Celiac vagus nerve stimulation recapitulates angiotensin II-induced splenic noradrenergic activation, driving egress of CD8 effector cells

Angiotensin II (AngII) is a peptide hormone that affects the cardiovascular system, not only through typical effects on the vasculature, kidneys, and heart, but also through less understood roles mediated by the brain and the immune system. Here, we address the hard-wired neural connections within the autonomic nervous system that modulate splenic immunity. Chronic AngII infusion triggers burst firing of the vagus nerve celiac efferent, an effect correlated with noradrenergic activation in the spleen and T cell egress. Bioelectronic stimulation of the celiac vagus nerve, in the absence of other challenges and independently from afferent signals to the brain, evokes the noradrenergic splenic pathway to promote release of a growth factor mediating neuroimmune crosstalk, placental growth factor (PlGF), and egress of CD8 effector T cells. Our findings also indicate that the neuroimmune interface mediated by PlGF and necessary for transducing the neural signal into an effective immune response is dependent on α-adrenergic receptor signaling

The active optics software for the VST telescope

The VST (VLT Survey Telescope) active optics software must basically provide the analysis of the image coming from the wavefront sensor (a 10x10 subpupils Shack Hartmann device) and the calculation of primary mirror forces and secondary mirror displacements to correct the aberrations of the optical system, instrinsic or originated for thermal and gravity reasons. After the telescope commissioning the VST will be operated by ESO. In this framework, INAF-OAC staff was committed to design and realize the software in a VLT-compliant way. This will smoothen the integration, operation and maintenance of the telescope in the Paranal observatory

Numerical study of halo concentrations in dark-energy cosmologies

We study the concentration parameters, their mass dependence and redshift evolution, of dark-matter halos in different dark-energy cosmologies with constant and time-variable equation of state, and compare them with "standard'' Lambda-CDM and OCDM models. We find that previously proposed algorithms for predicting halo concentrations can be well adapted to dark-energy models. When centred on the analytically expected values, halo concentrations show a log-normal distribution with a uniform standard deviation of ~0.2. The dependence of averaged halo concentrations on mass and redshift permits a simple fit of the form (1+z) c=c0 (M/M0)^a, with a~-0.1 throughout. We find that the cluster concentration depends on the dark energy equation of state at the cluster formation redshift z_{coll} through the linear growth factor D_+(z_{coll}). As a simple correction accounting for dark-energy cosmologies, we propose scaling c0 from Lambda-CDM with the ratio of linear growth factors, c0 -> c0 D_+(z_{coll})/D_{+,Lambda-CDM}(z_{coll}).Comment: 11 pages, submitted to Astronomy & Astrophysic

Astrophysical and Cosmological Information from Large-scale sub-mm Surveys of Extragalactic Sources

We present a quantitative analysis of the astrophysical and cosmological information that can be extracted from the many important wide-area, shallow surveys that will be carried out in the next few years. Our calculations combine the predictions of the physical model by Granato et al. (2004) for the formation and evolution of spheroidal galaxies with up-to-date phenomenological models for the evolution of starburst and normal late-type galaxies and of radio sources. We compute the expected number counts and the redshift distributions of these source populations separately and then focus on proto-spheroidal galaxies. For the latter objects we predict the counts and redshift distributions of strongly lensed sources at 250, 350, 500, and 850 micron, the angular correlation function of sources detected in the surveys considered, the angular power spectra due to clustering of sources below the detection limit in Herschel and Planck surveys. An optimal survey for selecting strongly lensed proto-spheroidal galaxies is described, and it is shown how they can be easily distinguished from the other source populations. We also discuss the detectability of the imprints of the 1-halo and 2-halo regimes on angular correlation functions and clustering power spectra, as well as the constraints on cosmological parameters that can be obtained from the determinations of these quantities. The novel data relevant to derive the first sub-millimeter estimates of the local luminosity functions of starburst and late-type galaxies, and the constraints on the properties of rare source populations, such as blazars, are also briefly described.Comment: 16 pages, 10 figures. Accepted for publication on MNRA

The Atmospheric Dispersion Corrector Software for the VST

The effects of atmospheric differential refraction on astrophysical measurements are well known. In particular, as a ray of light passes through the atmosphere, its direction is altered by the effects of atmospheric refraction. The amount of this effect depends basically on the variation of the refractive index along the path of the ray. The real accuracy needed in the atmosphere model and in the calculation of the correction to be applied is of course, considerably worse, especially at large zenith angles. On the VLT Survey Telescope (VST) the use of an Atmospheric Dispersion Corrector (ADC) is foreseen at a wide zenith distance range. This paper describes the software design and implementation aspects regarding the analytical correction law discovered to correct the refraction effect during observations with VST

Imaging the first light: experimental challenges and future perspectives in the observation of the Cosmic Microwave Background Anisotropy

Measurements of the cosmic microwave background (CMB) allow high precision observation of the Last Scattering Surface at redshift $z\sim$1100. After the success of the NASA satellite COBE, that in 1992 provided the first detection of the CMB anisotropy, results from many ground-based and balloon-borne experiments have showed a remarkable consistency between different results and provided quantitative estimates of fundamental cosmological properties. During 2003 the team of the NASA WMAP satellite has released the first improved full-sky maps of the CMB since COBE, leading to a deeper insight into the origin and evolution of the Universe. The ESA satellite Planck, scheduled for launch in 2007, is designed to provide the ultimate measurement of the CMB temperature anisotropy over the full sky, with an accuracy that will be limited only by astrophysical foregrounds, and robust detection of polarisation anisotropy. In this paper we review the experimental challenges in high precision CMB experiments and discuss the future perspectives opened by second and third generation space missions like WMAP and Planck.Comment: To be published in "Recent Research Developments in Astronomy & Astrophysics Astrophysiscs" - Vol I

Gravitational lensing of extended high-redshift sources by dark matter haloes

High-redshift galaxies and quasi-stellar objects (QSOs) are most likely to be strongly lensed by intervening haloes between the source and the observer. In addition, a large fraction of lensed sources is expected to be seen in the submillimetre region, as a result of the enhanced magnification bias on the steep intrinsic number counts. We extend in three directions Blain's earlier study of this effect. First, we use a modification of the Press-Schechter mass function and detailed lens models to compute the magnification probability distribution. We compare the magnification cross-sections of populations of singular isothermal spheres and Navarro, Frenk & White (NFW) haloes and find that they are very similar, in contrast to the image-splitting statistics which were recently investigated in other studies. The distinction between the two types of density profile is therefore irrelevant for our purposes. Secondly, we discuss quantitatively the maximum magnification, \u3bcmax, that can be achieved for extended sources (galaxies) with realistic luminosity profiles, taking into account the possible ellipticity of the lensing potential. We find that \u3bcmax plausibly falls into the range 10-30 for sources of 1-10h-1 kpc effective radius at redshifts within 1-4. Thirdly, we apply our model for the lensing magnification to a class of sources following the luminosity evolution typical for a unified scheme of QSO formation. As a result of the peculiar steepness of their intrinsic number counts, we find that the lensed source counts at a fiducial wave length of 850 \u3bcm can exceed the unlensed counts by several orders of magnitude at flux densities 73 100 mJy, even with a conservative choice of the maximum magnification

The VZV/IE63-specific T cell response prevents herpes zoster in fingolimod-treated patients.

OBJECTIVE: To assess longitudinally the antiviral immune response of T cells from patients with multiple sclerosis (MS) treated with fingolimod (FTY) vs other disease-modifying treatments (DMTs). METHODS: We assessed cellular immune responses specific to influenza virus (FLU), JC virus (JCV), and varicella-zoster virus (VZV) using quantification of interferon-γ secretion by enzyme-linked immunospot in patients with MS on FTY (n = 31), including 2 with herpes zoster (HZ), natalizumab (n = 11), and other DMTs (n = 11). We used viral lysates for FLU and VZV and a pool of peptides for FLU, JCV (VP-1), and VZV (IE63). RESULTS: Besides an expected drop of T cells, we found that, proportionally to the number of CD3(+) T cells, only FTY-treated patients with MS exhibited an increased VZV/IE63-specific T cell response peaking 6 months into treatment, a response that returned to baseline after 12 and 24 months. Two FTY-treated patients developed an HZ 6 months into treatment, coinciding with an absent VZV/IE63-specific T cell response. However, cellular immune responses specific to VZV lysate, JCV, and FLU (lysate and pool of peptide epitopes) were similar between all 3 categories (FTY, natalizumab, and other DMTs) of study patients. CONCLUSIONS: FTY-treated patients with MS exhibit an increased VZV/IE63-specific cellular immune response after 6 months of treatment. FTY-treated patients who develop an HZ are not able to mount such a response, suggesting that a T cell response directed against this viral protein may be key in preventing the occurrence of HZ