Syntéza bis-cystinyl fragmentu hinge oblasti lidského IgG1 na PEG, využívající enzymaticky štěpitelnou spojku

Bis-cystinyl fragment of hinge region from the human IgG1, containing enzymatically cleavable linker, was prepared using PEG

Melectin analogues: The influence of dendrimerization on antimicrobial and hemolytic activity

Dimers and tetramers of MEP and MEP derivatives were synthesized on Fmoc-Lys(Fmoc)-Rink amide resin, the tetramer was obtained from the dimer C-terminally extended via Cys-Cys linkage. In general, the dendrimerization of MEP led to an increase of haemolytic activity but did not improve substantially its antimicrobial properties

Synthesis of the bis-cystinyl fragment 225-232/225'-232' of the human IgGl hinge region

Hinge peptide was prepared using soluble polyethylene glycol (PEG) as a carrier and Boc strategy. We analyzed the peptide by CD