Bayesian Inference for Duplication-Mutation with Complementarity Network Models

We observe an undirected graph $G$ without multiple edges and self-loops, which is to represent a protein-protein interaction (PPI) network. We assume that $G$ evolved under the duplication-mutation with complementarity (DMC) model from a seed graph, $G_0$, and we also observe the binary forest $\Gamma$ that represents the duplication history of $G$. A posterior density for the DMC model parameters is established, and we outline a sampling strategy by which one can perform Bayesian inference; that sampling strategy employs a particle marginal Metropolis-Hastings (PMMH) algorithm. We test our methodology on numerical examples to demonstrate a high accuracy and precision in the inference of the DMC model's mutation and homodimerization parameters

A Lagrangian trajectory view on transport and mixing processes between the eye, eyewall, and environment using a high resolution simulation of Hurricane Bonnie (1998)

The transport and mixing characteristics of a large sample of air parcels within a mature and vertically sheared hurricane vortex is examined. Data from a high-resolution (2 km grid spacing) numerical simulation of "real-case" Hurricane Bonnie (1998) is used to calculate Lagrangian trajectories of air parcels in various subdomains of the hurricane (namely, the eye, eyewall, and near-environment) to study the degree of interaction (transport and mixing) between these subdomains. It is found that 1) there is transport and mixing from the low-level eye to the eyewall that carries high- Be air which can enhance the efficiency of the hurricane heat engine; 2) a portion of the low-level inflow of the hurricane bypasses the eyewall to enter the eye, that both replaces the mass of the low-level eye and lingers for a sufficient time (order 1 hour) to acquire enhanced entropy characteristics through interaction with the ocean beneath the eye; 3) air in the mid- to upper-level eye is exchanged with the eyewall such that more than half the air of the eye is exchanged in five hours in this case of a sheared hurricane; and 4) that one-fifth of the mass in the eyewall at a height of 5 km has an origin in the mid- to upper-level environment where thet(sub e) is much less than in the eyewall, which ventilates the ensemble average eyewall theta(sub e) by about 1 K. Implications of these findings to the problem of hurricane intensity forecasting are discussed

Advance Directives and End-of-Life Care: Completion, Conversations, and Concerns of Burlington Housing Authority Residents

Introduction: •An Advance Directive is a document that allows patients to declare their wishes regarding medical care and decision making should they become unable to communicate their preferences due to an accident or illness. •The Patient Self Determination Act, passed in 1991, requires that health care institutions, such as hospitals and nursing homes, inform patients of their rights to make health care decisions, the hospitals policies regarding recognition of Advance Directives, and educate the staff and community about advance care planning. •Despite the passage of this legislation, completion of Advance Directives remains low. It is estimated that less than 25% of adults nationwide have completed an Advance Directive.https://scholarworks.uvm.edu/comphp_gallery/1048/thumbnail.jp

Celluloid Scars: The Cinematic Shaping of Memories Surrounding National Traumas in Post-War China and Japan

Since the late 1940s, filmmakers in China and Japan have used cinema as a means of shaping historical memories surrounding national traumas, such as World War II, nuclear disasters, and the massive social upheaval of China's transition towards a market economy in the 1980s. This project aims to examine films as historical artifacts which serve as vectors of memory for the events they depict. The nature of these memories is not static, and they are often subject to political and ideological forces that can manipulate historical memory, with cinema being an important tool in this process

Transcranial doppler for vasospasm monitoring: a quality improvement project to understand provider utilization in an urban neurointensive care unit

Delayed cerebral ischemia (DCI) is a common complication associated with subarachnoid hemorrhage (SAH) and is strongly correlated with significant morbidity and mortality. In order to prevent the deleterious effects of this pathology, a strategy of early detection and intervention is vital. There are a variety of imaging options that are employed to achieve these objectives. These include computed tomographic (CT) angiography (CTA), CT perfusion (CTP), transcranial doppler ultrasound (TCD), and digital subtraction angiography (DSA). According to the consensus opinion, each imaging method has strengths and weaknesses. For example, CTA and CTP are minimally invasive but require radiation exposure and contrast dosing. TCD is lower in cost and invasiveness but lacks specificity and DSA although the most invasive--is considered the gold standard for both detection and treatment. At the setting in question, there did not appear to be a consistent utilization of these imaging modalities for vasospasm monitoring

Subject bias in managerial evaluation

The following research considered the influence of the sex of the manager being evaluated, the age, managerial level, educational level and sex of the subject upon the evaluation of management behavior. A five-page questionnaire presenting four examples of managerial behavior for evaluation was administered to 45 male and 133 female managers of a large corporation. Although it was hypothesized that the independent variables would account for the variance in the scores, the multivariate analyses of variance indicated that the research did not produce significant results. Results were discussed in terms of managerial training and implications for future research

The Ecstasy of Economics: the Evolution of Sergei Eisenstein\u27s the Old and the New

In my thesis, I analyze the development of the most often forgotten work by Soviet director Sergei Eisenstein ¿ The Old and the New. The production of the film from 1926 to 1929 was during a tumultuous period of economic transition during the Soviet Union when the socialist state moved from the mixed markets of the New Economic Policy (NEP) to the centralized planning of the First Five-Year Plan. The development of The Old and the New mirrors the economic period. I analyze how Eisenstein actively adapted his cinematic practice to accommodate the changing landscape of Soviet economic policy. Additionally, I explore the influence that Eisenstein\u27s work on an uncompleted film adaptation of Karl Marx\u27s Capital had on the development of his theories of montage and his completion of The Old and the New. I argue that Eisenstein\u27s theories of montage were transformed by his studying of Marx\u27s dialectical method, and, as a result, his completed version of The Old and the New differs significantly from its original conception as The General Line. Finally, I evaluate the ways in which Eisenstein sought to inspire economic development. From this I develop my theory of the ecstasy of economics. Epitomized by the most famous scene of the film the cream separator scene, Eisenstein works to infuse a sense of fervor around the idea of collectivization and development. The protagonist Marfa experiences a moment of pure bliss, while kneeling before the cream separator, which not only inspires her to transform her village, but strives to provoke the whole of the Soviet Union toward the same ecstasy of economics that Eisenstein envisioned