Detection and Quantification of Atmospheric Carbonyl Compounds

Ambient air aldehyde analysis was performed in Schenectady, NY. The Technique, as prescribed by Kuntz et. Al. (7), entailed the trapping of the volatile aldehydes as their 2,4-dinitrophenylhydrazone derivatives in an acetonitrile solution. The derivatives were then separated on a reversed phase HPLC column and detexted by UV absorption at 254 and 360 nm., simultaneously. The air in Schenectady was found to contain formaedehyde and acetaldehyde at concentrations which ranged from .70 to 30.5 ppb and below that of detection to 1.6 ppb, respectively. Formaldehyde\u27s daily average in Schenectady was 7.6 ppb. The formaldehyde and acetaldehyde levels at Whiteface Mtn. ranged between .61-2.6 ppb and .33-.80 ppb, respectively. In addition, hourly sampling at both locations showed a diurnal variation in formaldehyde

Probabilistic Models for Exploring, Predicting, and Influencing Health Trajectories

Over the past decade, healthcare systems around the world have transitioned from paper to electronic health records. The majority of healthcare systems today now host large, on-premise clusters that support an institution-wide network of computers deployed at the point of care. A stream of transactions pass through this network each minute, recording information about what medications a patient is receiving, what procedures they have had, and the results of hundreds of physical examinations and laboratory tests. There is increasing pressure to leverage these repositories of data as a means to improve patient outcomes, drive down costs, or both. To date, however, there is no clear answer on how to best do this. In this thesis, we study two important problems that can help to accomplish these goals: disease subtyping and disease trajectory prediction. In disease subtyping, the goal is to better understand complex, heterogeneous diseases by discovering patient populations with similar symptoms and disease expression. As we discover and refine subtypes, we can integrate them into clinical practice to improve management and can use them to motivate new hypothesis-driven research into the genetic and molecular underpinnings of the disease. In disease trajectory prediction, our goal is to forecast how severe a patient's disease will become in the future. Tools to make accurate forecasts have clear implications for clinical decision support, but they can also improve our process for validating new therapies through trial enrichment. We identify several characteristics of EHR data that make it to difficult to do subtyping and disease trajectory prediction. The key contribution of this thesis is a collection of novel probabilistic models that address these challenges and make it possible to successfully solve the subtyping and disease trajectory prediction problems using EHR data

Robust Audio-Codebooks for Large-Scale Event Detection in Consumer Videos

Abstract In this paper we present our audio based system for detecting "events" within consumer videos (e.g. You Tube) and report our experiments on the TRECVID Multimedia Event Detection (MED) task and development data. Codebook or bag-of-words models have been widely used in text, visual and audio domains and form the state-of-the-art in MED tasks. The overall effectiveness of these models on such datasets depends critically on the choice of low-level features, clustering approach, sampling method, codebook size, weighting schemes and choice of classifier. In this work we empirically evaluate several approaches to model expressive and robust audio codebooks for the task of MED while ensuring compactness. First, we introduce the Large Scale Pooling Features (LSPF) and Stacked Cepstral Features for encoding local temporal information in audio codebooks. Second, we discuss several design decisions for generating and representing expressive audio codebooks and show how they scale to large datasets. Third, we apply text based techniques like Latent Dirichlet Allocation (LDA) to learn acoustictopics as a means of providing compact representation while maintaining performance. By aggregating these decisions into our model, we obtained 11% relative improvement over our baseline audio systems