Higher order Jordan Osserman Pseudo-Riemannian manifolds

We study the higher order Jacobi operator in pseudo-Riemannian geometry. We exhibit a family of manifolds so that this operator has constant Jordan normal form on the Grassmannian of subspaces of signature (r,s) for certain values of (r,s). These pseudo-Riemannian manifolds are new and non-trivial examples of higher order Osserman manifolds

Fundamental constants and tests of theory in Rydberg states of hydrogen-like ions

Comparison of precision frequency measurements to quantum electrodynamics (QED) predictions for Rydberg states of hydrogen-like ions can yield information on values of fundamental constants and test theory. With the results of a calculation of a key QED contribution reported here, the uncertainty in the theory of the energy levels is reduced to a level where such a comparison can yield an improved value of the Rydberg constant.Comment: 4 pages, RevTe

Detecting genuine multipartite continuous-variable entanglement

We derive necessary conditions in terms of the variances of position and momentum linear combinations for all kinds of separability of a multi-party multi-mode continuous-variable state. Their violations can be sufficient for genuine multipartite entanglement, provided the combinations contain both conjugate variables of all modes. Hence a complete state determination, for example by detecting the entire correlation matrix of a Gaussian state, is not needed.Comment: 13 pages, 3 figure

Eccrine Porocarcinoma of the Skin is Rising in Incidence in the East of England

[No abstract available

Eccrine Porocarcinoma of the Skin is Rising in Incidence in the East of England

[No abstract available

TeV Neutrinos from Successful and Choked Gamma-Ray Bursts

Core collapse of massive stars resulting in a relativistic fireball jet which breaks through the stellar envelope is a widely discussed scenario for gamma-ray burst production. For very extended or slow rotating stars, the fireball may be unable to break through the envelope. Both penetrating and choked jets will produce, by photo-meson interactions of accelerated protons, a burst of neutrinos with energies in excess of 5 TeV while propagating in the envelope. The predicted flux, from both penetrating and chocked fireballs, should be easily detectable by planned cubic kilometer neutrino telescopes.Comment: Phys.Rev.Letters, in press, final version accepted 8/31/01 (orig. 3/17/01

Mimicking subsecond neurotransmitter dynamics with femtosecond laser stimulated nanosystems

Existing nanoscale chemical delivery systems target diseased cells over long, sustained periods of time, typically through one-time, destructive triggering. Future directions lie in the development of fast and robust techniques capable of reproducing the pulsatile chemical activity of living organisms, thereby allowing us to mimic biofunctionality. Here, we demonstrate that by applying programmed femtosecond laser pulses to robust, nanoscale liposome structures containing dopamine, we achieve sub-second, controlled release of dopamine – a key neurotransmitter of the central nervous system – thereby replicating its release profile in the brain. The fast delivery system provides a powerful new interface with neural circuits and to the larger range of biological functions that operate on this short timescale

Process Drivers, Inter-Model Spread, and the Path Forward: A Review of Amplified Arctic Warming

Arctic amplification (AA) is a coupled atmosphere-sea ice-ocean process. This understanding has evolved from the early concept of AA, as a consequence of snow-ice line progressions, through more than a century of research that has clarified the relevant processes and driving mechanisms of AA. The predictions made by early modeling studies, namely the fall/winter maximum, bottom-heavy structure, the prominence of surface albedo feedback, and the importance of stable stratification have withstood the scrutiny of multi-decadal observations and more complex models. Yet, the uncertainty in Arctic climate projections is larger than in any other region of the planet, making the assessment of high-impact, near-term regional changes difficult or impossible. Reducing this large spread in Arctic climate projections requires a quantitative process understanding. This manuscript aims to build such an understanding by synthesizing current knowledge of AA and to produce a set of recommendations to guide future research. It briefly reviews the history of AA science, summarizes observed Arctic changes, discusses modeling approaches and feedback diagnostics, and assesses the current understanding of the most relevant feedbacks to AA. These sections culminate in a conceptual model of the fundamental physical mechanisms causing AA and a collection of recommendations to accelerate progress towards reduced uncertainty in Arctic climate projections. Our conceptual model highlights the need to account for local feedback and remote process interactions within the context of the annual cycle to constrain projected AA. We recommend raising the priority of Arctic climate sensitivity research, improving the accuracy of Arctic surface energy budget observations, rethinking climate feedback definitions, coordinating new model experiments and intercomparisons, and further investigating the role of episodic variability in AA

Scar heterogeneity on cardiovascular magnetic resonance as a predictor of appropriate implantable cardioverter defibrillator therapy

Background: Despite the survival benefit of implantable-cardioverter-defibrillators (ICDs), the vast majority of patients receiving an ICD for primary prevention do not receive ICD therapy. We sought to assess the role of heterogeneous scar area (HSA) identified by late gadolinium enhancement cardiovascular magnetic resonance (LGE-CMR) in predicting appropriate ICD therapy for primary prevention of sudden cardiac death (SCD). Methods: From September 2003 to March 2011, all patients who underwent primary prevention ICD implantation and had a pre-implantation LGE-CMR were identified. Scar size was determined using thresholds of 4 and 6 standard deviations (SD) above remote normal myocardium; HSA was defined using 3 different criteria; as the region between 2 SD and 4 SD (HSA2-4SD), between 2SD and 6SD (HSA2-6SD), and between 4SD and 6SD (HSA4-6SD). The end-point was appropriate ICD therapy. Results: Out of 40 total patients followed for 25 ± 24 months, 7 had appropriate ICD therapy. Scar size measured by different thresholds was similar in ICD therapy and non-ICD therapy groups (P = NS for all). However, HSA2-4SD and HSA4-6SD were significantly larger in the ICD therapy group (P = 0.001 and P = 0.03, respectively). In multivariable model HSA2-4SD was the only significant independent predictor of ICD therapy (HR = 1.08, 95%CI: 1.00-1.16, P = 0.04). Kaplan-Meier analysis showed that patients with greater HSA2-4SD had a lower survival free of appropriate ICD therapy (P = 0.026). Conclusions: In primary prevention ICD implantation, LGE-CMR HSA identifies patients with appropriate ICD therapy. If confirmed in larger series, HSA can be used for risk stratification in primary prevention of SCD