Age differences in brain activity during emotion processing: reflections of age-Related decline or increased emotion regulation?

Despite the fact that physical health and cognitive abilities decline with aging, the ability to regulate emotion remains stable and in some aspects improves across the adult life span. Older adults also show a positivity effect in their attention and memory, with diminished processing of negative stimuli relative to positive stimuli compared with younger adults. The current paper reviews functional magnetic resonance imaging studies investigating age-related differences in emotional processing and discusses how this evidence relates to two opposing theoretical accounts of older adults’ positivity effect. The aging-brain model [Cacioppo et al. in: Social Neuroscience: Toward Understanding the Underpinnings of the Social Mind. New York, Oxford University Press, 2011] proposes that older adults’ positivity effect is a consequence of age-related decline in the amygdala, whereas the cognitive control hypothesis [Kryla-Lighthall and Mather in: Handbook of Theories of Aging, ed 2. New York, Springer, 2009; Mather and Carstensen: Trends Cogn Sci 2005;9:496–502; Mather and Knight: Psychol Aging 2005;20:554–570] argues that the positivity effect is a result of older adults’ greater focus on regulating emotion. Based on evidence for structural and functional preservation of the amygdala in older adults and findings that older adults show greater prefrontal cortex activity than younger adults while engaging in emotion-processing tasks, we argue that the cognitive control hypothesis is a more likely explanation for older adults’ positivity effect than the aging-brain model

Feasibility study of intelligent autonomous determination of the bladder voiding need to treat bedwetting using ultrasound and smartphone ML techniques

Unsatisfactory cure rates for the treatment of nocturnal enuresis (NE), i.e. bed-wetting, have led to the need to explore alternative modalities. New treatment methods that focus on preventing enuretic episodes by means of a pre-void alerting system could improve outcomes for children with NE in many aspects. No such technology exists currently to monitor the bladder to alarm before bed-wetting. The aim of this study is to carry out the feasibility of building, refining and evaluating a new, safe, comfortable and non-invasive wearable autonomous intelligent electronic device to monitor the bladder using a single-element low-powered low-frequency ultrasound with the help of Machine Learning techniques and to treat NE by warning the patient at the pre-void stage, enhancing quality of life for these children starting from the first use. The sensitivity and specificity values are 0.89 and 0.93 respectively for determining imminent voiding need. The results indicate that customised imminent voiding need based on the expansion of the bladder can be determined by applying a single-element transducer on a bladder in intermittent manner. The acquired results can be improved further with a comfortable non-invasive device by adding several more features to the current features employed in this pilot study

Intention Seekers: Conspiracist Ideation and Biased Attributions of Intentionality

Conspiracist beliefs are widespread and potentially hazardous. A growing body of research suggests that cognitive biases may play a role in endorsement of conspiracy theories. The current research examines the novel hypothesis that individuals who are biased towards inferring intentional explanations for ambiguous actions are more likely to endorse conspiracy theories, which portray events as the exclusive product of intentional agency. Study 1 replicated a previously observed relationship between conspiracist ideation and individual differences in anthropomorphisation. Studies 2 and 3 report a relationship between conspiracism and inferences of intentionality for imagined ambiguous events. Additionally, Study 3 again found conspiracist ideation to be predicted by individual differences in anthropomorphism. Contrary to expectations, however, the relationship was not mediated by the intentionality bias. The findings are discussed in terms of a domain-general intentionality bias making conspiracy theories appear particularly plausible. Alternative explanations are suggested for the association between conspiracism and anthropomorphism

The intrinsic neural architecture of inhibitory control: The role of development and emotional experience

Inhibitory control is a key determinant of goal-directed behavior. Its susceptibility to reward implies that its variations may not only reflect cognitive ability, but also sensitivity to goal-relevant information. Since cognitive ability and motivational sensitivity vary as a function of age and mood, we hypothesized that their relevance for predicting individual differences in inhibition would similarly vary. Here, we tested this prediction with respect to the brain's intrinsic functional architecture. Specifically, we reasoned that age and affective functioning would both moderate the relationship between inhibition and resting state expression of the dynamic neural organization patterns linked to engaging in cognitive effort versus those involved in manipulating motivationally salient information. First, we used task fMRI data from the Human Connectome Project (N = 359 participants) to identify the brain organization patterns unique to effortful cognitive processing versus manipulation of motivationally relevant information. We then assessed the association between inhibitory control and relative expression of these two neural patterns in an independent resting state dataset from the Nathan Kline Institute-Rockland lifespan sample (N = 247). As hypothesized, the relation between inhibition and intrinsic functional brain architecture varied as a function of age and affective functioning. Among those with superior affective functioning, better inhibitory control in adolescence and early adulthood was associated with stronger resting state expression of the brain pattern that typified processing of motivationally salient information. The opposite effect emerged beyond the age of 49. Among individuals with poorer affective functioning, a significant link between inhibition and brain architecture emerged only before the age of 28. In this group, superior inhibition was associated with stronger resting state expression of the neural pattern that typified effortful cognitive processing. Our results thus imply that motivational relevance makes a unique contribution to superior cognitive functioning during earlier life stages. However, its relevance to higher-order mentation decreases with aging and increased prevalence of mood-related problems, which raises the possibility that patterns of neurobehavioral responsiveness to motivational salience may constitute sensitive markers of successful lifespan development

Hearts strangely warmed (and cooled): Emotional experience in religious and atheistic individuals

In light of neurophysiological evidence suggesting a link between hemispheric dominance and religious preference, three studies tested whether atheists and religious individuals process emotions differently. Suggestive of right-hemispheric dominance, individuals who identified with religion reported more intense positive emotions associated with a recalled love experience (Study 1), greater sadness in immediate response to reading a tragic news story (Study 2), and more vivid recall of the subjective details of either their most recent birthday or an existential crisis (Study 3). They also reported greater alexithymia compared to atheists. Overall, agnostic/no religion individuals averaged in between these two groups. The results suggest that, relative to atheists, religious individuals have more accessible yet undifferentiated emotions, which may perhaps serve as raw materials for religious experience

The role of dorsolateral prefrontal function in relationship commitment

Commitment is an important determinant of relationship stability. Previous studies demonstrated that relationship stability is influenced by several personality variables, one of which is conscientiousness. To account for the influence of conscientiousness on relationship stability, we propose a neurological model of commitment. The model assumes that conscientiousness and commitment are influenced by individual differences in anterior and mid-dorsolateral prefrontal (amDLPFC) functioning, and that conscientiousness is a partial mediator of the association between amDLPFC functioning and commitment. Results from two studies with dating couples are consistent with this model. Study 2 suggests that, relative to other conscientiousness facets, self-efficacy is a more likely mediator of the effect of amDLPFC functioning on commitment

Transcendent experiences motivate "escape" from the body via intimate partnerships

Three studies involving younger and older samples tested a model centered upon individual differences in one's personal history of “immutable self” (IS) experiences, typified by consciousness transcending the usual spatiotemporal bounds associated with embodiment, such that conscious existence no longer seems contingent upon the physical body. In Study 1, optical-acoustic stimulation evoked an IS-related experience that increased the sense of physical containment (i.e., feeling isolated within one's body, separate from the rest of the world) among some individuals. Studies 2 and 3 showed that the heightened sense of physical containment associated with a history of IS experiences predicted intensified motivation to maintain an intimate partnership, previously shown elsewhere to reduce the salience of the body. Key comparisons between elderly Parkinson's disease patients versus their spouses and healthy controls provided suggestive evidence that dopaminergic function may be a critical contributor to this motivational sequence

The infernal now: Linking temporal inefficacy to cognitive ability and social adjustment

In three studies with younger and older adults, we examined the correlates of temporal inefficacy (TI), that is, discontent with the uncontrollability of the passage of time experienced as linear. Among young adults, high versus low TI was related to greater subjective salience of the present, but guided focus on either conception or death eliminated this relationship. Among older adults, higher TI was inversely related both to the capacity to engage in mental time travel—as assessed by an autobiographical recall task, suggesting that the salience of the present associated with TI reflects chronic difficulty in accessing past and future—and to working memory capacity, illustrating the pivotal role of cognitive resources in effective coping among older adults. Reflecting the perceived lack of control inherent to TI, higher TI was linked to compensatory efforts to reassert personal control in other domains—specifically, a heightened tendency to personalize and overattribute meaning to random events, a greater expressed willingness to subordinate a spouse's well-being to one's own, and a callous, manipulative attitude toward other people in general. Finally, TI was inversely related to age, suggesting that maturation may include reconciling oneself to the existential limits imposed by linear time

Cognitive Resources, Valence, and Memory Retrieval of Emotional Events in Older Adults

In 2 studies with older adults, the authors investigated the effect of executive attention resources on the retrieval of emotional public events. Participants completed a battery of working memory tasks, as a measure of executive attention, and a battery of tasks assessing memory, as well as subjective experiences associated with the retrieval of remote public events. Participants also rated the valence of each public event story. The group-rated valence of the public event stories predicted retrieval and the quality of experiences associated with them, such that emotionally arousing events elicited the highest memory rates and the richest experiences. Furthermore, positive public events elicited the highest memory rates. Executive attention moderated only the relationship between event valence and how participants' associated memories are experienced at retrieval, such that superior executive attention resources predicted richer experiences associated with positive relative to neutral and negative stories. The current results extend previous findings on the effects of aging on emotion regulation, suggesting that cognitive control resources modulate subjective experiences associated with retrieved memories for remote real life events, but not memory retrieval itsel

Religion, negative emotions, and regulation

In broad terms, James’s postulations set the agenda for this chapter. That is, we will fi rst examine the evidence suggestive of a “sick-souled” neural profi le typifi ed by a predominance of negative emotionality that might predispose some individuals to seek out religion as a means of coping with such tendencies. More specifi cally, we will review neurophysiological research linking the same pattern of hemispheric functional dominance and neurotransmitter activity to both a predisposition towards spirituality/religiosity and a tendency to experience negative mood states and more global diffi culties in cognitive-affective regulation. With this as a backdrop, we will suggest that some individuals who possess such a “sick-souled” neural profi le may be inclined therefore to turn to religion as a means of coping with their negative affective states