75,992 research outputs found
Data communications and monitor for the Penn State University profiler network
The profiler network installed by the Department of Meteorology at Penn State University utilizes a microcomputer for network monitoring and control. The network consists of two VHF and one UHF wind profiling Doppler radars. Additional measurement systems added to the network include temperature and humidity profiling radiometers, sodar for boundary layer wind profiling and selected surface based baseline systems. Remote diagnostic capabilities were also implemented in the Penn State network. It is possible to remotely analyze many specific malfunctions of the transmitter or signal processor
Tertiary lymphoid organs in central nervous system autoimmunity
Multiple sclerosis (MS) is an autoimmune disease characterized by chronic inflammation in the central nervous system (CNS), which results in permanent neuronal damage and substantial disability in patients. Autoreactive T cells are important drivers of the disease; however, the efficacy of B cell depleting therapies uncovered an essential role for B cells in disease pathogenesis. They can contribute to inflammatory processes via presentation of autoantigen, secretion of pro-inflammatory cytokines, and production of pathogenic antibodies. Recently, B cell aggregates reminiscent of tertiary lymphoid organs (TLOs) were discovered in the meninges of MS patients, leading to the hypothesis that differentiation and maturation of autopathogenic B and T cells may partly occur inside the CNS. Since these structures were associated with a more severe disease course, it is extremely important to gain insight into the mechanism of induction, their precise function, and clinical significance. Mechanistic studies in patients are limited. However, a few studies in the MS animal model experimental autoimmune encephalomyelitis (EAE) recapitulate TLO formation in the CNS and provide new insight into CNS TLO features, formation, and function. This review summarizes what we know so far about CNS TLOs in MS and what we have learned about them from EAE models. It also highlights the areas that are in need of further experimental work, as we are just beginning to understand and evaluate the phenomenon of CNS TLOs
Simulating Organogenesis in COMSOL: Tissue Mechanics
During growth, tissue expands and deforms. Given its elastic properties,
stresses emerge in an expanding and deforming tissue. Cell rearrangements can
dissipate these stresses and numerous experiments confirm the viscoelastic
properties of tissues [1]-[4]. On long time scales, as characteristic for many
developmental processes, tissue is therefore typically represented as a liquid,
viscous material and is then described by the Stokes equation [5]-[7]. On short
time scales, however, tissues have mainly elastic properties. In discrete
cell-based tissue models, the elastic tissue properties are realized by springs
between cell vertices [8], [9]. In this article, we adopt a macroscale
perspective of tissue and consider it as homogeneous material. Therefore, we
may use the "Structural Mechanics" module in COMSOL Multiphysics in order to
model the viscoelastic behavior of tissue. Concretely, we consider two
examples: first, we aim at numerically reproducing published [10] analytical
results for the sea urchin blastula. Afterwards, we numerically solve a
continuum mechanics model for the compression and relaxation experiments
presented in [4]
New ways of being public: the experience of foundation degrees
This article explores the recent development of new spheres of public engagement within UK higher education through an analysis of the foundation degree qualification. These, according to the Higher Education Funding Council for England (HEFCE), were designed to equip students with the combination of technical skills, academic knowledge, and transferable skills increasingly being demanded by employers, and they have been identified as being at the forefront of educational agendas aimed at increasing employer engagement in the higher education (HE) sector. As such, they might be regarded as an expression of the 'increasing privatisation' of HE. However, this article argues that, on the contrary, they have enabled the development of new areas of public engagement relating to the design and delivery of courses as well as providing new opportunities for the pursuit of public policy goals such as widening participation. Such outcomes, it is argued, are the result of a number of factors that explain the 'publicness' of the qualification and that should be sustained to ensure the implementation of the 2006 Leitch Report in a manner that further develops public engagement
Relationship between antihypertensive medications and cognitive impairment: Part II. Review of Physiology and animal studies
Purpose of Review There is an established association between hypertension and increased risk of poor cognitive performance and dementia including Alzheimer’s disease; however, associations between antihypertensive medications (AHM) and dementia risk are less clear. An increased interest in AHM has resulted in expanding publications; however, none of the recent reviews provide comprehensive review. Our extensive review includes 24 mechanistic animal and human studies published over the last 5 years assessing relationship between AHM and cognitive function. Recent Findings All classes of AHM showed similar result patterns in animal studies. The mechanism by which AHM exert their effect was extensively studied by evaluating well-established pathways of AD disease process, including amyloid beta (Aβ), vascular, oxidative stress and inflammation pathways, but only few studies evaluated the blood pressure lowering effect on the AD disease process. Summary Methodological limitations of the studies prevent comprehensive conclusions prior to further work evaluating AHM in animals and larger human observational studies, and selecting those with promising results for future RCTs
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