MOESM2 of Aripiprazole once-monthly as maintenance treatment for bipolar I disorder: a 52-week, multicenter, open-label study

Additional file 2: Table S2. Change from baseline to week 52 in extrapyramidal symptoms scales during AOM 400 maintenance phase

MOESM1 of Aripiprazole once-monthly as maintenance treatment for bipolar I disorder: a 52-week, multicenter, open-label study

Additional file 1: Table S1. Demographic characteristics of study population

Relationship between response to aripiprazole once-monthly and paliperidone palmitate on work readiness and functioning in schizophrenia: A post-hoc analysis of the QUALIFY study

<div><p>Schizophrenia is a chronic disease with negative impact on patients’ employment status and quality of life. This post-hoc analysis uses data from the QUALIFY study to elucidate the relationship between work readiness and health-related quality of life and functioning. QUALIFY was a 28-week, randomized study (NCT01795547) comparing the treatment effectiveness of aripiprazole once-monthly 400 mg and paliperidone palmitate once-monthly using the Heinrichs-Carpenter Quality-of-Life Scale as the primary endpoint. Also, patients’ capacity to work and work readiness (Yes/No) was assessed with the Work Readiness Questionnaire. We categorized patients, irrespective of treatment, by work readiness at baseline and week 28: No to Yes (n = 41), Yes to Yes (n = 49), or No at week 28 (n = 118). Quality-of-Life Scale total, domains, and item scores were assessed with a mixed model of repeated measures. Patients who shifted from No to Yes in work readiness showed robust improvements on Quality-of-Life Scale total scores, significantly greater than patients not ready to work at week 28 (least squares mean difference: 11.6±2.6, p<0.0001). Scores on Quality-of-Life Scale instrumental role domain and items therein–occupational role, work functioning, work levels, work satisfaction–significantly improved in patients shifting from No to Yes in work readiness (vs patients No at Week 28). Quality-of-Life Scale total scores also significantly predicted work readiness at week 28. Overall, these results highlight a strong association between improvements in health-related quality of life and work readiness, and suggest that increasing patients’ capacity to work is an achievable and meaningful goal in the treatment of impaired functioning in schizophrenia.</p></div

Predictability of QLS total and CGI-S scores on work readiness.

<p>Parameter estimates of the effects of QLS or CGI-S scores at the visits shown (univariate models) on work readiness at week 28 (outcome = yes). Standardized values of QLS and CGI-S absolute scores were used with baseline status of readiness to work as covariate.</p

Patient demographics and baseline characteristics in patients categorized by shifts from baseline to week 28 in work readiness (WoRQ item 8).

<p>Patient demographics and baseline characteristics in patients categorized by shifts from baseline to week 28 in work readiness (WoRQ item 8).</p

Improvements in QLS total and QLS domains by shifts in work readiness.

<p>Changes in QLS total and QLS domain scores at week 28 categorized by shifts from baseline to week 28 in work readiness (WoRQ item 8) in all patients. Least squares mean (LSM) changes from baseline to week 28 are analyzed with MMRM in the full analysis set (FAS). *p<0.05, and **p<0.01, ***p<0.001, and ****p<0.0001 indicate significant differences vs the patients rated not ready to work at week 28. Error bars indicate standard error (SE) of the LSM.</p

Improvements in QLS items by shifts in work readiness.

<p>Changes in QLS item scores at week 28 categorized by shifts from baseline to week 28 in work readiness (WoRQ item 8) in all patients. Least squares mean (LSM) changes from baseline to week 28 are analyzed with MMRM in the full analysis set (FAS). *p<0.05 and **p<0.01, and ***p<0.001 indicate differences vs the patients rated not ready to work at week 28. Error bars indicate standard error (SE) of the LSM.</p

Overview of the Heinrichs-Carpenter Quality of Life Scale (QLS) and Work Readiness Questionnaire (WoRQ).

<p>Overview of the Heinrichs-Carpenter Quality of Life Scale (QLS) and Work Readiness Questionnaire (WoRQ).</p