S-Net for multi-memory multicores

Copyright ACM, 2010. This is the author's version of the work. It is posted here by permission of ACM for your personal use. Not for redistribution. The definitive version was published in Proceedings of the 5th ACM SIGPLAN Workshop on Declarative Aspects of Multicore Programming: http://doi.acm.org/10.1145/1708046.1708054S-Net is a declarative coordination language and component technology aimed at modern multi-core/many-core architectures and systems-on-chip. It builds on the concept of stream processing to structure dynamically evolving networks of communicating asynchronous components. Components themselves are implemented using a conventional language suitable for the application domain. This two-level software architecture maintains a familiar sequential development environment for large parts of an application and offers a high-level declarative approach to component coordination. In this paper we present a conservative language extension for the placement of components and component networks in a multi-memory environment, i.e. architectures that associate individual compute cores or groups thereof with private memories. We describe a novel distributed runtime system layer that complements our existing multithreaded runtime system for shared memory multicores. Particular emphasis is put on efficient management of data communication. Last not least, we present preliminary experimental data

Investment Analysis of Alternative Dairy Systems under MILC

Three dairy systems, 120-cow grazing, 120-cow conventional, and 600-cow concentrated, were evaluated by internal rate of return (IRR) accounting for the Milk Income Loss Contract (MILC). With MILC, the grazing and conventional systems had higher IRRs. Without MILC, the 600-cow dairy had the highest IRR. Results were sensitive to assumptions.Concentrated feeding, conventional, grazing, internal rate of return, Livestock Production/Industries,

Kinetics and Inhibition Studies of the L205R Mutant of cAMP-Dependent Protein Kinase Involved in Cushing’s Syndrome

Overproduction of cortisol by the hypothalamus–pituitary–adrenal hormone system results in the clinical disorder known as Cushing\u27s syndrome. Genomics studies have identified a key mutation (L205R) in the α‐isoform of the catalytic subunit of cAMP‐dependent protein kinase (PKACα) in adrenal adenomas of patients with adrenocorticotropic hormone‐independent Cushing\u27s syndrome. Here, we conducted kinetics and inhibition studies on the L205R‐PKACα mutant. We have found that the L205R mutation affects the kinetics of both Kemptide and ATP as substrates, decreasing the catalytic efficiency (kcat/KM) for each substrate by 12‐fold and 4.5‐fold, respectively. We have also determined the IC50 and Ki for the peptide substrate‐competitive inhibitor PKI(5–24) and the ATP‐competitive inhibitor H89. The L205R mutation had no effect on the potency of H89, but causes a \u3e 250‐fold loss in potency for PKI(5–24). Collectively, these data provide insights for the development of L205R‐PKACα inhibitors as potential therapeutics

Aerodynamic design of the contoured wind-tunnel liner for the NASA supercritical, laminar-flow-control, swept-wing experiment

An overview is presented of the entire procedure developed for the aerodynamic design of the contoured wind tunnel liner for the NASA supercritical, laminar flow control (LFC), swept wing experiment. This numerical design procedure is based upon the simple idea of streamlining and incorporates several transonic and boundary layer analysis codes. The liner, presently installed in the Langley 8 Foot Transonic Pressure Tunnel, is about 54 ft long and extends from within the existing contraction cone, through the test section, and into the diffuser. LFC model testing has begun and preliminary results indicate that the liner is performing as intended. The liner design results presented in this paper, however, are examples of the calculated requirements and the hardware implementation of them

Parsec-scale radio morphology and variability of a changing-look AGN: the case of Mrk 590

We investigate the origin of the parsec-scale radio emission from the changing-look active galactic nucleus (AGN) of Mrk 590, and examine whether the radio power has faded concurrently with the dramatic decrease in accretion rates observed between the 1990s and the present. We detect a compact core at 1.6 GHz and 8.4 GHz using new Very Long Baseline Array observations, finding no significant extended, jet-like features down to $\sim$1 pc scales. The flat spectral index ($\alpha_{1.6}^{8.4} = 0.03$) and high brightness temperature ($T_{\rm b} \sim 10^{8}\,\rm K$) indicate self-absorbed synchrotron emission from the AGN. The radio to X-ray luminosity ratio of ${\rm log}(L_{\rm R}/L_{\rm X}) \sim -5$, similar to that in coronally active stars, suggests emission from magnetized coronal winds, although unresolved radio jets are also consistent with the data. Comparing new Karl G. Jansky Very Large Array measurements with archival and published radio flux densities, we find $46\%$, $34\%$, and (insignificantly) $13\%$ flux density decreases between the 1990s and the year 2015 at 1.4 GHz, 5 GHz and 8.4 GHz respectively. This trend, possibly due to the expansion and fading of internal shocks within the radio-emitting outflow after a recent outburst, is consistent with the decline of the optical-UV and X-ray luminosities over the same period. Such correlated variability demonstrates the AGN accretion-outflow connection, confirming that the changing-look behaviour in Mrk 590 originates from variable accretion rates rather than dust obscuration. The present radio and X-ray luminosity correlation, consistent with low/hard state accretion, suggests that the black hole may now be accreting in a radiatively inefficient mode.Comment: 14 pages, 5 tables, 5 figures, accepted for publication in MNRA

On the soft X-ray spectrum of cooling flows

Strong evidence for cooling flows has been found in low resolution X-ray imaging and spectra of many clusters of galaxies. However high resolution X-ray spectra of several clusters from the Reflection Grating Spectrometer (RGS) on XMM-Newton now show a soft X-ray spectrum inconsistent with a simple cooling flow. The main problem is a lack of the emission lines expected from gas cooling below 1--2 keV. Lines from gas at about 2--3 keV are observed, even in a high temperature cluster such as A 1835, indicating that gas is cooling down to about 2--3 keV, but is not found at lower temperatures. Here we discuss several solutions to the problem; heating, mixing, differential absorption and inhomogeneous metallicity. Continuous or sporadic heating creates further problems, including the targetting of the heat at the cooler gas and also the high total energy required. So far there is no clear observational evidence for widespread heating, or shocks, in cluster cores, except in radio lobes which occupy only part of the volume. The implied ages of cooling flows are short, at about 1 Gyr. Mixing. or absorption, of the cooling gas are other possibilities. Alternatively, if the metals in the intracluster medium are not uniformly spread but are clumped, then little line emission is expected from the gas cooling below 1 keV. The low metallicity part cools without line emission whereas the strengths of the soft X-ray lines from the metal-rich gas depend on the mass fraction of that gas and not on the abundance, since soft X-ray line emission dominates the cooling function below 2 keV.Comment: 5 pages, with 2 figures, submitted to MNRA

A Variational Approach for Minimizing Lennard-Jones Energies

A variational method for computing conformational properties of molecules with Lennard-Jones potentials for the monomer-monomer interactions is presented. The approach is tailored to deal with angular degrees of freedom, {\it rotors}, and consists in the iterative solution of a set of deterministic equations with annealing in temperature. The singular short-distance behaviour of the Lennard-Jones potential is adiabatically switched on in order to obtain stable convergence. As testbeds for the approach two distinct ensembles of molecules are used, characterized by a roughly dense-packed ore a more elongated ground state. For the latter, problems are generated from natural frequencies of occurrence of amino acids and phenomenologically determined potential parameters; they seem to represent less disorder than was previously assumed in synthetic protein studies. For the dense-packed problems in particular, the variational algorithm clearly outperforms a gradient descent method in terms of minimal energies. Although it cannot compete with a careful simulating annealing algorithm, the variational approach requires only a tiny fraction of the computer time. Issues and results when applying the method to polyelectrolytes at a finite temperature are also briefly discussed.Comment: 14 pages, uuencoded compressed postscript fil

Project apollo. ship-shore communications using radio satellite relay

Requirements for antennas, radio and terminal equipment aboard Apollo communication and tracking ships to communicate with land stations by satellite rela