Editorial: state of the art body composition profiling: advances in imaging modalities and patient outcomes

In the last years, body composition (BC) analysis has emerged as a ground-breaking tool that can provide helpful data about nutritional status, in addition to more conventional indicators, as albumin value and body mass index. Recent data disclosed that distinct patterns of BC are associated with different outcomes, in particular in oncologic patients. Hence, we proposed this research topic, on one side, to expand knowledge about the imaging techniques to evaluate BC assessment, ranging from the most conventional ones to the most advanced (including artificial intelligence-aided techniques); on the other, to assess the effects of BC on different outcome indicators, as post-operative or chemotherapy-related complications and survival. In our research topic, we published eight papers: 3 focused on liver diseases, 1 on pancreatic cancer, 1 on ovarian cancer, 1 on lung cancer, 1 on breast cancer and 1 on radiotherapy, thus highlighting the wide variety of fields in which the clinical role of BC is under evaluation

Fertility preservation in ovarian tumours

A considerable number of patients with a cancer diagnosis are of childbearing age and have not satisfied their desire for a family. Despite ovarian cancer (OC) usually occurring in older patients, 3%–14% are diagnosed at a fertile age with the overall 5-year survival rate being 91.2% in women ≤44 years of age when it is found at 1A–B stage. In this scenario, testing the safety and the efficacy of fertility sparing strategies in OC patients is very important overall in terms of quality of life. Unfortunately, the lack of randomised trials to validate conservative approaches does not guarantee the safety of fertility preservation strategies. However, evidence-based data from descriptive series suggest that in selected cases, the preservation of the uterus and at least one part of the ovary does not lead to a high risk of relapse. This conservative surgery helps to maintain organ function, giving patients of childbearing age the possibility to preserve their fertility. We hereby analysed the main evidence from the international literature on this topic in order to highlight the selected criteria for conservative management of OC patients, including healthy BRCA mutations carriers

Novel platinum agents and mesenchymal stromal cells for thoracic malignancies : state of the art and future perspectives

Introduction: Non-small cell lung cancer and malignant pleural mesothelioma represent two of the most intriguing and scrutinized thoracic malignancies, presenting interesting perspectives of experimental development and clinical applications. Areas covered: In advanced non-small cell lung cancer, molecular targeted therapy is the standard firstline treatment for patients with identified driver mutations; on the other hand, chemotherapy is the standard treatment for patients without EGFR mutations or ALK rearrangement or those with unknown mutation status. Once considered an ineffective therapy in pulmonary neoplasms, immunotherapy has been now established as one of the most promising therapeutic options. Mesenchymal stromal cells are able to migrate specifically toward solid neoplasms and their metastatic localizations when injected intravenously. This peculiar cancer tropism has opened up an emerging field to use them as vectors to deliver antineoplastic drugs for targeted therapies. Expert opinion: Molecular targeted therapy and immunotherapy are the new alternatives to standard chemotherapy. Mesenchymal stromal cells are a new promising tool in oncology and\u2014although not yet utilized in the clinical practice, we think they will represent another main tool for cancer therapy and will probably play a leading role in the field of nanovectors and molecular medicine

Analysis of the saltwater wedge in a coastal karst aquifer with a double conduit network, numerical simulations and sensitivity analysis

We investigate the long-distance salinity in a dual permeability coastal karst aquifer with a double conduit network using a three-dimensional variable-density groundwater flow and multispecies transport SEAWAT model. Sensitivity analyses were used to evaluate the impact of the parameters and boundary conditions on the modeling saltwater wedge in a karstic aquifer situated in the Cuban land territory, including hydraulic conductivity, vertical anisotropy and salinity concentration; both in the conduits network and the fractured medium. These analyses indicated that hydraulic conductivity of the fractured medium and salt concentration were the ones that have a stronger effect on saltwater intrusion in a karstic aquifer. We also show results of the three-dimensional numerical simulations on groundwater salinity for different scenarios with the variabilities of the important parameters and compare results with electric conductivity profiles measured in a well

Effect of NF-κB/Rel inhibition on spontaneous vs chemotherapy-induced apoptosis in AML and normal cord blood CD34+ cells

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Liver contrast enhanced ultrasound perfusion imaging in the evaluation of chronic hepatitis C fibrosis: preliminary results

We wanted to determine whether liver contrast-enhanced ultrasound (CEUS)–derived peak signal intensity (PSI) and peak signal intensity/time (PIT) predict liver fibrosis in chronic hepatitis C (CHC). Fortynine patients with CHC (METAVIR classification) and 10 control subjects were included in the study. After a bolus of 2.4 mL SonoVue (Bracco Imaging, Milan, Italy) solution was injected into a peripheral vein, the right lobe of the liver containing the right portal vein was scanned in a transverse section. Two-dimensional sonography was performed using the Philips iU22 ultrasound system (Philips Healthcare, Best, the Netherlands). A 1.0–5.0-MHz (C5-1) wideband convex transducer was used, applying the following settings in all cases. Regions of interest were manually drawn over the right liver lobe and over the portal vein (PV). Liver parenchyma PSI (LPpsi) and PIT (LPpit), portal vein PSI (PVpsi) and PIT (PVpit) were automatically calculated. dPSI was defined as the difference between PVpsi and LPpsi. A significant correlation was observed between PAPSI and fibrosis scores. When patients were stratified according to their LPpsi, a significant difference was achieved only between patients with fibrosis score 0–1 vs. 2–3 and 2 vs. 4. Statistically significant differences between all fibrosis scores, except 0 vs. 1 and 3 vs. 4 were observed when dPSI was used to stratify patients. Overall diagnostic accuracy of LPpsi and dPSI measurement for severe fibrosis by area under the receiving operator characteristic curve analysis was, respectively, 0.87 and 0.88.We suggest that liver CEUS perfusion could have the potential to be used as a complementary tool for the evaluation of liver fibrosis. However, further large-scale studies are required to accurately assess its accuracy in the evaluation of liver fibrosis