Evaluation of the vaginal flora in pregnant women receiving opioid maintenance therapy: a matched case-control study

Dataset supporting the conclusions of this article. (XLS 2634 kb

Impact of Maternal Body Build Characteristics on Newborn Size in Two Different European Populations

The association patterns between maternal anthropometric characteristics (stature, prepregnancy weight, prepregnancy body mass index, pregnancy weight gain) and newborn size (birth weight, length, head circumference) were tested with 10,240 single births taking place between 1985 and 1995 in Vienna, Austria, and 3,452 single births taking place between 1989 and 1995 in Westerstede-Ammerland (Friesland), northern Germany. Maternal size and newborn size differed highly significantly (p \u3c 0.001) between the two genetically and socioeconomically different population groups. Furthermore, the incidence of macrosomia among newborns (birth weight greater than 4000 g) was extraordinarily high (17.9%) in the Frisian group from northern Germany. In both populations taller and heavier women with a higher weight gain during pregnancy gave birth to heavier offspring. Nevertheless, the pregnancy weight gain, which indicates environmental conditions of the mother, had only a minor impact on newborn size compared with stature and prepregnancy weight, which reflect the maternal genetic potential to a higher degree

International Journal of Gynecology & Obstetrics / Value of increased nuchal translucency in the era of noninvasive prenatal testing with cellfree DNA

Objective To assess the value of increased nuchal translucency (NT ) at firsttrimester screening (FTS ) despite the superiority of noninvasive prenatal testing with cellfree DNA (cfDNA ) for the detection of fetal aneuploidies. Methods Retrospective analysis of all FTS data from 2005 to 2015 in our department. Only cases with increased NT and euploid karyotype were considered eligible for inclusion. Abnormal findings, diagnostic workup, and perinatal outcomes were assessed. Results Of 18 084 FTS results, 460 (2.5%) showed increased fetal NT , of which 242 (52.6%) underwent invasive karyotyping and 179 (74.0%) had an aneuploidy. Of the remaining 63 cases, 61 (96.8%) showed an additional sonographic finding at FTS and25 (78.1%) had a major anomaly at the second trimester organ scan. The outcome was termination of pregnancy in 28 (44.4%) cases, fetal demise in 5 (7.9%), delivery of an infant with malformation in 21 (33.3%), and delivery of a healthy infant in 7 (11.1%) cases. Conclusion All cases with increased NT would have been detected by cfDNA or by a major sonographic anomaly not later than the second trimester. Routine use of cfDNA , a basic sonogram, and an organ scan could reduce unnecessary workup and anxiety.(VLID)510238