Overview of reported adverse drug reactions of the hepatobiliary system reported by health professionals in the Republic of Croatia from 2005 to 2013

Praćenje nuspojava lijekova važno je pitanje prilikom praćenja sigurnosti primjene lijeka. Farmakovigilancija je disciplina koja obuhvaća sve radnje oko praćenja štetnih učinaka lijeka. Hepatotoksične reakcije postaju sve važniji javnozdravstveni problem. Upravo su hepatotoksične reakcije bile drugi po redu uzrok povlačenja lijekova zbog nuspojava u EU od 2002. do 2011. Većina tih reakcija nepredvidiva je i nije ovisna o dozi, stoga je važno pratiti takve reakcije nakon odobravanja lijeka. Liječenje katkada može biti komplicirano ili čak i nemoguće. Do danas su otkriveni signali koji, ako su uočeni tijekom kliničkog ispitivanja mogu ukazati na lijek s potencijalom za razvoj ozbiljnog lijekom uzrokovanog oštećenja jetre. U RH su od 2005. do 2013. godine prijavljene 202 sumnje na nuspojave lijekova na hepatobilijarni sustav od strane zdravstvenih djelatnika. Među reakcijama uglavnom su se isticala povišenja jetrenih enzima. Među lijekovima pod sumnjom najčešće su bili lijekovi iz ATK skupine N (lijekovi s djelovanjem na živčani sustav), a odmah iza njih ATK skupina C (kardiovaskularni sustav). Za detaljniju analizu i identifikaciju slučajeva lijekom uzrokovanog oštećenja jetre bilo bi potrebno kod potencijalnih slučajeva zatražiti dodatne podatke te ih ocijeniti prema RUCAM skali.Monitoring adverse drug reactions is an important issue when assessing the safety of the drug. Pharmacovigilance is a discpiline that includes all activities of monitoring the adverse effects of a drug. Hepatotoxic reactions are an important public health problem. Hepatotoxic reactions were the second most common reason for the withdrawl of drugs due to adverse reactions in the EU from 2002 to 2011. Most of the hepatotoxic reactions are unpredictable and dose-unrelated, therefore it is important to monitor such reactions after the approval of the drug. Treatment can sometimes be complicated or even impossible. Until today it has been discovered that signals if observed during clinical trials may indicate a drug with the potential for the development of severe drug-induced liver injury. There were 202 reports about suspected adverse drug reactions of hepatobiliary system reported by health professionals in the Republic of Croatia from 2005 to 2013. Among the reactions, the most common were elevated liver enzymes. Most commonly reported suspected drugs were from the ATC group N (drugs with an effect on the nervous system) and in second place from the ATC group C (cardiovascular system). For a more detailed analysis and identification of cases of severe drug-induced liver injury it would be required to collect additional data in potential cases and to reassess them according to RUCAM method

Overview of reported adverse drug reactions of the hepatobiliary system reported by health professionals in the Republic of Croatia from 2005 to 2013

Praćenje nuspojava lijekova važno je pitanje prilikom praćenja sigurnosti primjene lijeka. Farmakovigilancija je disciplina koja obuhvaća sve radnje oko praćenja štetnih učinaka lijeka. Hepatotoksične reakcije postaju sve važniji javnozdravstveni problem. Upravo su hepatotoksične reakcije bile drugi po redu uzrok povlačenja lijekova zbog nuspojava u EU od 2002. do 2011. Većina tih reakcija nepredvidiva je i nije ovisna o dozi, stoga je važno pratiti takve reakcije nakon odobravanja lijeka. Liječenje katkada može biti komplicirano ili čak i nemoguće. Do danas su otkriveni signali koji, ako su uočeni tijekom kliničkog ispitivanja mogu ukazati na lijek s potencijalom za razvoj ozbiljnog lijekom uzrokovanog oštećenja jetre. U RH su od 2005. do 2013. godine prijavljene 202 sumnje na nuspojave lijekova na hepatobilijarni sustav od strane zdravstvenih djelatnika. Među reakcijama uglavnom su se isticala povišenja jetrenih enzima. Među lijekovima pod sumnjom najčešće su bili lijekovi iz ATK skupine N (lijekovi s djelovanjem na živčani sustav), a odmah iza njih ATK skupina C (kardiovaskularni sustav). Za detaljniju analizu i identifikaciju slučajeva lijekom uzrokovanog oštećenja jetre bilo bi potrebno kod potencijalnih slučajeva zatražiti dodatne podatke te ih ocijeniti prema RUCAM skali.Monitoring adverse drug reactions is an important issue when assessing the safety of the drug. Pharmacovigilance is a discpiline that includes all activities of monitoring the adverse effects of a drug. Hepatotoxic reactions are an important public health problem. Hepatotoxic reactions were the second most common reason for the withdrawl of drugs due to adverse reactions in the EU from 2002 to 2011. Most of the hepatotoxic reactions are unpredictable and dose-unrelated, therefore it is important to monitor such reactions after the approval of the drug. Treatment can sometimes be complicated or even impossible. Until today it has been discovered that signals if observed during clinical trials may indicate a drug with the potential for the development of severe drug-induced liver injury. There were 202 reports about suspected adverse drug reactions of hepatobiliary system reported by health professionals in the Republic of Croatia from 2005 to 2013. Among the reactions, the most common were elevated liver enzymes. Most commonly reported suspected drugs were from the ATC group N (drugs with an effect on the nervous system) and in second place from the ATC group C (cardiovascular system). For a more detailed analysis and identification of cases of severe drug-induced liver injury it would be required to collect additional data in potential cases and to reassess them according to RUCAM method

Joint Observation of the Galactic Center with MAGIC and CTA-LST-1

MAGIC is a system of two Imaging Atmospheric Cherenkov Telescopes (IACTs), designed to detect very-high-energy gamma rays, and is operating in stereoscopic mode since 2009 at the Observatorio del Roque de Los Muchachos in La Palma, Spain. In 2018, the prototype IACT of the Large-Sized Telescope (LST-1) for the Cherenkov Telescope Array, a next-generation ground-based gamma-ray observatory, was inaugurated at the same site, at a distance of approximately 100 meters from the MAGIC telescopes. Using joint observations between MAGIC and LST-1, we developed a dedicated analysis pipeline and established the threefold telescope system via software, achieving the highest sensitivity in the northern hemisphere. Based on this enhanced performance, MAGIC and LST-1 have been jointly and regularly observing the Galactic Center, a region of paramount importance and complexity for IACTs. In particular, the gamma-ray emission from the dynamical center of the Milky Way is under debate. Although previous measurements suggested that a supermassive black hole Sagittarius A* plays a primary role, its radiation mechanism remains unclear, mainly due to limited angular resolution and sensitivity. The enhanced sensitivity in our novel approach is thus expected to provide new insights into the question. We here present the current status of the data analysis for the Galactic Center joint MAGIC and LST-1 observations

Overview of reported adverse drug reactions of the hepatobiliary system reported by health professionals in the Republic of Croatia from 2005 to 2013

Praćenje nuspojava lijekova važno je pitanje prilikom praćenja sigurnosti primjene lijeka. Farmakovigilancija je disciplina koja obuhvaća sve radnje oko praćenja štetnih učinaka lijeka. Hepatotoksične reakcije postaju sve važniji javnozdravstveni problem. Upravo su hepatotoksične reakcije bile drugi po redu uzrok povlačenja lijekova zbog nuspojava u EU od 2002. do 2011. Većina tih reakcija nepredvidiva je i nije ovisna o dozi, stoga je važno pratiti takve reakcije nakon odobravanja lijeka. Liječenje katkada može biti komplicirano ili čak i nemoguće. Do danas su otkriveni signali koji, ako su uočeni tijekom kliničkog ispitivanja mogu ukazati na lijek s potencijalom za razvoj ozbiljnog lijekom uzrokovanog oštećenja jetre. U RH su od 2005. do 2013. godine prijavljene 202 sumnje na nuspojave lijekova na hepatobilijarni sustav od strane zdravstvenih djelatnika. Među reakcijama uglavnom su se isticala povišenja jetrenih enzima. Među lijekovima pod sumnjom najčešće su bili lijekovi iz ATK skupine N (lijekovi s djelovanjem na živčani sustav), a odmah iza njih ATK skupina C (kardiovaskularni sustav). Za detaljniju analizu i identifikaciju slučajeva lijekom uzrokovanog oštećenja jetre bilo bi potrebno kod potencijalnih slučajeva zatražiti dodatne podatke te ih ocijeniti prema RUCAM skali.Monitoring adverse drug reactions is an important issue when assessing the safety of the drug. Pharmacovigilance is a discpiline that includes all activities of monitoring the adverse effects of a drug. Hepatotoxic reactions are an important public health problem. Hepatotoxic reactions were the second most common reason for the withdrawl of drugs due to adverse reactions in the EU from 2002 to 2011. Most of the hepatotoxic reactions are unpredictable and dose-unrelated, therefore it is important to monitor such reactions after the approval of the drug. Treatment can sometimes be complicated or even impossible. Until today it has been discovered that signals if observed during clinical trials may indicate a drug with the potential for the development of severe drug-induced liver injury. There were 202 reports about suspected adverse drug reactions of hepatobiliary system reported by health professionals in the Republic of Croatia from 2005 to 2013. Among the reactions, the most common were elevated liver enzymes. Most commonly reported suspected drugs were from the ATC group N (drugs with an effect on the nervous system) and in second place from the ATC group C (cardiovascular system). For a more detailed analysis and identification of cases of severe drug-induced liver injury it would be required to collect additional data in potential cases and to reassess them according to RUCAM method

Virtuoso : Ad libitum (studenti Muzičke akademije u Zagrebu, 26.11.2020.)

Koncert iz studentskog ciklusa Virtuoso održan na Muzičkoj akademiji u Koncertnoj dvorani "Blagoje Bersa" 26.11.2020. Izvođači: studenti Muzičke akademije u Zagrebu: Tonko Marković (violončelo), Domagoj Guščić (klavir, korepetitor na Muzičkoj akademiji), Dubravko Ćepulić Polgar (čembalo), Domagoj Pećar (fagot), Laura Šturbek Kraljević (violina), Ana Biškup (violina), Janko Adamek (udaraljke), Lucija Pejković (violončelo), Barbara Cvitanović (klavir), Andrea Pedron (udaraljke), Jan Niković (klavir), Jakov Sekula (violina), Jakov Varezić (saksofon), Izabela Conev (klavir), Petar Krokar (klavir); Ansambl tradicijske glazbe: Ana Horvat (studentica etnomuzikologije), Magda Mas (studentica etnomuzikologije), Katia Šarlija (studentica muzikologije), Damjan Bakić (student glazbene pedagogije), Lucija Lazički, (studentica glazbene pedagogije), Dora Šimunić, (studentica voile), Irma Vicula Bulaja, (studentica muzikologije), Suzana Simić (studentica glazbene pedagogije), Marina Veža (studentica muzikologije), Mia Reba, (studentica muzikologije); voditelj ansambla: Joško Ćaleta. Program: 1. Antonín Dvořák: Koncert za violončelo i orkestar u h-molu, op. 104 (I. Allegro) (izvođači: Tonko Marković, Domagoj Guščić); 2. Georg Christoph Wagenseil: Triosonata u F-duru (I. Allegro – II. Andante – III. Minuetto – IV. Allegro assai) (izvođači: Dubravko Ćepulić Polgar, Domagoj Pećar, Laura Šturbek Kraljević, Ana Biškup); 3. Nebojša Jovan Živković: To the Gods of Rhythm za djembe I glas (izvođač: Janko Adamek); 4. Ludwig van Beethoven: Sonata za violončelo i klavir u A-duru, op. 69 br. 3 (I. Allegro ma non tanto) (izvođači: Lucija Pejković, Barbara Cvitanović); 5. Peter Klatzow: Dances of earth and fire za marimbu solo (izvođač: Andrea Pedron); 6. Franz Liszt: Mađarska rapsodija u a-molu, S 244, br. 13 (izvođač: Jan Niković); 7. Marc Eychenne: Cantilene et danse (izvođači: Jakov Sekula, Jakov Varezić, Izabela Conev); 8. Samuel Barber: Balada, op. 46 (izvođač: Petar Krokar); 9. Moj je dragi cara izdvorio (Kupres), Kad se budem udavati htjela (Kuterevo), Ne zna Tone ča Tonina ima (Istra), Tri djevojke išle u patrolu (Vranovci), Zumba (Lovreć) (izvođač: Ansambl tradicijske glazbe)

Virtuoso : Ad libitum (studenti Muzičke akademije u Zagrebu, 26.11.2020.)

Koncert iz studentskog ciklusa Virtuoso održan na Muzičkoj akademiji u Koncertnoj dvorani "Blagoje Bersa" 26.11.2020. Izvođači: studenti Muzičke akademije u Zagrebu: Tonko Marković (violončelo), Domagoj Guščić (klavir, korepetitor na Muzičkoj akademiji), Dubravko Ćepulić Polgar (čembalo), Domagoj Pećar (fagot), Laura Šturbek Kraljević (violina), Ana Biškup (violina), Janko Adamek (udaraljke), Lucija Pejković (violončelo), Barbara Cvitanović (klavir), Andrea Pedron (udaraljke), Jan Niković (klavir), Jakov Sekula (violina), Jakov Varezić (saksofon), Izabela Conev (klavir), Petar Krokar (klavir); Ansambl tradicijske glazbe: Ana Horvat (studentica etnomuzikologije), Magda Mas (studentica etnomuzikologije), Katia Šarlija (studentica muzikologije), Damjan Bakić (student glazbene pedagogije), Lucija Lazički, (studentica glazbene pedagogije), Dora Šimunić, (studentica voile), Irma Vicula Bulaja, (studentica muzikologije), Suzana Simić (studentica glazbene pedagogije), Marina Veža (studentica muzikologije), Mia Reba, (studentica muzikologije); voditelj ansambla: Joško Ćaleta. Program: 1. Antonín Dvořák: Koncert za violončelo i orkestar u h-molu, op. 104 (I. Allegro) (izvođači: Tonko Marković, Domagoj Guščić); 2. Georg Christoph Wagenseil: Triosonata u F-duru (I. Allegro – II. Andante – III. Minuetto – IV. Allegro assai) (izvođači: Dubravko Ćepulić Polgar, Domagoj Pećar, Laura Šturbek Kraljević, Ana Biškup); 3. Nebojša Jovan Živković: To the Gods of Rhythm za djembe I glas (izvođač: Janko Adamek); 4. Ludwig van Beethoven: Sonata za violončelo i klavir u A-duru, op. 69 br. 3 (I. Allegro ma non tanto) (izvođači: Lucija Pejković, Barbara Cvitanović); 5. Peter Klatzow: Dances of earth and fire za marimbu solo (izvođač: Andrea Pedron); 6. Franz Liszt: Mađarska rapsodija u a-molu, S 244, br. 13 (izvođač: Jan Niković); 7. Marc Eychenne: Cantilene et danse (izvođači: Jakov Sekula, Jakov Varezić, Izabela Conev); 8. Samuel Barber: Balada, op. 46 (izvođač: Petar Krokar); 9. Moj je dragi cara izdvorio (Kupres), Kad se budem udavati htjela (Kuterevo), Ne zna Tone ča Tonina ima (Istra), Tri djevojke išle u patrolu (Vranovci), Zumba (Lovreć) (izvođač: Ansambl tradicijske glazbe)

Performance of the Large-Sized Telescope prototype of the Cherenkov Telescope Array

The next-generation ground-based gamma-ray Cherenkov Telescope Array Observatory (CTAO) will consist of imaging atmospheric Cherenkov telescopes (IACTs) of three different sizes distributed in two sites. The Large-Sized Telescopes will cover the low-energy end of the CTA energy range, starting at about 20 GeV. After its first years of operation at the CTA northern site, the Large-Sized Telescope prototype (LST-1) is in the final stage of its commissioning phase, having collected a significant amount of scientific data to date.In this contribution, we present the physics performance of the telescope using low-zenith Crab Nebula observations and Monte Carlo simulations fine-tuned accordingly. We show performance figures of merit such as the energy threshold, effective area, energy and angular resolution, and sensitivity based on the standard Hillas-parameters approach and following the source-independent and dependent analysis methods. The analysis threshold is estimated at 30 GeV. The energy resolution is around 30%, and the angular resolution is 0.3 degrees at 100 GeV.The best integral sensitivity of LST-1 is about 1.1% of the Crab Nebula flux above 250 GeV for 50 hours of observations. We also show the spectral energy distribution and light curve from Crab Nebula observations, which agree with results from other IACTs and link smoothly with Fermi-LAT when considering statistical and systematic uncertainties near the energy threshold

Cross-calibration and combined analysis of the CTA-LST prototype and the MAGIC telescopes

The Cherenkov Telescope Array (CTA) will be the next generation gamma-ray observatory, which will consist of three kinds of telescopes of different sizes. Among those, the Large Size Telescope (LST) will be the most sensitive in the low energy range starting from 20 GeV. The prototype LST (LST-1) proposed for CTA was inaugurated in October 2018 in the northern hemisphere site, La Palma (Spain), and is currently in its commissioning phase. MAGIC is a system of two gamma-ray Cherenkov telescopes of the current generation, located approximately 100 m away from LST-1, that have been operating in stereoscopic mode since 2009. Since LST-1 and MAGIC can observe the same air shower events, we can compare the brightness of showers, estimated energies of gamma rays, and other parameters event by event, which can be used to cross-calibrate the telescopes. Ultimately, by performing combined analyses of the events triggering the three telescopes, we can reconstruct the shower geometry more accurately, leading to better energy and angular resolutions, and a better discrimination of the background showers initiated by cosmic rays. For that purpose, as part of the commissioning of LST-1, we performed joint observations of established gamma-ray sources with LST-1 and MAGIC. Also, we have developed Monte Carlo simulations for such joint observations and an analysis pipeline which finds event coincidence in the offline analysis based on their timestamps. In this work, we present the first detection of an astronomical source, the Crab Nebula, with combined observation of LST-1 and MAGIC. Moreover, we show results of the inter-telescope cross-calibration obtained using Crab Nebula data taken during joint observations with LST-1 and MAGIC