Using microsatellites to obtain genetic structure data for Red-backed shrike (Lanius collurio) : a pilot study

Contains fulltext : 33090.pdf (publisher's version ) (Open Access

A Detailed Monte-Carlo Simulation for the Belle TOF System

We have developed a detailed Monte Carlo simulation program for the Belle TOF system. Based on GEANT simulation, it takes account of all physics processes in the TOF scintillation counters and readout electronics. The simulation reproduces very well the performance of the Belle TOF system, including the dE/dx response, the time walk effect, the time resolution, and the hit efficiency due to beam background. In this report, we will describe the Belle TOF simulation program in detail.Comment: To be submitted to NI

Alkaline phosphatase for treatment of sepsis-induced acute kidney injury: a prospective randomized double-blind placebo-controlled trial

Introduction: To evaluate whether alkaline phosphatase (AP) treatment improves renal function in sepsis-induced acute kidney injury (AKI), a prospective, double-blind, randomized, placebo-controlled study in critically ill patients with severe sepsis or septic shock with evidence of AKI was performed.Methods: Thirty-six adult patients with severe sepsis or septic shock according to Systemic Inflammatory Response Syndrome criteria and renal injury defined according to the AKI Network criteria were included. Dialysis intervention was standardized according to Acute Dialysis Quality Initiative consensus. Intravenous infusion of alkaline phosphatase (bolus injection of 67.5 U/kg body weight followed by continuous infusion of 132.5 U/kg/24 h for 48 hours, or placebo) starting within 48 hours of AKI onset and followed up to 28 days post-treatment. The primary outcome variable was progress in renal function variables (endogenous creatinine clearance, requirement and duration of renal replacement therapy, RRT) after 28 days. The secondary outcome variables included changes in circulating inflammatory mediators, urinary excretion of biomarkers of tubular injury, and safety.Results: There was a significant (P = 0.02) difference in favor of AP treatment relative to controls for the primary outcome variable. Individual renal parameters showed that endogenous creatinine clearance (baseline to Day 28) was significantly higher in the treated group relative to placebo (from 50 ± 27 to 108 ± 73 mL/minute (mean ± SEM) for the AP group; and from 40 ± 37 to 65 ± 30 mL/minute for placebo; P = 0.01). Reductions in RRT requirement and duration did not reach significance. The results in renal parameters were supported by significantly more pronounced reductions in the systemic markers C-reactive protein, Interleukin-6, LPS-binding protein and in the urinary excretion of Kidney Injury Molecule-1 and Interleukin-18 in AP-treated patients relative to placebo. The Drug Safety Monitoring Board did not raise any issues throughout the trial.Conclusions: The improvements in renal function suggest alkaline phosphatase is a promising new treatment for patients with severe sepsis or septic shock with AKI.Trial Registration: www.clinicaltrials.gov: NCTNCT00511186. © 2012 Pickkers et al.; licensee BioMed Central Ltd

Resistance to three thrips species in <i>Capsicum</i> spp. depends on site conditions and geographic regions

Capsicum species are commercially grown for pepper production. This crop suffers severely from thrips damage and the identification of natural sources of thrips resistance is essential for the development of resistant cultivars. It is unclear whether resistance to Frankliniella occidentalis as assessed in a specific environment holds under different conditions. Additionally, other thrips species may respond differently to the plant genotypes. Screening for robust and general resistance to thrips encompasses testing different Capsicum accessions under various conditions and with different thrips species. We screened 11 Capsicum accessions (C. annuum and C. chinense) for resistance to F. occidentalis at three different locations in the Netherlands. Next, the same 11 accessions were screened for resistance to Thrips palmi and Scirtothrips dorsalis at two locations in Asia. This resulted in a unique analysis of thrips resistance in Capsicum at five different locations around the world. Finally, all accessions were also screened for resistance to F. occidentalis in the Netherlands using a leaf disc choice assay, allowing direct comparison of whole plant and leaf disc assays. Resistance to F. occidentalis was only partially consistent among the three sites in the Netherlands. The most susceptible accessions were consistently susceptible, but which accession was the most resistant differed among sites. In Asia, one C. chinense accession was particularly resistant to S. dorsalis and T. palmi, but this was not the most resistant accession to F. occidentalis. Overall, resistance to F. occidentalis correlated with S. dorsalis but not with T. palmi resistance in the C. annuum accessions. Damage inflicted on leaf discs reflected damage on the whole plant level. Our study showed that identifying broad spectrum resistance to thrips in Capsicum may prove to be challenging. Breeding programmes should focus on developing cultivars suitable for growing in defined geographic regions with specific thrips species and abiotic conditions

On the Circular Orbit Approximation for Binary Compact Objects In General Relativity

One often-used approximation in the study of binary compact objects (i.e., black holes and neutron stars) in general relativity is the instantaneously circular orbit assumption. This approximation has been used extensively, from the calculation of innermost circular orbits to the construction of initial data for numerical relativity calculations. While this assumption is inconsistent with generic general relativistic astrophysical inspiral phenomena where the dissipative effects of gravitational radiation cause the separation of the compact objects to decrease in time, it is usually argued that the timescale of this dissipation is much longer than the orbital timescale so that the approximation of circular orbits is valid. Here, we quantitatively analyze this approximation using a post-Newtonian approach that includes terms up to order ({Gm/(rc^2)})^{9/2} for non-spinning particles. By calculating the evolution of equal mass black hole / black hole binary systems starting with circular orbit configurations and comparing them to the more astrophysically relevant quasicircular solutions, we show that a minimum initial separation corresponding to at least 6 (3.5) orbits before plunge is required in order to bound the detection event loss rate in gravitational wave detectors to < 5% (20%). In addition, we show that the detection event loss rate is > 95% for a range of initial separations that include all modern calculations of the innermost circular orbit (ICO).Comment: 10 pages, 12 figures, revtex

On Dark Matter Annihilation in the Local Group

Under the hypothesis of a Dark Matter composed by supersymmetric particles like neutralinos, we investigate the possibility that their annihilation in the haloes of nearby galaxies could produce detectable fluxes of $\gamma$-photons. Expected fluxes depend on several, poorly known quantities such as the density profiles of Dark Matter haloes, the existence and prominence of central density cusps and the presence of a population of sub-haloes. We find that, for all reasonable choices of Dark Matter halo models, the intensity of the $\gamma$-ray flux from some of the nearest extragalactic objects, like M31, is comparable or higher than the diffuse Galactic foreground. We show that next generation ground-based experiments could have the sensitivity to reveal such fluxes which could help us unveiling the nature of Dark Matter particles.Comment: 11 pages, 10 figures. Accepted for publication in Phys. Rev. D.; added a new paragraph on the detectability of Galactic sub-halos in our Galaxy; added a discussion on their model dependence. The relation of our results with the "CDM crisis" issue has also been adde

Coherent matter wave inertial sensors for precision measurements in space

We analyze the advantages of using ultra-cold coherent sources of atoms for matter-wave interferometry in space. We present a proof-of-principle experiment that is based on an analysis of the results previously published in [Richard et al., Phys. Rev. Lett., 91, 010405 (2003)] from which we extract the ratio h/m for 87Rb. This measurement shows that a limitation in accuracy arises due to atomic interactions within the Bose-Einstein condensate

Presence of an unusual 17α,21β(H)-bacteriohopanetetrol in Holocene sediments from Ace Lake (Antarctica)

Author Posting. © Elsevier B.V., 2008. This is the author's version of the work. It is posted here by permission of Elsevier B.V. for personal use, not for redistribution. The definitive version was published in Organic Geochemistry 39 (2008): 1029-1032, doi:10.1016/j.orggeochem.2008.01.008.Whilst investigating the intact biohopanoid (bacteriohopanepolyol, BHP) distribution in Holocene sediments from Ace Lake (Antarctica), we have identified the presence of ab- bacteriohopanetetrol in sediments aged up to 9400 years BP. To our knowledge, this is the first time that an intact polyfunctionalised BHP with the “geological” 17α,21β(H) configuration has been identified in a sediment. Previously, this structure has only been observed in species of the nitrogen fixing bacterium Frankia. Its presence here in the sedimentary environment has implications for the interpretation of hopanoid ββ/αβ ratios in the geological record.This work was supported by grants from the Australian Antarctic Science Advisory Committee (1166 to J.V.) and the Netherlands Organization for Scientific Research (NWO; 851.20.006 to J.S.S.D. and NWO-VENI grant 016.051.014 to M.J.L.C.) We gratefully acknowledge the NERC for funding (HMT) and The Science Research Infrastructure Fund (SRIF) from HEFCE for funding the purchase of the Thermo Electron Finnigan LCQ ion trap mass spectrometer

How are management fashions institutionalized? The role of institutional work

We explore how transitory management fashions become institutionalized. Based on the concepts of institutional entrepreneurship and institutional work, we postulate that fashionable management practices acquire permanence when they are anchored within fieldwide institutions. The building of such institutions requires various types of institutional work, including political work, technical work and cultural work. Based on a review of the empirical literature on various management fashions, we identify the actors engaging in these different types of works, and their skills. Our results suggest that the institutionalization effect is stronger if more types of institutional work are deployed and if the skill sets of the involved actors vary. We also argue that institutional construction in the case of management fashions is likely to take the form of decentralized `partaking' rather than being led by a single dominant institutional entrepreneur. We conclude with implications for the study of management fashions and the role of agency in institutionalization