Kissing right? On the consistency of the head-turning bias in kissing

The present study investigated the consistency of the head-turning bias in kissing. In particular we addressed what happens if a person who prefers to kiss with the head turned to the right kisses a person who prefers to kiss with the head turned to the left. To this end, participants (N=57) were required to kiss a life-sized doll's head rotated in different orientations that were either compatible or incompatible with the participants' head-turning preference. Additionally, participants handedness, footedness, and eye preference was assessed. Results showed that a higher percentage of participants preferred to kiss with their head turned to the right than to the left. In addition, the right-turners were more consistent in their kissing behaviour than left-turners. That is, with the doll's head rotated in an incompatible direction, right-turners were less likely to switch their head to their non-preferred side. Since no clear relationships between head-turning bias and the other lateral preferences (i.e., handedness, footedness, and eye preference) were discerned, the more consistent head-turning bias among right-turners could not be explained as deriving from a joint pattern of lateral preferences that is stronger among individuals with rightward as compared to individuals with leftward lateral preferences. © 2010 Psychology Press

High dietary fat consumption impairs axonal mitochondrial function in vivo

Peripheral neuropathy (PN) is the most common complication of prediabetes and diabetes. PN causes severe morbidity for Type 2 diabetes (T2D) and prediabetes patients, including limb pain followed by numbness resulting from peripheral nerve damage. PN in T2D and prediabetes is associated with dyslipidemia and elevated circulating lipids; however, the molecular mechanisms underlying PN development in prediabetes and T2D are unknown. Peripheral nerve sensory neurons rely on axonal mitochondria to provide energy for nerve impulse conduction under homeostatic conditions. Models of dyslipidemia in vitro demonstrate mitochondrial dysfunction in sensory neurons exposed to elevated levels of exogenous fatty acids. Herein, we evaluated the effect of dyslipidemia on mitochondrial function and dynamics in sensory axons of the saphenous nerve of a male high-fat diet (HFD)-fed murine model of prediabetes to identify mitochondrial alterations that correlate with PN pathogenesis in vivo. We found that the HFD decreased mitochondrial membrane potential (MMP) in axonal mitochondria and reduced the ability of sensory neurons to conduct at physiological frequencies. Unlike mitochondria in control axons, which dissipated their MMP in response to increased impulse frequency (from 1 to 50 Hz), HFD mitochondria dissipated less MMP in response to axonal energy demand, suggesting a lack of reserve capacity. The HFD also decreased sensory axonal Ca^{2+} levels and increased mitochondrial lengthening and expression of PGC1α, a master regulator of mitochondrial biogenesis. Together, these results suggest that mitochondrial dysfunction underlies an imbalance of axonal energy and Ca^{2+} levels and impairs impulse conduction within the saphenous nerve in prediabetic PN

Reactions of a Be-10 beam on proton and deuteron targets

The extraction of detailed nuclear structure information from transfer reactions requires reliable, well-normalized data as well as optical potentials and a theoretical framework demonstrated to work well in the relevant mass and beam energy ranges. It is rare that the theoretical ingredients can be tested well for exotic nuclei owing to the paucity of data. The halo nucleus Be-11 has been examined through the 10Be(d,p) reaction in inverse kinematics at equivalent deuteron energies of 12,15,18, and 21.4 MeV. Elastic scattering of Be-10 on protons was used to select optical potentials for the analysis of the transfer data. Additionally, data from the elastic and inelastic scattering of Be-10 on deuterons was used to fit optical potentials at the four measured energies. Transfers to the two bound states and the first resonance in Be-11 were analyzed using the Finite Range ADiabatic Wave Approximation (FR-ADWA). Consistent values of the spectroscopic factor of both the ground and first excited states were extracted from the four measurements, with average values of 0.71(5) and 0.62(4) respectively. The calculations for transfer to the first resonance were found to be sensitive to the size of the energy bin used and therefore could not be used to extract a spectroscopic factor.Comment: 16 Pages, 10 figure

ρN\rho N resonance dynamics in the proton nucleus reaction

The strong coupling of rho meson to the nucleon produces $s$ and $p$ wave rho meson nucleon $(\rho N)$ resonances. In a nucleus, the $\rho N$ resonance-hole polarization generates the optical potential or self-energy for the rho meson. The scattering of rho meson due to this potential provides valuable informations about the $\rho N$ resonance dynamics in a nucleus. To investigate it, we use this potential to calculate the mass distribution spectrum for the $\rho$ meson produced coherently in the proton nucleus reaction. The cross sections arising due to $s$ and $p$ wave $\rho N$ resonances have been presented. The coherent and incoherent contributions to the cross sections due to these resonances are compared. In addition, the calculated results due to non-relativistic and relativistic $\rho$ meson self-energy are illustrated.Comment: 13 pages, 6 figure

Odyssey

We present results obtained with the Odyssey simulation code. Odyssey is a 1, 2, and 3 dimensional AMR code using cartesian, cylindrical, and spherical coordinates. The results provide an interesting snapshot of Odyssey at this point in its development. Results include parallel performance and scaling, Eulerian hydrodynamics algorithm comparisons, ADI based diffusion solvers on hierarchical meshes, ECB treatment of material interfaces in diffusion solves

Broad-band gravitational-wave pulses from binary neutron stars in eccentric orbits

Maximum gravitational wave emission from binary stars in eccentric orbits occurs near the periastron passage. We show that for a stationary distribution of binary neutron stars in the Galaxy, several high-eccentricity systems with orbital periods in the range from tens of minutes to several days should exist that emit broad gravitational-wave pulses in the frequency range 1-100 mHz. The space interferometer LISA could register the pulsed signal from these system at a signal-to-noise ratio level $S/N>5\sqrt{5}$ in the frequency range $\sim 10^{-3}-10^{-1}$ Hz during one-year observational time. Some detection algorithms for such a signal are discussed.Comment: 17 pages, LATEX, 3 figures, Astronomy Letters, 2002, in press; typos corrected, refference adde

Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site.

Ubiquitin (Ub)-mediated proteolysis is a fundamental mechanism used by eukaryotic cells to maintain homeostasis and protein quality, and to control timing in biological processes. Two essential aspects of Ub regulation are conjugation through E1-E2-E3 enzymatic cascades and recognition by Ub-binding domains. An emerging theme in the Ub field is that these 2 properties are often amalgamated in conjugation enzymes. In addition to covalent thioester linkage to Ub's C terminus for Ub transfer reactions, conjugation enzymes often bind noncovalently and weakly to Ub at "exosites." However, identification of such sites is typically empirical and particularly challenging in large molecular machines. Here, studying the 1.2-MDa E3 ligase anaphase-promoting complex/cyclosome (APC/C), which controls cell division and many aspects of neurobiology, we discover a method for identifying unexpected Ub-binding sites. Using a panel of Ub variants (UbVs), we identify a protein-based inhibitor that blocks Ub ligation to APC/C substrates in vitro and ex vivo. Biochemistry, NMR, and cryo-electron microscopy (cryo-EM) structurally define the UbV interaction, explain its inhibitory activity through binding the surface on the APC2 subunit that recruits the E2 enzyme UBE2C, and ultimately reveal that this APC2 surface is also a Ub-binding exosite with preference for K48-linked chains. The results provide a tool for probing APC/C activity, have implications for the coordination of K48-linked Ub chain binding by APC/C with the multistep process of substrate polyubiquitylation, and demonstrate the power of UbV technology for identifying cryptic Ub-binding sites within large multiprotein complexes

Assessment and Student Learning – a fundamental relationship and the role of information and communication technologies

This paper reviews the role of assessment in student learning and its relationship with the use of information and communication technologies (ICT). There is ample evidence of technology-led innovations failing to achieve the transformations expected by educators. We draw upon existing research to illustrate the links between aspects of student learning, assessment practices and the use of ICT. Assessment influences not only what parts of a course get studied, but also how those parts are studied. While the adoption of ICT does not, in itself, change student behaviours, appropriately designed assessment that exploits the potential of ICT can change students’ approaches to learning. We argue that ICT can enable important learning outcomes to be achieved, but these must be underpinned by an assessment strategy that cues students to adopt a suitable approach to learning

e^+e^- Pair Production from γ\gamma A Reactions

We present a calculation of e^+e^- production in $\gamma A$ reactions at MAMI and TJNAF energies within a semi-classical BUU transport model. Dilepton invariant mass spectra for $\gamma$C, $\gamma$Ca and $\gamma$Pb are calculated at 0.8, 1.5 and 2.2 GeV. We focus on observable effects of medium modifications of the $\rho$ and $\omega$ mesons. The in-medium widths of these mesons are taken into account in a dynamical, consistent way. We discuss the transport theoretical treatment of broad resonances.Comment: 42 pages including 16 figure