Implementation of Standards of Good Pharmacy Practice in the World: A Review

The aim of the study is to review the historical stages of development of the requirements of good pharmaceutical practice (GPP), generalization of the normative documents recommended by the International pharmaceutical company (MFP) for use in the world of pharmaceutical practice. Methods of generalization of the information material and system analysis were used in the study. Historical stages of the development of the concept of the GPP in the world and the role of the World Health Organization and the FIP in the process were analyzed. Researches of professional standards of pharmacy practice in developed countries reveal different approaches to the regulation of such activities, however, despite the applicable model standards are developed by the pharmaceutical associations and are used by regulatory bodies, business owners, and professionals to control the quality of pharmacy services that are provided to the population. The study indicates that the development of the GPP standards should be resolved at the level of public professional organizations as the national regulation of pharmacy practice in different countries varies significantly. Prospects of further scientific researches are aimed on using the results of the study while developing and implementing national standards of the GPP in the world

On the crossing relation in the presence of defects

The OPE of local operators in the presence of defect lines is considered both in the rational CFT and the $c>25$ Virasoro (Liouville) theory. The duality transformation of the 4-point function with inserted defect operators is explicitly computed. The two channels of the correlator reproduce the expectation values of the Wilson and 't Hooft operators, recently discussed in Liouville theory in relation to the AGT conjecture.Comment: TEX file with harvmac; v3: JHEP versio

Anomalous thickness dependence of the Hall effect in ultrathin Pb layers on Si(111)

The magnetoconductive properties of ultrathin Pb films deposited on Si(111) are measured and compared with density-functional electronic band-structure calculations on two-dimensional, free-standing, 1 to 8 monolayers thick Pb(111) slabs. A description with free-standing slabs is possible because it turned out that the Hall coefficient is independent of the substrate and of the crystalline order in the film. We show that the oscillations in sign of the Hall coefficient observed as a function of film thickness can be explained directly from the thickness dependent variations of the electronic bandstructure at the Fermi energy.Comment: 4 pages incl. 3 figures, RevTeX, to appear in Phys. Rev.

“Green” Synthesis of Sucrose Octaacetate and Characterization of Its Physicochemical Properties and Antimicrobial Activity

Sucrose octaacetate (octa-O-acetylsucrose) has been synthesized by esterification of sucrose with acetic anhydride using ultrasound-assisted irradiation. This sucrose ester is a white, water-insoluble substance with a bitter taste. The FT-IR and NMR spectra confirmed acetylation and revealed the hydrophobic incorporation in sucrose molecule. Furthermore, the foamability, foam stability, emulsification and antimicrobial properties of octa-O-acetylsucrose were evaluated. Foams and 50 % (oil/water) model emulsions were prepared with 2 % (w/w) octa-O-acetylsucrose. The obtained results demonstrate the formation of emulsions and foams with high stability (50–70 %). The antimicrobial activity of octa-O-acetylsucrose was evaluated against seventeen microorganisms (Gram-positive and Gram-negative bacteria, yeasts, and fungi). Octa-O-acetylsucrose inhibited the growth of fungi Penicillium sp., Rhizopus sp. and Fusarium moniliforme at 5 mg cm–3, and yeasts Candida albicans at 1 mg cm–3. Inhibition against Gram-positive and Gram-negative bacteria was not observed. The obtained results demonstrate the potential applications of octa-O-acetylsucrose as a foaming agent, oil-in-water emulsion stabilizer, and antifungal substance in pharmaceutical and cosmetic preparations. This work is licensed under a Creative Commons Attribution 4.0 International License

The Virtue of Defects in 4D Gauge Theories and 2D CFTs

We advance a correspondence between the topological defect operators in Liouville and Toda conformal field theories - which we construct - and loop operators and domain wall operators in four dimensional N=2 supersymmetric gauge theories on S^4. Our computation of the correlation functions in Liouville/Toda theory in the presence of topological defect operators, which are supported on curves on the Riemann surface, yields the exact answer for the partition function of four dimensional gauge theories in the presence of various walls and loop operators; results which we can quantitatively substantiate with an independent gauge theory analysis. As an interesting outcome of this work for two dimensional conformal field theories, we prove that topological defect operators and the Verlinde loop operators are different descriptions of the same operators.Comment: 59 pages, latex; v2 corrections to some formula

't Hooft Operators in Gauge Theory from Toda CFT

We construct loop operators in two dimensional Toda CFT and calculate with them the exact expectation value of certain supersymmetric 't Hooft and dyonic loop operators in four dimensional \Ncal=2 gauge theories with SU(N) gauge group. Explicit formulae for 't Hooft and dyonic operators in \Ncal=2^* and \Ncal=2 conformal SQCD with SU(N) gauge group are presented. We also briefly speculate on the Toda CFT realization of arbitrary loop operators in these gauge theories in terms of topological web operators in Toda CFT.Comment: 49 pages, LaTeX. Typos fixed, references adde

Dietary fat intake as a risk factor for the development of diabetes. Multinational, multicenter study of the Mediterranean Group for the Study of Diabetes (MGDS)

In the context of the Multinational MGSD Nutrition Study, three groups of subjects were studied: 204 subjects with recently diagnosed diabetes(RDM),42subjectswithundiagnoseddiabetes(UDM)(AmericanDiabetesAssociation criteria—fasting plasma glucose [FPG] 126 mg/dl), and 55 subjects with impaired fasting glucose(IFG)(FPG 110and126mg/dl).Eachgroupwascomparedwithacontrolgroupof nondiabetic subjects, matched one by one for center, sex, age, and BMI. Nutritional habits were evaluated by a dietary history method, validated against the 3-day diet diary. In RDM, the questionnaire referred to the nutritional habits before the diagnosis of diabetes. Demographic data were collected, and anthropometrical and biochemical measurements were taken. RESULTS— Compared with control subjects, RDM more frequently had a family history of diabetes(49.0vs.14.2%;P0.001),exercisedless(exerciseindex53.5vs.64.4;P0.01),and more frequently had sedentary professions (47.5 vs. 27.4%; P 0.001). Carbohydrates contributed less to their energy intake (53.5 vs. 55.1%; P 0.05), whereas total fat (30.2 0.5 vs. 27.8 0.5%; P 0.001) and animal fat (12.2 0.3 vs. 10.8 0.3%; P 0.01) contributed moreandtheplant-to-animalfatratiowaslower(1.50.1vs.1.80.1;P0.01).UDMmore frequentlyhadafamilyhistoryofdiabetes(38.1vs.19.0%;P0.05)andsedentaryprofessions (58.5vs.34.1%;P0.05),carbohydratescontributedlesstotheirenergyintake(47.61.7vs. 52.81.4%;P0.05),totalfat(34.71.5vs.30.41.2%;P0.05)andanimalfat(14.2 0.9 vs. 10.6 0.7%; P 0.05) contributed more, and the plant-to-animal fat ratio was lower (1.6 0.2 vs. 2.3 0.4; P 0.05). IFG differed only in the prevalence of family history of diabetes (32.7 vs. 16.4%; P 0.05). CONCLUSIONS— Our data support the view that increased animal fat intake is associated with the presence of diabetes

Bulk correlation functions in 2D quantum gravity

We compute bulk 3- and 4-point tachyon correlators in the 2d Liouville gravity with non-rational matter central charge c<1, following and comparing two approaches. The continuous CFT approach exploits the action on the tachyons of the ground ring generators deformed by Liouville and matter ``screening charges''. A by-product general formula for the matter 3-point OPE structure constants is derived. We also consider a ``diagonal'' CFT of 2D quantum gravity, in which the degenerate fields are restricted to the diagonal of the semi-infinite Kac table. The discrete formulation of the theory is a generalization of the ADE string theories, in which the target space is the semi-infinite chain of points.Comment: 14 pages, 2 figure

Boundary States of c=1 and 3/2 Rational Conformal Field Theories

We study the boundary states for the rational points in the moduli spaces of c=1 conformal and c=3/2 superconformal field theories, including the isolated Ginsparg points. We use the orbifold and simple-current techniques to relate the boundary states of different theories and to obtain symmetry-breaking, non-Cardy boundary states. We show some interesting examples of fractional and twisted branes on orbifold spaces.Comment: Latex, 46 pages, 1 figur

Rigidity and defect actions in Landau-Ginzburg models

Studying two-dimensional field theories in the presence of defect lines naturally gives rise to monoidal categories: their objects are the different (topological) defect conditions, their morphisms are junction fields, and their tensor product describes the fusion of defects. These categories should be equipped with a duality operation corresponding to reversing the orientation of the defect line, providing a rigid and pivotal structure. We make this structure explicit in topological Landau-Ginzburg models with potential x^d, where defects are described by matrix factorisations of x^d-y^d. The duality allows to compute an action of defects on bulk fields, which we compare to the corresponding N=2 conformal field theories. We find that the two actions differ by phases.Comment: 53 pages; v2: clarified exposition of pivotal structures, corrected proof of theorem 2.13, added remark 3.9; version to appear in CM