“Non avere paura”: prevenire le discriminazioni attraverso l’educazione interculturale

Il contributo che proponiamo offre una riflessione sulla confusione se-mantica e sui limiti dei discorsi sulla radicalizzazione che spesso contribui-scono ad alimentare stereotipi e pregiudizi, accelerando la diffusione di paure sociali già storicamente radicate, come quelle relative alle diversità culturali e religiose. Anziché soffermarci su modi e tecniche di azioni preventive di processi (almeno mediaticamente) sopravvalutati, proponiamo che l’educa-zione interculturale sia l’approccio più fruttuoso per operare una pulizia les-sicale e concettuale, per prevenire le discriminazioni – in primis l’islamofo-bia – come mostrano i risultati del progetto PriMed-Prevenzione e intera-zione nello spazio trans-mediterraneo, per gettare le basi di legami sociali e culturali complessi e plurali. La prospettiva interdisciplinare si fonda su dif-ferenti approcci metodologici e su una variegata e recente letteratura prove-niente, in particolare, dall’ambito pedagogico, psicologico, sociologico e sto-rico

Dataset related to article "Neutrophils mediate protection in colitis and carcinogenesis by controlling bacterial invasion and IL-22 production by gdT cells"

<p>This record contains raw data related to article "<strong>Neutrophils mediate protection in colitis and carcinogenesis by controlling bacterial invasion and IL-22 production by gd T cells"</strong></p><p>Abstract</p><p>Neutrophils are the most abundant leukocytes in human blood and play a primary role in resistance against invading microorganisms and in the acute inflammatory response. However, their role in colitis and colitis-associated colorectal cancer is still under debate. Therefore, this study aims to dissect the role of neutrophils in these pathological contexts by using a rigorous genetic approach. Neutrophil-deficient mice (Csf3r-/- mice) were challenged with classic models of colitis and colitis-associated colorectal cancer and the role of neutrophils was assessed by histological, cellular and molecular analyses coupled with adoptive cell transfer and correlative analyses using human datasets. Csf3r-/- mice showed increased susceptibility to colitis and colitis-associated colorectal cancer compared to control Csf3r+/+ mice and adoptive transfer of neutrophils in Csf3r-/- mice reverted the phenotype. In colitis, Csf3r-/- mice showed increased bacterial invasion and reduced number of healing ulcers in the colon, indicating compromised regenerative capacity of epithelial cells. Neutrophils were essential for T cell polarization and IL-22 production. In patients with ulcerative colitis, the expression of CSF3R was positively correlated with IL-22 and IL-23 expression. Moreover, gene signatures associated with epithelial cell development, proliferation and antimicrobial response were enriched in CSF3Rhigh patients. Our data support a model where neutrophils mediate protection against intestinal inflammation and colitis-associated colorectal cancer by controlling the intestinal microbiota and driving the activation of an IL-22-dependent tissue repair pathway.</p><p> </p&gt