A Precision Measurement of Nuclear Muon Capture on 3He

The muon capture rate in the reaction mu- 3He -> nu + 3H has been measured at PSI using a modular high pressure ionization chamber. The rate corresponding to statistical hyperfine population of the mu-3He atom is (1496.0 +- 4.0) s^-1. This result confirms the PCAC prediction for the pseudoscalar form factors of the 3He-3H system and the nucleon.Comment: 13 pages, 6 PostScript figure

Precise Neutron Magnetic Form Factors

Precise data on the neutron magnetic form factor G_{mn} have been obtained with measurements of the ratio of cross sections of D(e,e'n) and D(e,e'p) up to momentum transfers of Q^2 = 0.9 (GeV/c)^2. Data with typical uncertainties of 1.5% are presented. These data allow for the first time to extract a precise value of the magnetic radius of the neutron.Comment: 10 pages, 2 figures, submitted to Physics Letters

A Universal Decline Law of Classical Novae

We calculate many different nova light curves for a variety of white dwarf masses and chemical compositions, with the assumption that free-free emission from optically thin ejecta dominates the continuum flux. We show that all these light curves are homologous and a universal law can be derived by introducing a ``time scaling factor.'' The template light curve for the universal law has a slope of the flux, F \propto t^{-1.75}, in the middle part (from ~2 to ~6 mag below the optical maximum), but it declines more steeply, F \propto t^{-3.5}, in the later part (from ~6 to ~10 mag). This break on the light curve is due to a quick decrease in the wind mass-loss rate. The nova evolutions are approximately scaled by the time of break. Once the time of break is observationally determined, we can derive the various timescales of novae such as the period of a UV burst phase, the duration of optically thick wind phase, and the turnoff date of hydrogen shell-burning. We have applied our template light curve model to the three well-observed novae, V1500 Cyg, V1668 Cyg, and V1974 Cyg. Our theoretical light curves show excellent agreement with the optical y and infrared J, H, K light curves. The WD mass is estimated, from the light curve fitting, to be 1.15 M_\sun for V1500 Cyg, 0.95 ~M_\sun for V1668 Cyg, and 0.95-1.05 M_\sun for V1974 Cyg.Comment: To appear in ApJS, vol.167, 23 pages including 24 figure

Varying constants, Gravitation and Cosmology

Fundamental constants are a cornerstone of our physical laws. Any constant varying in space and/or time would reflect the existence of an almost massless field that couples to matter. This will induce a violation of the universality of free fall. It is thus of utmost importance for our understanding of gravity and of the domain of validity of general relativity to test for their constancy. We thus detail the relations between the constants, the tests of the local position invariance and of the universality of free fall. We then review the main experimental and observational constraints that have been obtained from atomic clocks, the Oklo phenomenon, Solar system observations, meteorites dating, quasar absorption spectra, stellar physics, pulsar timing, the cosmic microwave background and big bang nucleosynthesis. At each step we describe the basics of each system, its dependence with respect to the constants, the known systematic effects and the most recent constraints that have been obtained. We then describe the main theoretical frameworks in which the low-energy constants may actually be varying and we focus on the unification mechanisms and the relations between the variation of different constants. To finish, we discuss the more speculative possibility of understanding their numerical values and the apparent fine-tuning that they confront us with.Comment: 145 pages, 10 figures, Review for Living Reviews in Relativit

Cancer Biomarker Discovery: The Entropic Hallmark

Background: It is a commonly accepted belief that cancer cells modify their transcriptional state during the progression of the disease. We propose that the progression of cancer cells towards malignant phenotypes can be efficiently tracked using high-throughput technologies that follow the gradual changes observed in the gene expression profiles by employing Shannon's mathematical theory of communication. Methods based on Information Theory can then quantify the divergence of cancer cells' transcriptional profiles from those of normally appearing cells of the originating tissues. The relevance of the proposed methods can be evaluated using microarray datasets available in the public domain but the method is in principle applicable to other high-throughput methods. Methodology/Principal Findings: Using melanoma and prostate cancer datasets we illustrate how it is possible to employ Shannon Entropy and the Jensen-Shannon divergence to trace the transcriptional changes progression of the disease. We establish how the variations of these two measures correlate with established biomarkers of cancer progression. The Information Theory measures allow us to identify novel biomarkers for both progressive and relatively more sudden transcriptional changes leading to malignant phenotypes. At the same time, the methodology was able to validate a large number of genes and processes that seem to be implicated in the progression of melanoma and prostate cancer. Conclusions/Significance: We thus present a quantitative guiding rule, a new unifying hallmark of cancer: the cancer cell's transcriptome changes lead to measurable observed transitions of Normalized Shannon Entropy values (as measured by high-throughput technologies). At the same time, tumor cells increment their divergence from the normal tissue profile increasing their disorder via creation of states that we might not directly measure. This unifying hallmark allows, via the the Jensen-Shannon divergence, to identify the arrow of time of the processes from the gene expression profiles, and helps to map the phenotypical and molecular hallmarks of specific cancer subtypes. The deep mathematical basis of the approach allows us to suggest that this principle is, hopefully, of general applicability for other diseases

Adaptive Optics Observation of QSOs Fields

We present preliminary results of AO imaging of quasars fields obtained with the CFHT adaptive optics system. The different issues that can be adressed by QSOs imaging are illustrated. 1 Introduction Studies of the quasar environment can really benefits from the use of adaptive optics. There are basically three scientific issues that can be addressed through QSOs fields imaging; ffl the nature of the QSO host galaxy in order to disentangle, for instance, the difference between radio--loud and radio--quiet objects, ffl the properties of the possible companions in order to assess the role that gravitational interaction may play, ffl the properties of the intervening galaxies that give rise to the absorption line systems. AO offers a spatial resolution that allows the detection of the host--galaxy and by concentrating the flux in the core of the image permits the detection of faint companions or intervening galaxies. Unfortunately, adaptive optics observations of quasars fields are qu..

Human coronavirus NL63, France

The human coronavirus NL63 (HCoV-NL63) was first identified in The Netherlands, and its circulation in France has not been investigated. We studied HCoV-NL63 infection in hospitalized children diagnosed with respiratory tract infections. From November 2002 to April 2003, we evaluated 300 respiratory specimens for HCoV-NL63. Of the 300 samples, 28 (9.3%) were positive for HCoV-NL63. The highest prevalence was found in February (18%). The main symptoms were fever (61%), rhinitis (39%), bronchiolitis (39%), digestive problems (33%), otitis (28%), pharyngitis (22%), and conjunctivitis (17%). A fragment of the spike protein gene was sequenced to determine the variety of circulating HCoV-NL63. Phylogenetic analysis indicated that strains with different genetic markers cocirculate in Franc