237 research outputs found

    Internships That Make A Difference: Two Campuses Continuous Internship Improvement Experience

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    Internships have been used by many academic programs to augment the student’s educational experience. We discuss two internship programs that have been continuously refined in recent years to provide the students with a structured learning experience. We present a model for enriching student experiences by integrating internship experiences with academic experiences

    Five Strategic Imperatives For Interdisciplinary Study In Mass Communications/Media Studies In The U.S. And U.K.

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    Interdisciplinary study can allow students to share ideas with scholars in allied fields and broaden their knowledge of global issues. Mass communication/media studies programs in the U.S. and U.K. can serve as models to lead students into successful learning through interdisciplinary study. This paper outlines five strategic imperatives for the study of mass communication/media studies in the U.S. and U.K. Curriculum improvements are suggested for helping students evolve and grow into leaders in the field

    Einführung in die grafische Beschreibungssprache UML : Version 2. [Gefördert durch: Bundesministerium für Arbeit und Soziales aus Mitteln des Ausgleichfonds Förderkennzeichen 01KM141108]

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    Diese UML Schulung ist speziell für Sehgeschädigte Personen konzipiert und legt deshalb genauso viel Fokus auf die visuellen Beschreibungen der einzelnen UML-Elemente wie auf die Bedeutungen dieser. Vorgestellt werden das Klassendiagramm, das Anwendungsfalldiagramm, das Aktivitätsdiagramm und das Zustandsdiagramm

    Einführung in die grafische Beschreibungssprache UML : Version 1. [Gefördert durch: Bundesministerium für Arbeit und Soziales aus Mitteln des Ausgleichfonds Förderkennzeichen 01KM141108]

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    Diese UML Schulung ist speziell für Sehgeschädigte Personen konzipiert und legt deshalb genauso viel Fokus auf die visuellen Beschreibungen der einzelnen UML-Elemente wie auf die Bedeutungen dieser. Vorgestellt werden das Klassendiagramm, das Anwendungsfalldiagramm, das Aktivitätsdiagramm und das Zustandsdiagramm

    Canonical Piecewise-Linear Representation of Curves in the Wave Digital Domain

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    Global, explicit representations of nonlinearities are desirable when implementing nonlinear Wave Digital (WD) structures, as they free us from the burden of managing look-up tables, performing data interpolation and/or using iterative solvers. In this paper we present a method that, starting from certain parameterized PieceWise-Linear (PWL) curves in the Kirchhoff domain, allows us to express them in the WD domain using a global and explicit representation. We will show how some curves (multi-valued functions in the Kirchhoff domain) can be represented as functions in canonical PWL form in the WD domain. In particular, we will present a procedure, which, in the most general case, also returns the conditions on the reference port resistance under which it is possible to find explicit mappings in the WD domain

    Noninvasive rapid detection of metabolic adaptation in activated human T lymphocytes by hyperpolarized <sup>13</sup>C magnetic resonance.

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    The metabolic shift induced in human CD4 &lt;sup&gt;+&lt;/sup&gt; T lymphocytes by stimulation is characterized by an upregulation of glycolysis, leading to an augmentation in lactate production. This adaptation has already been highlighted with various techniques and reported in several previous studies. We herein propose a method to rapidly and noninvasively detect the associated increase in flux from pyruvate to lactate catalyzed by lactate dehydrogenase using hyperpolarized &lt;sup&gt;13&lt;/sup&gt; C magnetic resonance, a technique which can be used for in vivo imaging. It was shown that the conversion of hyperpolarized &lt;sup&gt;13&lt;/sup&gt; C-pyruvate to &lt;sup&gt;13&lt;/sup&gt; C-lactate during the one-minute measurement increased by a mean factor of 3.6 in T cells stimulated for 5 days as compared to resting T cells. This method can be extended to other metabolic substrates and is therefore a powerful tool to noninvasively analyze T cell metabolism, possibly in vivo

    Searching for targets for the systemic therapy of mesothelioma

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    Increasing knowledge about the molecular characteristics of mesothelioma had led to the identification of novel potential targets for systemic therapy. This review elaborates on the rationale behind targeted approaches that have been and are undergoing exploration in mesothelioma and summarizes available clinical results and ongoing efforts to improve the systemic therapy of mesotheliom

    Acute Motor Axonal Neuropathy in a Patient with Metastatic Pancreatic Neuroendocrine Tumor Receiving Chemotherapy with Capecitabine and Temozolomide: A Case Report

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    We report a case of a 37- year old female patient with metastatic pancreatic neuroendocrine tumor that developed acute motor axonal neuropathy after receiving chemotherapy with capecitabine and temozolomide. She had repeatedly progressed after several surgical resections of her liver metastases, other hepatic directed procedures, several sessions of peptide receptor radionuclide therapy and two systemic treatment lines. When we started a third line therapy with capecitabine (1500 mg absolute twice daily, day 1-14) and temozolomide (360 mg absolute in two divided doses on day 1-5) in a 28 days long cycle, she unexpectedly developed a progressive weakness of the upper and lower limbs and dysphagia. The diagnosis of acute motor axonal neuropathy was confirmed by nerve conduction studies. The patient`s condition improved rapidly after chemotherapy was stopped and plasma exchange (nine sessions) as well as a maintenance therapy with intravenous immunoglobulins was started. She was almost asymptomatic seven months after onset of symptoms. This case describes a previously unreported association between acute motor axonal neuropathy and chemotherapy with capecitabine and temozolomide
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