Strontium isotope systematics of mixing groundwater and oil-field brine at Goose Lake in northeastern Montana, USA

Groundwater, surface water, and soil in the Goose Lake oil field in northeastern Montana have been affected by Cl- rich oil-field brines during long-term petroleum production. Ongoing multidisciplinary geochemical and geophysical studies have identified the degree and local extent of interaction between brine and groundwater. Fourteen samples representing groundwater, surface water, and brine were collected for Sr isotope analyses to evaluate the usefulness of 87Sr/86Sr in detecting small amounts of brine. Differences in Sr concentrations and 87Sr/86Sr are optimal at this site for the experiment. Strontium concentrations range from 0.13 to 36.9 mg/L, and corresponding 87Sr/86Sr values range from 0.71097 to 0.70828. The local brine has 168 mg/L Sr and a 87Sr/86Sr value of 0.70802. Mixing relationships are evident in the data set and illustrate the sensitivity of Sr in detecting small amounts of brine in groundwater. The location of data points on a Sr isotope-concentration plot is readily explained by an evaporation-mixing model. The model is supported by the variation in concentrations of most of the other solutes

Exact solutions of closed string theory

We review explicitly known exact $D=4$ solutions with Minkowski signature in closed bosonic string theory. Classical string solutions with space-time interpretation are represented by conformal sigma models. Two large (intersecting) classes of solutions are described by gauged WZW models and `chiral null models' (models with conserved chiral null current). The latter class includes plane-wave type backgrounds (admitting a covariantly constant null Killing vector) and backgrounds with two null Killing vectors (e.g., fundamental string solution). $D>4$ chiral null models describe some exact $D=4$ solutions with electromagnetic fields, for example, extreme electric black holes, charged fundamental strings and their generalisations. In addition, there exists a class of conformal models representing axially symmetric stationary magnetic flux tube backgrounds (including, in particular, the dilatonic Melvin solution). In contrast to spherically symmetric chiral null models for which the corresponding conformal field theory is not known explicitly, the magnetic flux tube models (together with some non-semisimple WZW models) are among the first examples of solvable unitary conformal string models with non-trivial $D=4$ curved space-time interpretation. For these models one is able to express the quantum hamiltonian in terms of free fields and to find explicitly the physical spectrum and string partition function.Comment: 50 pages, harvma

Isotopic tracers of gold deposition in Paleozoic limestones, Southern Nevada

Strontium isotopic analyses of barren and mineralized Paleozoic carbonate rocks show that hydrothermal fluids added radiogenic strontium ({sup 87}Sr) to the mineralized zones. At Bare Mountain, samples collected from mineralized areas have {delta}{sup 87}Sr{sub t} values ranging from +3.0 to +23.0, whereas unmineralized carbonate rocks have {delta}{sup 87}Sr, values of {minus}0.6 to +2.9. In other ranges, {delta}{sup 87}Sr, values of the unmineralized carbonate rocks are even lower and virtually indistinguishable from primary marine values. This correlation of elevated {delta}{sup 87}Sr{sub t} values with mineralized zones provides a useful technique for assessing the mineral potential of the Paleozoic basement beneath Yucca Mountain, and may find broader use in mineral exploration in the Basin and Range province as a whole

Enterprise Education Competitions: A Theoretically Flawed Intervention?

The demand for including enterprise in the education system, at all levels and for all pupils is now a global phenomenon. Within this context, the use of competitions and competitive learning activities is presented as a popular and effective vehicle for learning. The purpose of this chapter is to illustrate how a realist method of enquiry – which utilises theory as the unit of analysis – can shed new light on the assumed and unintended outcomes of enterprise education competitions. The case developed here is that there are inherent flaws in assuming that competitions will ‘work’ in the ways set out in policy and guidance. Some of the most prevalent stated outcomes – that competitions will motivate and reward young people, that they will enable the development of entrepreneurial skills, and that learners will be inspired by their peers – are challenged by theory from psychology and education. The issue at stake is that the expansion of enterprise education policy into primary and secondary education increases the likelihood that more learners will be sheep dipped in competitions, and competitive activities, without a clear recognition of the potential unintended effects. In this chapter, we employ a realist-informed approach to critically evaluate the theoretical basis that underpins the use of competitions and competitive learning activities in school-based enterprise education. We believe that our findings and subsequent recommendations will provide those who promote and practice the use of competitions with a richer, more sophisticated picture of the potential flaws within such activities.Peer reviewedFinal Published versio

Solution of the Kwiecinski evolution equations for unintegrated parton distributions using the Mellin transform

The Kwiecinski equations for the QCD evolution of the unintegrated parton distributions in the transverse-coordinate space (b) are analyzed with the help of the Mellin-transform method. The equations are solved numerically in the general case, as well as in a small-b expansion which converges fast for b Lambda_QCD sufficiently small. We also discuss the asymptotic limit of large bQ and show that the distributions generated by the evolution decrease with b according to a power law. Numerical results are presented for the pion distributions with a simple valence-like initial condition at the low scale, following from chiral large-N_c quark models. We use two models: the Spectral Quark Model and the Nambu--Jona-Lasinio model. Formal aspects of the equations, such as the analytic form of the b-dependent anomalous dimensions, their analytic structure, as well as the limits of unintegrated parton densities at x -> 0, x -> 1, and at large b, are discussed in detail. The effect of spreading of the transverse momentum with the increasing scale is confirmed, with growing asymptotically as Q^2 alpha(Q^2). Approximate formulas for for each parton species is given, which may be used in practical applications.Comment: 18 pages, 6 figures, RevTe

Commensurate Scale Relations in Quantum Chromodynamics

We use the BLM method to show that perturbatively-calculable observables in QCD can be related to each other without renormalization scale or scheme ambiguity. We define and study the commensurate scale relations. We show that the commensurate scales satisfy the renormalization group transitivity rule which ensures that predictions in PQCD are independent of the choice of an intermediate renormalization scheme. We generalize the BLM procedure to higher order. The application of this procedure to relate known physical observables in QCD gives surprisingly simple results. In particular, the annihilation ratio $R_{e^+e^-}$ and the Bjorken sum rule for polarized electroproduction are related through simple coefficients, which reinforces the idea of a hidden symmetry between these two observables.Comment: 35 pages (RevTeX), one PostScript figure included at the end. SLAC-PUB-6481, UMD Preprint #94-13

Potentiation of Carboplatin-Mediated DNA Damage by the Mdm2 Modulator Nutlin-3a in a Humanized Orthotopic Breast-to-Lung Metastatic Model

Triple-negative breast cancers (TNBC) are typically resistant to treatment, and strategies that build upon frontline therapy are needed. Targeting the murine double minute 2 (Mdm2) protein is an attractive approach, as Mdm2 levels are elevated in many therapy-refractive breast cancers. The Mdm2 protein-protein interaction inhibitor Nutlin-3a blocks the binding of Mdm2 to key signaling molecules such as p53 and p73α and can result in activation of cell death signaling pathways. In the present study, the therapeutic potential of carboplatin and Nutlin-3a to treat TNBC was investigated, as carboplatin is under evaluation in clinical trials for TNBC. In mutant p53 TMD231 TNBC cells, carboplatin and Nutlin-3a led to increased Mdm2 and was strongly synergistic in promoting cell death in vitro. Furthermore, sensitivity of TNBC cells to combination treatment was dependent on p73α. Following combination treatment, γH2AX increased and Mdm2 localized to a larger degree to chromatin compared with single-agent treatment, consistent with previous observations that Mdm2 binds to the Mre11/Rad50/Nbs1 complex associated with DNA and inhibits the DNA damage response. In vivo efficacy studies were conducted in the TMD231 orthotopic mammary fat pad model in NOD.Cg-Prkdc(scid)Il2rg(tm1Wjl)/SzJ (NSG) mice. Using an intermittent dosing schedule of combined carboplatin and Nutlin-3a, there was a significant reduction in primary tumor growth and lung metastases compared with vehicle and single-agent treatments. In addition, there was minimal toxicity to the bone marrow and normal tissues. These studies demonstrate that Mdm2 holds promise as a therapeutic target in combination with conventional therapy and may lead to new clinical therapies for TNBC

Increasing condom use in heterosexual men: development of a theory-based interactive digital intervention

Increasing condom use to prevent sexually transmitted infections is a key public health goal. Interventions are more likely to be effective if they are theory- and evidence-based. The Behaviour Change Wheel (BCW) provides a framework for intervention development. To provide an example of how the BCW was used to develop an intervention to increase condom use in heterosexual men (the MenSS website), the steps of the BCW intervention development process were followed, incorporating evidence from the research literature and views of experts and the target population. Capability (e.g. knowledge) and motivation (e.g. beliefs about pleasure) were identified as important targets of the intervention. We devised ways to address each intervention target, including selecting interactive features and behaviour change techniques. The BCW provides a useful framework for integrating sources of evidence to inform intervention content and deciding which influences on behaviour to target

Search for Baryon and Lepton Number Violating Decays of the τ\tau Lepton

We have searched for five decay modes of the tau lepton that simultaneously violate lepton and baryon number: tau -> anti-proton gamma, tau -> anti-proton pi0, tau -> anti-proton eta, tau -> anti-proton 2pi0, and tau -> anti-proton pi0eta. The data used in the search were collected with the CLEO II detector at the Cornell Electron Storage Ring (CESR). The integrated luminosity of the data sample is 4.7 fb^{-1}, corresponding to the production of 4.3 x 10^6 tau+tau- events. No evidence is found for any of the decays, resulting in much improved upper limits on the branching fractions for the two-body decays and first upper limits for the three-body decays.Comment: 8 pages, postscript file also available through http://w4.lns.cornell.edu/public/CLN