Examining the Role of Agitation and Aggression in Perceived Caregiver Burden

Recent research efforts in the area of dementia have revealed that the affected patients are not the only people that are impacted by this disorder. There are hidden victims that, more often than not, go unnoticed. These people are the caregivers, often family members, of a dementia patient. More and more attention is being focused on caregiver burden because it has been found that caring for a dementia patient can lead to medical and psychological problems in the caregiver. The purpose of this study was to determine if a positive correlation exists between the caregivers perceived burden and the patient\u27s degree of agitation and aggression. Preliminary results do indicate a positive correlation between agitation and perceived caregiver burden. The results of this study will be important in helping the neuropsychologist develop appropriate intervention for the dementia patient and his/her caregiver

Blood leukocytes recapitulate diabetogenic peptide-MHC-II complexes displayed in the pancreatic islets

Assessing the self-peptides presented by susceptible major histocompatibility complex (MHC) molecules is crucial for evaluating the pathogenesis and therapeutics of tissue-specific autoimmune diseases. However, direct examination of such MHC-bound peptides displayed in the target organ remains largely impractical. Here, we demonstrate that the blood leukocytes from the nonobese diabetic (NOD) mice presented peptide epitopes to autoreactive CD4 T cells. These peptides were bound to the autoimmune class II MHC molecule (MHC-II) I-Ag7 and originated from insulin B-chain and C-peptide. The presentation required a glucose challenge, which stimulated the release of the insulin peptides from the pancreatic islets. The circulating leukocytes, especially the B cells, promptly captured and presented these peptides. Mass spectrometry analysis of the leukocyte MHC-II peptidome revealed a series of β cell-derived peptides, with identical sequences to those previously identified in the islet MHC-II peptidome. Thus, the blood leukocyte peptidome echoes that found in islets and serves to identify immunogenic peptides in an otherwise inaccessible tissue

Improving child survival through a district management strengthening and community empowerment intervention: early implementation experiences from Uganda.

BACKGROUND: The Community and District Empowerment for Scale-up (CODES) project pioneered the implementation of a comprehensive district management and community empowerment intervention in five districts in Uganda. In order to improve effective coverage and quality of child survival interventions CODES combines UNICEF tools designed to systematize priority setting, allocation of resources and problem solving with Community dialogues based on Citizen Report Cards and U-Reports used to engage and empower communities in monitoring health service provision and to demand for quality services. This paper presents early implementation experiences in five pilot districts and lessons learnt during the first 2 years of implementation. METHODS: This qualitative study was comprised of 38 in-depth interviews with members of the District Health Teams (DHTs) and two implementing partners. These were supplemented by observations during implementation and documents review. Thematic analysis was used to distill early implementation experiences and lessons learnt from the process. RESULTS: All five districts health teams with support from the implementing partners were able to adopt the UNICEF tools and to develop district health operational work plans that were evidence-based. Members of the DHTs described the approach introduced by the CODES project as a more systematic planning process and very much appreciated it. Districts were also able to implement some of the priority activities included in their work plans but limited financial resources and fiscal decision space constrained the implementation of some activities that were prioritized. Community dialogues based on Citizen Report Cards (CRC) increased community awareness of available health care services, their utilization and led to discussions on service delivery, barriers to service utilization and processes for improvement. Community dialogues were also instrumental in bringing together service users, providers and leaders to discuss problems and find solutions. The dialogues however are more likely to be sustainable if embedded in existing community structures and conducted by district based facilitators. U report as a community feedback mechanism registered a low response rate. CONCLUSION: The UNICEF tools were adopted at district level and generally well perceived by the DHTs. The limited resources and fiscal decision space however can hinder implementation of prioritized activities. Community dialogues based on CRCs can bring service providers and the community together but need to be embedded in existing community structures for sustainability

Precision Measurement of the Proton and Deuteron Spin Structure Functions g2 and Asymmetries A2

We have measured the spin structure functions g2p and g2d and the virtual photon asymmetries A2p and A2d over the kinematic range 0.02 < x < 0.8 and 0.7 < Q^2 < 20 GeV^2 by scattering 29.1 and 32.3 GeV longitudinally polarized electrons from transversely polarized NH3 and 6LiD targets. Our measured g2 approximately follows the twist-2 Wandzura-Wilczek calculation. The twist-3 reduced matrix elements d2p and d2n are less than two standard deviations from zero. The data are inconsistent with the Burkhardt-Cottingham sum rule if there is no pathological behavior as x->0. The Efremov-Leader-Teryaev integral is consistent with zero within our measured kinematic range. The absolute value of A2 is significantly smaller than the sqrt[R(1+A1)/2] limit.Comment: 12 pages, 4 figures, 2 table

Effect of Localized Vibration Using Massage Gun at 40hz and 50hz on Blood Flow

Data has shown that whole body vibration can positively affect blood flow, however, there are very few studies on the effect of localized therapeutic vibration on arterial blood flow. Occupational studies looking at localized vibration effects on skin blood flow normally include high frequency settings. In the last few years, massage guns have become popular, but they operate at lower frequencies. Currently, there is no data on the effects of localized vibration from massage guns on arterial blood flow. PURPOSE: To compare the effects of two different frequencies of localized vibration on blood flow in the popliteal artery. METHODS: 12 subjects participated in this study (8 males and 4 females). Mean age was 22.7±1.6 years; mean height was 181.1±11.8 cm; mean weight was 78.2±16.2 kg. Participants wore shorts to give access to the popliteal artery. Participants were hooked to ECG leads to control measurement of artery diameter and then laid on a treatment table in a prone position with a foam roller under their ankles. Once at resting heart rate, baseline blood flow readings were taken using ultrasound, which measured TA Mean and Volume Flow. The participants were then randomly given a 5-minute treatment of control with no vibration or vibration at 40hz or 50hz. Blood flow readings were taken immediately post-treatment and then every minute for 5 minutes after. RESULTS: A two-factor repeated measures analysis was performed. Each subject was measured under all levels of condition (Control 5 min, 40hz 5 min, and 50hz 5 min) and time (baseline, post, post1-5). TA Mean and Volume Flow for both 40hz and 50hz were significantly greater than control (p=0.0020 and p=0.0110 respectively). The effect of time was significant (

The chemical abundance of the very metal rich old Open Clusters NGC 6253 and NGC 6791

In the framework of a project aiming at deriving in a homogeneous way the properties (age, distance, reddening and detailed chemical abundances) of a large sample of old open clusters, we present here the metal abundance and the abundance ratios of light (C, N, O, Na, Mg, Al, Si, Ca, Ti) and heavier (Cr, Mn, Ni, Ba, Eu) elements in the galactic open clusters NGC 6253 and NGC 6791. We performed spectrum synthesis of selected lines on high resolution spectra of four red clump stars in NGC 6253, taken with the UVES and FEROS spectrographs. We also determined abundances of the same elements for four red clump stars in NGC 6791, observed with SARG, for which we had derived the atmospheric parameters and the iron, carbon and oxygen abundances in a previous paper (Gratton et al. 2006). The average metallicity of NGC 6253 is [Fe/H]=+0.46 (rms = 0.03 dex, systematic error = 0.08 dex), obtained by extensive spectral synthesis of Fe lines. This intermediate age cluster closely resembles the old open cluster NGC 6791, as far as the chemical composition is concerned. C, N, O do not show any significant abundance scatter; they are underabundant with respect to the solar values both in NGC 6253 and NGC 6791. We also find no evident star-to-star scatter in any of the elements measured in both clusters, with the possible exception of Na in NGC 6791. The two clusters show very similar abundances, except for Mg, overabundant in NGC 6791 and not in NGC 6253. Both have solar scaled alpha-elements abundances. We have compared our abundance ratios with literature values for disk giants and dwarfs and bulge giants, finding a general good agreement with the run of elemental ratios with [Fe/H] of disk objects.Comment: Accepted for publication on A&