Method of complex development of creative abilities of younger schoolchildren on the basis of application of associative-a synectic technologies

Необходимость развития творческих способностей у младших школьников привели к идее использования комплексного подхода, применения проблемных ситуаций в учебном процессе, включению учеников в самостоятельную поисковую деятельность.The need to develop creative abilities among junior schoolchildren led to the idea of using an integrated approach, application of problem situations in the learning process, inclusion of students in independent research activity

GLUTATION-S-TRANSPHERASE GENES POLYMORPHISM IN THE DIFFERENT ETHNIC GROUPS OF CHILDREN

The results of genotyping of blood samples of russian and buryat children on I/D polymorphism of GSTM1, GSTT1 genes by polymerase chain reaction are given. Absence of ethnic particularities in frequency deletion genotypes of GSTM1, GSTT1 genes is shown in this article

ГЕНЫ ФЕРМЕНТОВ АНТИОКСИДАНТНОЙ СИСТЕМЫ

Oxidative stress plays an important role in the pathogenesis the most of diseases. Important components of protecting cells from oxidative stress are antioxidant enzymes. Antioxidant enzymes are characterized by population differences in enzyme activity. The purpose of the study to summarize and discuss information on genetic polymorphisms of antioxidant enzymes in the most pathology. The development plays of the role of oxidative stress. Окислительный стресс играет важную роль в патогенезе значительного числа заболеваний. Важными компонентами защиты клеток от окислительного стресса являются антиоксидантные ферменты, активность которых генетически детерминирована. Распределение частот аллелей и генотипов полиморфизмов генов антиоксидантных ферментов характеризуется межэтнической дифференциацией. Противоречивы  результаты исследований взаимосвязи полиморфизмов генов антиоксидантных ферментов с патологическими состояниями у представителей разных рас и этнических групп.

Educational Environment of Pedagogical University: Integration of Communication Formats

From the standpoint of pedagogical bioethics, approaches to organise the educational environment of a pedagogical university are proposed for the effective acquisition of teaching experience by future educators. The design of the educational environment should provide an understanding of the ethical boundaries of various communication formats and an experience of performing communicative roles. The variety of these formats and roles corresponds to the variety of loci in the modern educational space

ALA16VAL POLYMORPHISM OF SUPEROXIDEDISMUTASE 2 (SOD2) GENE IN CAUCASOID TEENAGERS WITH HYPERTENSION, LIVING IN THE EASTERN SIBERIA

The article presents the analysis of distribution of alleles and genotypes of AIa16VaI polymorphism (rs4880) of superoxidedismutase 2 (SOD2) gene in Caucasoid teenagers with hypertension (n = 102) and in Caucasoid popuIation sampIing (n = 65), Iiving in the Eastern Siberia. Frequencies of aIIeIes in popuIation sampIing were AIa = 0,492 and VaI = 0,508, of genotypes - AIa/AIa = 0,277; AIa/VaI = 0,431 and VaI/VaI = 0,292. In the group of teenagers with arteriaI hypertension the frequency of aIIeIes was AIa = 0,495 and VaI = 0,505, of genotypes - AIa/AIa = 0,245; AIa/VaI = 0,500 and VaI/VaI = 0,255. There were no significant differences found at the comparison the data

FREQUENCY OF POLYMORPHISM OF ALA16VAL GENE SOD2 IN SAMPLES OF MONGOLOID AND CAUCASOID POPULATION, LIVING IN EASTERN SIBERIA

The article presents the study of superoxide dismutase 2 gene polymorphism that plays an important role in antioxidant protection of an organism. We performed genetic typing in representatives of two ethnic groups of Eastern Siberia - Buryats (Mongoloid) and Russians (Caucasoid). Alleles frequencies among Russians were Ala = 0,492; Val = 0,508; among Buryats Ala = 0,343; Val = 0,657. We compared these frequencies between the populations from Russia and from abroad (according to the results of other researches)

ETHNIC DIFFERENCE OF HEALTH DISORDERS IN INDIGENOUS ETHNIC GROUP OF BAIKAL REGION (LITERATURE REVIEW)

An analysis of the researches showed that the indigenous ethnic group of Baikal region has high level of adaptation to a place of residence in comparison with migrant. Rate and clinical manifestations of diseases in the Buryat ethnic group have significant differences from the Russian (moderate type 1 diabetes, severe reproductive disorders). Also, there are some differences of redox protection state in indigenous ethnic group of Baikal region that could be an additional biochemical marker of disease severity

ETHNO-GENETIC MARKERS OF ANTIOXIDANT SYSTEM (LITERATURE REVIEW)

Oxidative stress plays an important role in the pathogenesis a most of diseases. Important components of protecting cells from oxidative stress are antioxidant enzymes, whose activity is genetically determined, due to the presence in the structure of the alleles of genes. Antioxidant enzymes are characterized by population and individual differences in enzyme activity. The study of genetic variation in the population of the world and the history of the formation of its gene pool is one of the promising areas of modern population genetics. Genetic variability of antioxidant enzymes in the body has recently become the most attractive destination in the pathogenesis of many diseases. Due to the involvement of enzymes in the pathogenesis of antioxidant enzymes social diseases is an important implementation. Comprehensive study of the genetic polymorphisms of genes contributes to the formation of human disease susceptibility. The antioxidant system is of the person a system that blocks the formation of free radicals, highly active oxygen. Under normal physiological conditions, a small amount of oxygen is constantly converted to superoxide anions, hydrogen peroxide and hydroxyl radicals. Excessive production of these radicals is a factor of injury; compensatory mechanism is the antioxidant system. The main component of this system is a network of antioxidant enzymes (AOP): superoxide dismutase (SOD), glutathione peroxidase (GPX), catalase (CAT) and paraoxonase (PON). In this case, the activity of enzymes evolutionarily and genetically programmed to optimize the balance of oxidative processes and the activity of antioxidant defense systems. The purpose of the review is to summarize and discuss the current data on genetic polymorphisms of antioxidant enzymes in certain pathologies, the development of which plays the role of oxidative stress

NUTRITCIOGENETICS AND RISK FACTORS OF CARDIOVASCULAR DISEASE: ASSOCIATED RESEARCH IN EASTERN SIBERIA POPULATIONS

Purpose: to study nutritional habits as a risk factor of cardiovascular pathology as so as a role of apolipoprotein A1 gene in metabolism in native and alien population of Eastern Siberia. Methods: we used Kiselev questionnaire (1998) for estimation of "nutritional risk". Totally 863 adolescents were evaluated, including 445 (51,6 %) persons of the alien ethnogroup (Russian) and 418 (48,4 %) persons of the native ethnogroup (Buriat). We evaluated clinically, functionally and genetically healthy and hypertensive (having essential arterial hypertension) adolescents and compared the results. Out of 226 adolescents with essential arterial hypertension, 144 persons were from the alien ethnogroup (mean age is 16,22 ± 1,14 years) and 82 adolescents from the native ethnogroup (mean age is 16,57 ± 1,62 years). Out of 173 healthy adolescents (mean age is 15,12 ± 2,71 years), 79 (45,7 %) persons were buriats and 94 (54,3 %) persons were Russian. Ethnic data were gotten by questionnaire, which included information about nationality back to the third generation of ancestors. We studied a total genomic DNA, which was extracted from blood serum by non-enzymatic method. An amplification of DNA loci was performed by polymerase-chain reaction using an automatic thermocycler «Biometra» with «SNP-экспресс», «Litex» reagents. The results of our research indicated an imbalance of nutritional habits with domination of protein-lipid dietary compounds in adolescents of native and alien population ofEastern Siberia. We found differentiated contributions ofinsertion-deletional polymorphism of apolipoprotein A1 gene. We did no found differences of frequency response of alleles and genotypes. We found a positive linkofapolipoprotein Al gene deletion with increased level ofcholesterine, very low density lipoproteins, triglycerides as so as with elevation ofnumbers ofblood pressure indexes in the adolescents ofthe alien ethnogroup. We did not found such kind of links in adolescents of the native ethnogroup that, as we suppose, may be a reflection of the evolutionary developed nutritional stereotype with some predominance oflipid-protein dietary component. Developed through the millennia such kind ofdiet in the indigenous population of the North and Siberia is a response to cold stress and underlies formation ofthe genotype, which aimed to developing a biochemical phenotype with ability to compensate this nutritional atherogenic imbalance