Comprehensive needs analysis for the development of construction safety education tools in immersive reality

Construction industry remains one of the most hazardous industries to work in, despite numerous efforts by researchers and practitioners to improve levels of Health & Safety (H&S) and reduce the number of accidents which occur on the construction sites. A potential method to reduce the number accidents is to educate construction workers in hazard identification and to raise their awareness of the risks they face at the construction site through the use of emerging technologies such as Virtual Reality (VR) and Augmented Reality (AR). This paper presents the first intellectual output of an Erasmus+ project titled Construction Safety with Education and Training using Immersive Reality (CSETIR), whose goal is to examine and apply such VR and AR tools to improve the levels of H&S. Through the literature review and discussions with relevant stakeholders, most appropriate training methods were identified for the development of safety educational tools in the following project phases. VR and AR technologies have the potential to train construction workers in H&S, especially those who have little experience in construction safety, workers with literacy limitations and workers that do not speak the local language. Visual training tools, especially immersive ones, also provide better retention of acquired knowledge and skills. An immersive reality safety education tool, therefore, has the potential to increase the levels of construction H&S and to reduce the number of accidents at construction sites

20-HETE Mediates Ozone-Induced, Neutrophil-Independent Airway Hyper-Responsiveness in Mice

Background Ozone, a pollutant known to induce airway hyper-responsiveness (AHR), increases morbidity and mortality in patients with obstructive airway diseases and asthma. We postulate oxidized lipids mediate in vivo ozone-induced AHR in murine airways.Methodology/Principal Findings Male BALB/c mice were exposed to ozone (3 or 6 ppm) or filtered air (controls) for 2 h. Precision cut lung slices (PCLS; 250 µm thickness) containing an intrapulmonary airway (∼0.01 mm$^2$ lumen area) were prepared immediately after exposure or 16 h later. After 24 h, airways were contracted to carbachol (CCh). Log EC$_{50}$ and E$_{\text{max}}$ values were then calculated by measuring the airway lumen area with respect to baseline. In parallel studies, dexamethasone (2.5 mg/kg), or 1-aminobenzotriazol (ABT) (50 mg/kg) were given intraperitoneal injection to naïve mice 18 h prior to ozone exposure. Indomethacin (10 mg/kg) was administered 2 h prior. Cell counts, cytokine levels and liquid chromatography-mass spectrometry (LC-MS) for lipid analysis were assessed in bronchoalveolar lavage (BAL) fluid from ozone exposed and control mice. Ozone acutely induced AHR to CCh. Dexamethasone or indomethacin had little effect on the ozone-induced AHR; while, ABT, a cytochrome P450 inhibitor, markedly attenuated airway sensitivity. BAL fluid from ozone exposed animals, which did not contain an increase in neutrophils or interleukin (IL)-6 levels, increased airway sensitivity following in vitro incubation with a naïve PCLS. In parallel, significant increases in oxidized lipids were also identified using LC-MS with increases of 20-HETE that were decreased following ABT treatment.Conclusions/Significance These data show that ozone acutely induces AHR to CCh independent of inflammation and is insensitive to steroid treatment or cyclooxygenase (COX) inhibition. BAL fluid from ozone exposed mice mimicked the effects of in vivo ozone exposure that were associated with marked increases in oxidized lipids. 20-HETE plays a pivotal role in mediating acute ozone-induced AHR

Identification of Small Molecule Inhibitors of Pseudomonas aeruginosa Exoenzyme S Using a Yeast Phenotypic Screen

Pseudomonas aeruginosa is an opportunistic human pathogen that is a key factor in the mortality of cystic fibrosis patients, and infection represents an increased threat for human health worldwide. Because resistance of Pseudomonas aeruginosa to antibiotics is increasing, new inhibitors of pharmacologically validated targets of this bacterium are needed. Here we demonstrate that a cell-based yeast phenotypic assay, combined with a large-scale inhibitor screen, identified small molecule inhibitors that can suppress the toxicity caused by heterologous expression of selected Pseudomonas aeruginosa ORFs. We identified the first small molecule inhibitor of Exoenzyme S (ExoS), a toxin involved in Type III secretion. We show that this inhibitor, exosin, modulates ExoS ADP-ribosyltransferase activity in vitro, suggesting the inhibition is direct. Moreover, exosin and two of its analogues display a significant protective effect against Pseudomonas infection in vivo. Furthermore, because the assay was performed in yeast, we were able to demonstrate that several yeast homologues of the known human ExoS targets are likely ADP-ribosylated by the toxin. For example, using an in vitro enzymatic assay, we demonstrate that yeast Ras2p is directly modified by ExoS. Lastly, by surveying a collection of yeast deletion mutants, we identified Bmh1p, a yeast homologue of the human FAS, as an ExoS cofactor, revealing that portions of the bacterial toxin mode of action are conserved from yeast to human. Taken together, our integrated cell-based, chemical-genetic approach demonstrates that such screens can augment traditional drug screening approaches and facilitate the discovery of new compounds against a broad range of human pathogens

The clinico-radiological paradox of cognitive function and MRI burden of white matter lesions in people with multiple sclerosis: a systematic review and meta-analysis.

Moderate correlation exists between the imaging quantification of brain white matter lesions and cognitive performance in people with multiple sclerosis (MS). This may reflect the greater importance of other features, including subvisible pathology, or methodological limitations of the primary literature.To summarise the cognitive clinico-radiological paradox and explore the potential methodological factors that could influence the assessment of this relationship.Systematic review and meta-analysis of primary research relating cognitive function to white matter lesion burden.Fifty papers met eligibility criteria for review, and meta-analysis of overall results was possible in thirty-two (2050 participants). Aggregate correlation between cognition and T2 lesion burden was r = -0.30 (95% confidence interval: -0.34, -0.26). Wide methodological variability was seen, particularly related to key factors in the cognitive data capture and image analysis techniques.Resolving the persistent clinico-radiological paradox will likely require simultaneous evaluation of multiple components of the complex pathology using optimum measurement techniques for both cognitive and MRI feature quantification. We recommend a consensus initiative to support common standards for image analysis in MS, enabling benchmarking while also supporting ongoing innovation

Cultural heritage management from traditional methods to digital systems: A review from bim to digital twin

In each phase of work, the client should be able to analyze, assess, and manage project quality according to their specific needs. Traditionally, this verification and control process is manual, relying on drawings, images, and renderings to evaluate design quality and alignment with client expectations. However, when requirements change, it becomes challenging to ensure the project still meets the client's demands. Digitization processes enhance collaboration between contractors and designers through analysis and control tools that facilitate data sharing and ensure compliance with specifications. Despite the lack of traditional management data making, it difficult to quantify economic benefits precisely, digitization coupled with facilities management (FM) has proven advantages. Real-time access to complete and accurate information optimizes activities and saves time otherwise spent searching for necessary data. The research aims to review the evolution of building heritage management from traditional methods to digitization systems, highlighting the key differences these new systems bring to existing buildings, whether historic or simply old

A comprehensive research study on digital Tools in building renovation

Digital technologies are having a significant impact, it is challenging to keep up with their rapid evolution. Along with the other challenges we face, the preservation of cultural heritage and historical buildings must be prioritised. It is therefore necessary to explore and understand how we can create an effective link between the restoration of historic buildings and the constantly evolving environment of digital technologies. The article deals with a critical analysis of digital tools used in the renovation of historic buildings with a specific focus on Building Information Modelling (BIM) technologies. The aim of this study is to provide a comprehensive overview of the current state of digital tools in the context of the renovation of historic buildings and to reveal trends in the use of BIM technologies of historic buildings. The research explores in which years in which the idea of BIM in conjunction with renovation came to the fore. It focuses on specific dimensions that have been actively used in conjunction with the restoration of historic buildings and identifies which dimension is used most frequently

S-Chord: using symmetry to improve lookup efficiency in Chord

Chord is one of the simplest peer-to-peer systems that addresses the issue of efficient data location. Despite its simplicity, one of its main limitations remains the asymmetric organization of its routing. This leads to problems like inability to make in-place notifications of routing entry changes, and incapacity to support symmetric applications and to efficiently exploit network proximity. As a solution to this limitation, we propose S-Chord, an extension to Chord. In S-Chord the routing is organized in a symmetric manner, and the circular search space can be walked through bidirectionally. This results, for the worst-case, in an improvement of lookup efficiency of 25%, compared to Chord with the same size routing table. Furthermore, on average, assuming a uniform distribution of queries, S-Chord results in a 10% improvement. To test our theoretical results we implemented the S-Chord lookup algorithm and applied it to different networks.Anglai