Pre-mRNA splicing aberrations and cancer

Splicing requires the accurate recognition of exonic sequences from the surrounding thousands of nucleotides of intronic sequence and is achieved by the coordinate interplay of splicing regulatory elements in genes and the trans-acting RNA and protein molecules to which they bind. Infidelity in this process can have dramatic consequences for protein production, with an errors resulting in mRNA instability or the production of aberrant protein products. It is therefore not surprising that disruptions of splicing processes have been associated with a wide range of diseases, including cancer. This review looks at some of the mechanisms that regulate splicing and how disruption of such mechanisms can contribute to cancer susceptibility and progression

Going global, feeling small: an examination of managers' reactions to global restructuring in a multinational organisation

This paper is concerned with examining the reactions of managers to the process of global restructuring in a large, multinational food-processing company. Much extant research concerning globalisation has focused on the wider economic, political and social outcomes. Perhaps surprisingly, relatively little attention has been given to how globalisation is experienced inside organisations. This paper examines how country-level managers have been affected by the move to a new global structure in their organisation. We present evidence of these managers feeling disempowered by global reorganisation and of a largely negative impact on their feelings towards the organisation they work for

Preferred 'Learning Styles' in Students Studying Sports Related Programmes in Higher Education in the United Kingdom.

This article investigates the 'preferred learning styles' and their relationship with grades for students undertaking sports-related undergraduate programmes at a higher education institution in the UK. Preferred 'learning styles' in students in this discipline have been identified as auditory, kinaesthetic and group, although the vast majority of students are multimodal in their learning preferences. Only individual learning style preference was found to be positively related to higher grade category, and group learning style preference was negatively related to grade category. The research aims to highlight the importance of a constructive alignment between sports learning activities and the learning styles of sports students, in order to enhance progression towards established sports learning outcomes. An issue of significance for the practitioner would be rebalancing learning and teaching methods to take cognisance of particular preferred learning styles, while still seeking to ensure that all learning styles are supported