Functionalization of graphene at the organic/water interface

A simple method for the deposition of noble metal (Pd, Au) nanoparticles on a free-standing chemical vapour deposited graphene (CVD GR) monolayer is reported. The method consists of assembling the high purity CVD GR, by transfer from poly (methyl methacrylate) (PMMA), at the organic/water interface. Metal deposition can then proceed using either spontaneous or electrochemically-controlled processes. The resultant graphene-based metal nanoclusters are characterized using atomic force and electron microscopy techniques, and the location of the nanostructures underneath the graphene layer is determined from the position and the intensity changes of the Raman bands (D, G, 2D). This novel process for decoration of a single-layer graphene sheet with metal nanoparticles using liquid/liquid interfaces opens an alternative and useful way to prepare low dimensional carbon-based nanocomposites and electrode materials

Athena: A New Code for Astrophysical MHD

A new code for astrophysical magnetohydrodynamics (MHD) is described. The code has been designed to be easily extensible for use with static and adaptive mesh refinement. It combines higher-order Godunov methods with the constrained transport (CT) technique to enforce the divergence-free constraint on the magnetic field. Discretization is based on cell-centered volume-averages for mass, momentum, and energy, and face-centered area-averages for the magnetic field. Novel features of the algorithm include (1) a consistent framework for computing the time- and edge-averaged electric fields used by CT to evolve the magnetic field from the time- and area-averaged Godunov fluxes, (2) the extension to MHD of spatial reconstruction schemes that involve a dimensionally-split time advance, and (3) the extension to MHD of two different dimensionally-unsplit integration methods. Implementation of the algorithm in both C and Fortran95 is detailed, including strategies for parallelization using domain decomposition. Results from a test suite which includes problems in one-, two-, and three-dimensions for both hydrodynamics and MHD are given, not only to demonstrate the fidelity of the algorithms, but also to enable comparisons to other methods. The source code is freely available for download on the web.Comment: 61 pages, 36 figures. accepted by ApJ

Structured States of Disordered Proteins from Genomic Sequences

Protein flexibility ranges from simple hinge movements to functional disorder. Around half of all human proteins contain apparently disordered regions with little 3D or functional information, and many of these proteins are associated with disease. Building on the evolutionary couplings approach previously successful in predicting 3D states of ordered proteins and RNA, we developed a method to predict the potential for ordered states for all apparently disordered proteins with sufficiently rich evolutionary information. The approach is highly accurate (79%) for residue interactions as tested in more than 60 known disordered regions captured in a bound or specific condition. Assessing the potential for structure of more than 1,000 apparently disordered regions of human proteins reveals a continuum of structural order with at least 50% with clear propensity for three-or two-dimensional states. Co-evolutionary constraints reveal hitherto unseen structures of functional importance in apparently disordered proteins. Keywords: Evolutionary couplings disorder; conformational flexibility; statistical physics; maximum entropy; EVfold; bioinformatics; computational biology; structure predictionNational Institutes of Health (U.S.) (Grant R01GM081871

Effects of processing conditions on texture and microstructure evolution in extra-low carbon steel during multi-pass asymmetric rolling

Multi-pass rolling was carried out on extra-low carbon steel at room temperature by imposing different ratios of asymmetry in the roll-diameters as well as by conventional mode. The aim of this study is to understand the effect of shear deformation due to the asymmetric conditions on the development of the rolling texture and the possibilities of propagating the shear deformation into the mid-thickness area of the sheet. The trends of the measured texture developments in both symmetric and asymmetric rolling indicate their dependence primarily on the stability and fraction of the Goss {110}<001> and the rotated cube {001}<111> orientations. The effects of asymmetry conditions were further examined on the microstructure evolution and were correlated to the increased orientation inhomogeneity and grain fragmentation. Both texture and microstructure development showed their dependence on the applied thickness reduction per pass, on the total thickness reduction of the sheet as well as on the degree of the imposed asymmetry. It was found that shear textures can be obtained by asymmetric rolling at conditions where all three parameters-asymmetry ratio, strain in one pass, and the total accumulated strain-are as large as possible

Closing the gaps in care of dyslipidemia: Revolutionizing management with digital health and innovative care models

Although great progress has been made in the diagnostic and treatment options for dyslipidemias, unawareness, underdiagnosis and undertreatment of these disorders remain a significant global health concern. Growth in digital applications and newer models of care provide novel tools to improve the management of chronic conditions such as dyslipidemia. In this review, we discuss the evolving landscape of lipid management in the 21st century, current treatment gaps and possible solutions through digital health and new models of care. Our discussion begins with the history and development of value-based care and the national establishment of quality metrics for various chronic conditions. These concepts on the level of healthcare policy not only inform reimbursements but also define the standard of care. Next, we consider the advances in atherosclerotic cardiovascular disease risk score calculators as well as evolving imaging modalities. The impact and growth of digital health, ranging from telehealth visits to online platforms and mobile applications, will also be explored. We then evaluate the ways in which machine learning and artificial intelligence-driven algorithms are being utilized to address gaps in lipid management. From an organizational perspective, we trace the redesign of medical practices to incorporate a multidisciplinary team model of care, recognizing that atherosclerotic cardiovascular disease risk is multifaceted and requires a comprehensive approach. Finally, we anticipate the future of dyslipidemia management, assessing the many ways in which atherosclerotic cardiovascular disease burden can be reduced on a population-wide scale

Softened magnetic excitations in the s = 3/2 distorted triangular antiferromagnet alpha-CaCr2O4

The spin dynamics and magnetic excitations of the slightly distorted triangular s = 3/2 system alpha-CaCr2O4 are investigated by means of Raman spectroscopy and electron spin resonance (ESR) to elucidate its peculiar magnetic properties. Two-magnon excitations in circular RL symmetry show a multi-maximum structure with a dominant spectral weight at low energies. The temperature dependence of the ESR linewidth is described by a critical broadening DeltaHpp(T) ~ (T - T_N)^{-p} with the exponent p = 0.30(3) - 0.38(5) for temperatures above T_N = 42.6 K. The exponent is much smaller than that of other s = 3/2 triangular lattices. This is ascribed to soft roton-like modes, indicative of the instability of a helical 120{\deg} phase. As an origin we discuss a complex spin topology formed by four inequivalent nearest neighbor and sizable next-nearest neighbor interactions.Comment: 7 pages, 4 figure

Friedewald-Estimated Versus Directly Measured Low-Density Lipoprotein Cholesterol and Treatment Implications

ObjectivesThe aim of this study was to compare Friedewald-estimated and directly measured low-density lipoprotein cholesterol (LDL-C) values.BackgroundLDL-C is routinely estimated by the Friedewald equation to guide treatment; however, compatibility with direct measurement has received relatively little scrutiny, especially at levels <70 mg/dl now targeted in high-risk patients.MethodsWe examined 1,340,614 U.S. adults who underwent lipid profiling by vertical spin density gradient ultracentrifugation (Atherotech, Birmingham, Alabama) from 2009 to 2011. Following standard practice, Friedewald LDL-C was not estimated if triglyceride levels were ≥400 mg/dl (n = 30,174), yielding 1,310,440 total patients and 191,333 patients with Friedewald LDL-C <70 mg/dl.ResultsPatients were 59 ± 15 years of age and 52% were women. Lipid distributions closely matched those in the National Health and Nutrition Examination Survey. A greater difference in the Friedewald-estimated versus directly measured LDL-C occurred at lower LDL-C and higher triglyceride levels. If the Friedewald-estimated LDL-C was <70 mg/dl, the median directly measured LDL-C was 9.0 mg/dl higher (5th to 95th percentiles, 1.8 to 15.4 mg/dl) when triglyceride levels were 150 to 199 mg/dl and 18.4 mg/dl higher (5th to 95th percentiles, 6.6 to 36.0 mg/dl) when triglyceride levels were 200 to 399 mg/dl. Of patients with a Friedewald-estimated LDL-C <70 mg/dl, 23% had a directly measured LDL-C ≥70 mg/dl (39% if triglyceride levels were concurrently 150 to 199 mg/dl; 59% if triglyceride levels were concurrently 200 to 399 mg/dl).ConclusionsThe Friedewald equation tends to underestimate LDL-C most when accuracy is most crucial. Especially if triglyceride levels are ≥150 mg/dl, Friedewald estimation commonly classifies LDL-C as <70 mg/dl despite directly measured levels ≥70 mg/dl, and therefore additional evaluation is warranted in high-risk patients

3D/2D Registration with Superabundant Vessel Reconstruction for Cardiac Resynchronization Therapy

<p>Miscellaneous classes: consistent/single studies of pregnancy associated pharmacokinetic changes (percent calculated as pregnant/nonpregnant values).</p