotic Initiation Factor 2 Phosphorylation in Mice
Background: The phosphorylation of eukaryotic initiation factor 2 (p-eIF2) during dietary amino acid insufficiency reduces protein synthesis and alters gene expression via the integrated stress response (ISR).Objective: We explored whether a Met-restricted (MR) diet activates the ISR to reduce body fat and regulate protein balance.Methods: Male and female mice aged 3-6 mo with either whole-body deletion of general control nonderepressible 2 (Gcn2) or liver-specific deletion of protein kinase R-like endoplasmic reticulum kinase (Perk) alongside wild-type or floxed control mice were fed an obesogenic diet sufficient in Met (0.86%) or an MR (0.12% Met) diet for ≤5 wk. Ala enrichment with deuterium was measured to calculate protein synthesis rates. The guanine nucleotide exchange factor activity of eIF2B was measured alongside p-eIF2 and hepatic mRNA expression levels at 2 d and 5 wk. Metabolic phenotyping was conducted at 4 wk, and body composition was measured throughout. Results were evaluated with the use of ANOVA (P < 0.05).Results: Feeding an MR diet for 2 d did not increase hepatic p-eIF2 or reduce eIF2B activity in wild-type or Gcn2-/- mice, yet many genes transcriptionally regulated by the ISR were altered in both strains in the same direction and amplitude. Feeding an MR diet for 5 wk increased p-eIF2 and reduced eIF2B activity in wild-type but not Gcn2-/- mice, yet ISR-regulated genes altered in both strains similarly. Furthermore, the MR diet reduced mixed and cytosolic but not mitochondrial protein synthesis in both the liver and skeletal muscle regardless of Gcn2 status. Despite the similarities between strains, the MR diet did not increase energy expenditure or reduce body fat in Gcn2-/- mice. Finally, feeding the MR diet to mice with Perk deleted in the liver increased hepatic p-eIF2 and altered body composition similar to floxed controls.Conclusions: Hepatic activation of the ISR resulting from an MR diet does not require p-eIF2. Gcn2 status influences body fat loss but not protein balance when Met is restricted
Emergence: Key physical issues for deeper philosophical inquiries
A sketch of three senses of emergence and a suggestive view on the emergence
of time and the direction of time is presented. After trying to identify which
issues philosophers interested in emergent phenomena in physics view as
important I make several observations pertaining to the concepts, methodology
and mechanisms required to understand emergence and describe a platform for its
investigation. I then identify some key physical issues which I feel need be
better appreciated by the philosophers in this pursuit. I end with some
comments on one of these issues, that of coarse-graining and persistent
structures.Comment: 16 pages. Invited Talk at the Heinz von Foerster Centenary
International Conference on Self-Organization and Emergence: Emergent Quantum
Mechanics (EmerQuM11). Nov. 10-13, 2011, Vienna, Austria. Proceedings to
appear in J. Phys. (Conf. Series
Emergence: Key physical issues for deeper philosophical inquiries
A sketch of three senses of emergence and a suggestive view on the emergence
of time and the direction of time is presented. After trying to identify which
issues philosophers interested in emergent phenomena in physics view as
important I make several observations pertaining to the concepts, methodology
and mechanisms required to understand emergence and describe a platform for its
investigation. I then identify some key physical issues which I feel need be
better appreciated by the philosophers in this pursuit. I end with some
comments on one of these issues, that of coarse-graining and persistent
structures.Comment: 16 pages. Invited Talk at the Heinz von Foerster Centenary
International Conference on Self-Organization and Emergence: Emergent Quantum
Mechanics (EmerQuM11). Nov. 10-13, 2011, Vienna, Austria. Proceedings to
appear in J. Phys. (Conf. Series
Ursinus College Alumni Journal, July 1957
Bachelor\u27s degrees awarded to 135 • Letters to the editor • Ursinus evaluated • Note from the Admissions Office • Commencement 1957 • Ursinus astronomers record celestial event • The faculty cornered • York County alumni meet • April election results • New York alumni honor H. Dean Steward \u2707 • H. Ober Hess \u2733 speaks at college • History Department advises saving of documents • \u27Id al-Jalus, Ta\u27izz, Yemen, 1953 • May Day festivities • Washington alumni meet • Seventeen annual prizes awarded at commencement • Ursinus Woman\u27s Club • Mrs. William U. Helfferich feted • 1957 track season • 1957 varsity baseball • 1957 varsity tennis • 1957 top athletes • Women\u27s basketball • Blazer award • Memorial trophy for Ken Walker • Tennis and badminton undefeated season • News about ourselves • Weddings • Births • Necrologyhttps://digitalcommons.ursinus.edu/alumnijournal/1059/thumbnail.jp
A Field Training Guide for Human Subjects Research Ethics
Maria Merritt and colleagues report on a Field Training Guide for Human Subjects Research Ethics that they have developed to help train field workers in ethics for research
Dual-Earner Family Policies at Work for Single-Parent Families
Family dynamics are changing and single-parent families are becoming more common across countries. In their flagship report “Progress of the World’s Women, 2019–2020,” UN Women (2019) demonstrated that, contrary to popular belief, couples with children do not constitute a majority of all families, but rather there are many different types of families. Single parenthood is considered a “new social risk” in poverty and inequality (Bonoli, 2013). Therefore, policy makers and legislators have designed targeted policy specifically for single parents, such as targeted child benefits to single parents. In addition, legislation and social policy have been designed and implemented specifically for single parents, such as child support and family law such as child custody and shared residence. This study takes a different approach, based on the universalist argument that without adequate social protection that benefits all families, those families that are more vulnerable are often hit the hardest. We focus on family policies, and specifically we examine whether and to what extent single parents benefit from the same family policies that are available to all families with children
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