ICT-based innovation and its competitive outcome: the role of information intensity

Purpose Prior research highlights the vital role of Information and Communication Technologies (ICT) for innovation in response to environmental conditions. However, there is a lack of studies that analyse the determinants of ICT investments on the innovation activities of firms in relation with their impacts on the industrial and competitive dynamics using large data sets. The paper aims to discuss these issues. Design/methodology/approach In this paper, the authors investigate the effects of ICT investments on the industrial and competitive dynamics for a large and representative panel data set. All the industries are included, and lagged effects of ICT investments are studied. The model is tested on a seven-year panel (2008–2014) of 231 Italian industries using two-stage least squares instrumental-variables estimators with industry time and fixed effects. Findings The results indicate that munificent industries and higher ICT spending are interrelated facts, showing that in sectors with more growth opportunities firms invest more in ICT and this leads to higher industry concentration, greater profit dispersion and higher competitive turbulence in the sector. Also, the paper shows that SMEs can rarely take advantage of their ICT-based innovation to start high-growth phenomena. Practical implications The results suggest that ICT-based innovation may create competitive advantages that are hard to sustain over the long-term raising important implications for managers involved in ICT-enabled innovations and policy-makers involved in building programs to foster innovation. Originality/value Against the backdrop of today’s digital transformation, the paper enriches our understanding on the disruptive effects exerted by the digitalization of the innovation process and provides a base to continue the investigation of industrial changes and competitive dynamics

Direct UV observations of the circumstellar envelope of alpha Orionis

Observations were made in the IUE LWP camera, low dispersion mode, with alpha Ori being offset various distances from the center of the Long Wavelength Large Aperture along its major axis. Signal was acquired at all offset positions and is comprised of unequal components of background/dark counts, telescope-scattered light, and scattered light emanating from the extended circumstellar shell. The star is known from optical and infrared observations to possess an extended, arc-minute sized, shell of cool material. Attempts to observe this shell with the IUE are described, although the deconvolution of the stellar signal from the telescope scattered light requires further calibration effort

Merging of globular clusters within inner galactic regions. II. The Nuclear Star Cluster formation

In this paper we present the results of two detailed N-body simulations of the interaction of a sample of four massive globular clusters in the inner region of a triaxial galaxy. A full merging of the clusters takes place, leading to a slowly evolving cluster which is quite similar to observed Nuclear Clusters. Actually, both the density and the velocity dispersion profiles match qualitatively, and quantitatively after scaling, with observed features of many nucleated galaxies. In the case of dense initial clusters, the merger remnant shows a density profile more concentrated than that of the progenitors, with a central density higher than the sum of the central progenitors central densities. These findings support the idea that a massive Nuclear Cluster may have formed in early phases of the mother galaxy evolution and lead to the formation of a nucleus, which, in many galaxies, has indeed a luminosity profile similar to that of an extended King model. A correlation with galactic nuclear activity is suggested.Comment: 18 pages, 10 figures, 3 tables. Submitted to ApJ, main journa

Stem-like and highly invasive prostate cancer cells expressing CD44v8-10 marker originate from CD44-negative cells

In human prostate cancer (PCa), the neuroendocrine cells, expressing the prostate cancer stem cell (CSC) marker CD44, may be resistant to androgen ablation and promote tumor recurrence. During the study of heterogeneity of the highly aggressive neuroendocrine PCa cell lines PC3 and DU-145, we isolated and expanded in vitro a minor subpopulation of very small cells lacking CD44 (CD44neg). Unexpectedly, these sorted CD44neg cells rapidly and spontaneously converted to a stable CD44high phenotype specifically expressing the CD44v8-10 isoform which the sorted CD44high subpopulation failed to express. Surprisingly and potentially interesting, in these cells expression of CD44v8-10 was found to be induced in stem cell medium. CD44 variant isoforms are known to be more expressed in CSC and metastatic cells than CD44 standard isoform. In agreement, functional analysis of the two sorted and cultured subpopulations has shown that the CD44v8-10pos PC3 cells, resulting from the conversion of the CD44neg subpopulation, were more invasive in vitro and had a higher clonogenic potential than the sorted CD44high cells, in that they produced mainly holoclones, known to be enriched in stem-like cells. Of interest, the CD44v8-10 is more expressed in human PCa biopsies than in normal gland. The discovery of CD44v8-10pos cells with stem-like and invasive features, derived from a minoritarian CD44neg cell population in PCa, alerts on the high plasticity of stem-like markers and urges for prudency on the approaches to targeting the putative CSC

Nature of the constant factor in the relation between radial breathing mode frequency and tube diameter for single-wall carbon nanotubes

Resonance Raman scattering is used to determine the radial breathing mode (RBM) frequency (ωRBM) dependence on tube diameter (dt) for single-wall carbon nanotubes (SWNTs). We establish experimentally the ωRBM=227.0/dt as the fundamental relation for pristine SWNTs. All the other RBM values found in the literature can be explained by an upshift in frequency due mostly to van der Waals interaction between SWNTs and environment

Hygienic and dietetic guidelines for implant-supported full-arch immediate loading prostheses

Introduction: Proper oral hygiene and diet are important considerations for success in implant prosthodontics. However, detailed hygienic and dietetic guidelines for patients rehabilitated with implant-supported, immediate loading prostheses are lacking in the literature. Methods: The authors have developed a dietary and hygienic protocol for patients rehabilitated with implant-supported, full-arch, immediate loading prostheses in order to avoid occlusal overloads during osseointegration and optimize healing. Results: The dietary and hygienic guidelines provided in this paper emphasize the importance of maintaining proper oral hygiene and diet to support osseointegration and soft tissue healing during postsurgery healing periods. Conclusions: The protocol presented has been an effective instrument to obtain and maintain osseointegration in patients rehabilitated with full-arch, immediate loading prostheses

Merging of globular clusters within inner galactic regions. I. Do they survive the tidal interaction?

The main topic of this paper is the investigation of the modes of interaction of globular clusters (GCs) moving in the inner part of a galaxy. This is tackled by means of high-resolution N-body simulations, whose first results are presented in this article. Our simulations dealt with primordial very massive (order of 10^7 solar masses) GCs that were able to decay, because of dynamical friction, into the inner regions of triaxial galaxies on a time much shorter than their internal relaxation time. To check the disruptive role of both tidal forces and GC-GC collisions, we maximised the tidal interaction considering GCs on quasi-radial orbits. The available CPU resources allowed us to follow 8 oscillations of the GCs along their orbits and the main findings are: i) clusters with an initial high enough King concentration parameter (c>=1.2), preserve up to 50% of their initial mass; ii) the inner density distribution of the survived clusters keep a King model profile; iii) GC-GC collisions have a negligible effect with respect to that caused by the passage through the galactic center; iv) the orbital energy dissipation due to the tidal interaction is of the same order of that caused by dynamical friction; v) complex sub-structures like "ripples" and "clumps" formed, as observed around real clusters. These findings support the validity of the hypothesis of merging of GCs in the galactic central region, with modes that deserve further careful investigations.Comment: LaTeX 2e, AASTeX v5.x, 23 pages with 14 figures. Accepted for publication on the Astrophysical Journal. Final version with major change