Kandydoza jamy ustnej

The increase in prevalence of local and systemic candidiasis is related with global population aging, implementing invasive diagnostic and therapeutic methods, aggressive cancer treatment, organ and bone marrow transplants, and corticosteroid and immunosuppressive therapy. Clinical observations indicate that the patient’s general condition, age, diet and social setting affect the susceptibility to oral candidiasis.Starzenie się społeczeństw oraz powszechne wprowadzenie do lecznictwa inwazyjnych metod diagnostycznych i terapeutycznych, agresywnych metod leczenia nowotworów, transplantacji narządów i szpiku kostnego, leków immunosupresyjnych i kortykosteroidów spowodowało większy niż kiedykolwiek rozwój grzybic powierzchniowych i układowych. Z obserwacji klinicznych wynika, że o rozwoju grzybicy (kandydozy) jamy ustnej decyduje odporność organizmu, wiek, sposób odżywiania oraz warunki socjalne

Severity of work in opinions of rural women living in the Bieszczady region of south-eastern Poland

Objective The objective of the study was recognition of the opinions of rural women living in the Bieszczady region of south-eastern Poland, concerning their perception of the degree of severity of work. The study was conducted among the inhabitants of the Cisna commune. Material and Methods The basic research instrument was a questionnaire form containing 15 items. The study covered 101 women living in the Cisna commune in the Bieszczady. The self-reported degree of work load on a farm was analyzed among women who were occupationally active, and those who were not occupationally active. The effect of assistance from family members on the severity of work perceived by women was considered. Results The women in the study focused on agro-tourism, a few of them were engaged in agricultural work and the majority worked in household gardens. The study showed that occupationally active women work considerably longer, on average, and are the most loaded, compared to those not engaged in occupational activity. The mean daily time devoted to duties on a farm did not significantly differ between occupationally active and non-active women, and amounted to 380 and 320 minutes, respectively. The majority of women who were non-active occupationally evaluated their household chores as the highest work load. In turn, the women who undertook occupational activity assessed them as most burdensome, despite great help from their family. The body positions assumed while performing field work were: standing, standing-bent-over, and walking. The mean evaluations of work load while standing and standing-bent-over did not significantly differ, but affected the work load among women who, however, could not assess the severity of their work resulting from the body position assumed

Levels of renalase and advanced oxidation protein products with regard to catecholamines in haemodialysed patients

Introduction The main mediators of the sympathetic nervous system in the effectors part are catecholamines (CA). An increased sympathetic nerve activity observed in chronic kidney disease (CKD), is due to a raised level of CA in plasma. Renalase is a protein secreted by the kidneys, composed of 342 amino acids, which is able to metabolize the circulating CA and possibly play an important role in the regulation of sympathetic tone and blood pressure. Also, oxidative stress, defined as a disruption of the equilibrium between the generation of oxidants, is a crucial factor in the development of the inflammatory syndrome associated with CKD. The advanced oxidation protein products (AOPP) represent exquisite markers of phagocyte-derived oxidative stress. Objective The aim of the study was to investigate the concentration of renalase and explore the associations between AOPP with regards to CA in haemodialysis (HD) patients. Material and Methods The study was conducted among 50 residents of the municipality and neighbouring villages in the province of Lublin, central-eastern Poland. Results In the studied patients, it was found that an average concentration of renalase was 44.8 ± 6.5 μg/mL, whereas of AOPP plasma levels – 57.5 ± 21.5 μmol/L. The results demonstrated the correlation between levels of renalase and AOPP in the HD patients. Indeed, elevated levels of renalase and AOPP in HD may be due to the presence of uremic toxins in blood. The concentration of urea affects the plasma concentrations of AOPP and renalase causing a direct relationship between renalase and AOPP. However, there is no clear relationship between renalase and circulating catecholamines in HD patient

Levels of renalase and advanced oxidation protein products with regard to catecholamines in haemodialysed patients

Introduction The main mediators of the sympathetic nervous system in the effectors part are catecholamines (CA). An increased sympathetic nerve activity observed in chronic kidney disease (CKD), is due to a raised level of CA in plasma. Renalase is a protein secreted by the kidneys, composed of 342 amino acids, which is able to metabolize the circulating CA and possibly play an important role in the regulation of sympathetic tone and blood pressure. Also, oxidative stress, defined as a disruption of the equilibrium between the generation of oxidants, is a crucial factor in the development of the inflammatory syndrome associated with CKD. The advanced oxidation protein products (AOPP) represent exquisite markers of phagocyte-derived oxidative stress. Objective The aim of the study was to investigate the concentration of renalase and explore the associations between AOPP with regards to CA in haemodialysis (HD) patients. Material and Methods The study was conducted among 50 residents of the municipality and neighbouring villages in the province of Lublin, central-eastern Poland. Results In the studied patients, it was found that an average concentration of renalase was 44.8 ± 6.5 μg/mL, whereas of AOPP plasma levels – 57.5 ± 21.5 μmol/L. The results demonstrated the correlation between levels of renalase and AOPP in the HD patients. Indeed, elevated levels of renalase and AOPP in HD may be due to the presence of uremic toxins in blood. The concentration of urea affects the plasma concentrations of AOPP and renalase causing a direct relationship between renalase and AOPP. However, there is no clear relationship between renalase and circulating catecholamines in HD patient

Rak płaskonabłonkowy jamy ustnej i stany przedrakowe - przegląd piśmiennictwa

Wprowadzenie: Rak płaskonabłonkowy stanowi ponad 90% nowotworów złośliwych jamy ustnej, jest szóstym pod względem częstości występowania nowotworem złośliwym. Nowotworom jamy ustnej często towarzyszą poważne dolegliwości fizyczne, utrudniające podstawowe czynności życiowe (oddychanie, odżywianie i mowę), mogą także upośledzać wzrok, słuch, węch, smak i inne funkcje układu nerwowego. Cel pracy: Celem pracy jest przedstawienie charakterystyki klinicznej raka płaskonabłonkowego ze szczególnym uwzględnieniem stanów przednowotworowych oraz czynników ryzyka. Rak płaskonabłonkowy jamy ustnej jest nowotworem złośliwym występującym w obrębie twarzo-czaszki. Zazwyczaj występuje w wardze dolnej, ale może także występować w tylnej ścianie gardła, śliniankach, migdałkach, gardle i nosie. Występuje częściej u mężczyzn niż u kobiet, częściej po 40 roku życia. Skłonność do raka płaskonabłonkowego jamy ustnej (OSCC) ma związek przede wszystkim z czynnikiem ryzyka takim jak alkohol, tytoń, a także predyspozycje genetyczne. Inne czynniki to zaburzona zdolność metabolizowania karcynogenów i naprawy DNA. Podsumowanie: Wykrywanie patologicznych zmian na błonie śluzowej jamy ustnej wciąż sprawia lekarzom duże trudności, pomimo coraz doskonalszych metod diagnostycznych. Wczesne wykrycie zmian przednowotworowych i nowotworowych na błonie śluzowej jamy ustnej umożliwia ich bardziej skuteczne i mniej okaleczające leczeni

Relationship between microRNA-146a expression and plasma renalase levels in hemodialyzed patients.

microRNA (miRNA) belongs to the non-coding RNAs family responsible for the regulation of gene expression. Renalase is a protein composed of 342 amino acids, secreted by the kidneys and possibly plays an important role in the regulation of sympathetic tone and blood pressure. The aim of the present study was to investigate plasma renalase concentration, and explore the relationship between miRNA-146a-5p expression and plasma renalase levels in hemodialyzed patients.The study population comprised 55 subjects who succumbed to various cardiac events, 27 women and 28 men, aged 65-70 years. The total RNA including miRNA fraction was isolated using QiagenmiRNEasy Serum/Plasma kit according to the manufacturer's protocol. The isolated miRNAs were analyzed using a quantitative polymerase chain reaction (qRT-PCR) technique. The plasma renalase levels were measured using a commercial ELISA kit.In the group of patients with high levels of renalase, higher miRNA-146a expression was found, compared with those with low concentration of renalase. Patients with simultaneous low miRNA-146a expression and high level of renalase were confirmed to deliver a significantly longer survival time compared with other patients.miRNA-146a and plasma renalase levels were estimated as independent prognostic factors of hemodialyzed patients' survival time. Patients with low miRNA-146a expression demonstrated a significantly longer survival time in contrast to the patients with a high expression level of miRNA-146a. Moreover, a significantly longer survival time was found in patients with high renalase activity compared with patients with low activity of the enzyme

Raw Data Plos One.docx

Raw data used for the preparation of a manuscript entitled "Relationship between microRNA-146a expression and plasma renalase levels in hemodialyzed patients", which is published in the Plos One journal <br

Probability of overall survival change depending on miRNA-146a expression level in the studied group.

<p>Low miRNA-146a expression level is a favorable prognostic factor of patients’ survival compared with patients with high expression of this miRNA (OS—69 vs. 56 months; p = 0.430; HR = 1.728).</p

Baseline characteristics in long-term dialysis patients.

<p>Baseline characteristics in long-term dialysis patients.</p

Probability of overall survival change depending on simultaneous analysis of renalase concentration and miRNA-146a expression level in hemodialyzed patients.

<p>Patients with simultaneous high concentration of renalase and low miRNA-146a expression demonstrate significantly higher OS compared with other studied patients (OS—77 vs. 39 months; p = 0.018; HR = 2.01).</p