ICTs connecting global citizens, global dialogue and global governance. A call for needful designs

Humankind is on the transition to a supra-system of humanity, according to which social relationships – that organise the common good – are re-organised such that global challenges are kept below the threshold of a self-inflicted breakdown. In order to succeed, three conditions are imperative: (1) Global governance needs a global conscience that orients towards the protection of the common good. (2) Such global governance needs a global dialogue on the state of the common good and the ways to proceed. (3) Such a global dialogue needs global citizens able to reflect upon the current state of the common good and the ways to proceed to desired states. Each of these imperatives is about a space of possibilities. Each space nests the following one such that they altogether form the scaffolding along which institutions can emerge that realise the imperatives when proper nuclei are introduced in those spaces. Such nuclei would already support each other. However, the clue is to further their integration by Information and Communication Technologies. An information platform shall be launched that could cover any task on any of the three levels, entangled with the articulation of cooperative action from the local to the global, based on the cybersubsidiarity model. This model is devised to ensure the percolation of meaningful information throughout the different organisational levels.2019-2

Über eine Klasse polynomialer Scharen selbstadjungierter Operatoren im Hilbertraum

HEK293A cells expressing either mouse MOG (mMOG) or rat MOG (rMOG) C terminally tagged with EGFP. (DOCX 2792 kb

Neurological update: MOG antibody disease

Myelin oligodendrocyte glycoprotein (MOG) antibody disease (MOG-AD) is now recognised as a nosological entity with specific clinical and paraclinical features to aid early diagnosis. Although no age group is exempt, median age of onset is within the fourth decade of life, with optic neuritis being the most frequent presenting phenotype. Disease course can be either monophasic or relapsing, with subsequent relapses most commonly involving the optic nerve. Residual disability develops in 50–80% of patients, with transverse myelitis at onset being the most significant predictor of long-term outcome. Recent advances in MOG antibody testing offer improved sensitivity and specificity. To avoid misdiagnosis, MOG antibody testing should be undertaken in selected cases presenting clinical and paraclinical features that are felt to be in keeping with MOG-AD, using a validated cell-based assay. MRI characteristics can help in differentiating MOG-AD from other neuroinflammatory disorders, including multiple sclerosis and neuromyelitis optica. Cerebrospinal fluid oligoclonal bands are uncommon. Randomised control trials are limited, but observational open-label experience suggests a role for high-dose steroids and plasma exchange in the treatment of acute attacks, and for immunosuppressive therapies, such as steroids, oral immunosuppressants and rituximab as maintenance treatment