6,053 research outputs found
Policies, Legislation and Organizations Related to Water in South Africa, with Special Reference to the Olifants River Basin
water resources management / river basins / water use / organizations / institutions / mapping / government / political aspects / ethnology / social status / water policy / water law / land tenure / water supply /sanitation / water users / land use / conflict / private sector / nongovernmental organizations / local government / water user associations / catchment areas / monitoring / South Africa / Olifants river basin / Steelpoort river basin
Effect of detraining on bone and muscle tissue in subjects with chronic spinal cord injury after a period of electrically-stimulated cycling: a small cohort study
Objective: To investigate adaptive changes in bone and muscle parameters in the paralysed limbs after de-training or reduced functional electrical stimulation (FES) induced cycling following high-volume FES-cycling in chronic spinal cord injury (SCI).
Subjects: Five subjects with motor-sensory complete SCI (age 38.6 years, lesion duration 11.4 years) were included. Four subjects stopped FES-cycling completely after the training phase whereas one continued reduced FES-cycling (2-3 times/week, for 30min).
Methods: Bone and muscle parameters were assessed in the legs using peripheral quantitative computed tomography at six and twelve months after cessation of high-volume FES-cycling.
Results: Gains achieved in the distal femur by high-volume FES-cycling were partly maintained at one year of detraining: 73.0% in trabecular bone mineral density (BMD), 63.8% in total BMD, 59.4% in bone mineral content and 22.1% in muscle cross-sectional area (CSAmuscle) in the thigh. The subject who continued reduced FES-cycling maintained 96.2% and 95.0% of the previous gain in total and trabecu-lar BMD, and 98.5% in CSAmuscle.
Conclusion: Bone and muscle benefits achieved by one year of high-volume FES-cycling are partly preserved after 12 months of detraining whereas reduced cycling maintains bone and muscle mass gained. This suggests that high-volume FES-cycling has clinical relevance for at least 1y after detraining
THE THABINA IRRIGATION SCHEME IN A CONTEXT OF REHABILITATION AND MANAGEMENT TRANSFER: PROSPECTIVE ANALYSIS AND LOCAL EMPOWERMENT
Resource /Energy Economics and Policy,
Long-term low-dose ketoconazole treatment in bilateral macronodular adrenal hyperplasia
Medical therapy for Cushing's syndrome due to bilateral macronodular adrenal hyperplasia (BMAH) is generally administered for a limited time before surgery. Aberrant receptors antagonists show inconsistent efficacy in the long run to prevent adrenalectomy. We present a patient with BMAH, treated for 10 years with low doses of ketoconazole to control cortisol secretion. A 48-year-old woman presented with headaches and hypertension. Investigations showed the following: no clinical signs of Cushing's syndrome; enlarged lobulated adrenals; normal creatinine, potassium, and aldosterone; normal urinary aldosterone and metanephrines; elevated urinary free cortisol and steroid metabolites; and suppressed plasma renin activity and ACTH. A screening protocol for aberrant adrenal receptors failed to show any illegitimate hormone dependence. Ketoconazole caused rapid normalisation of cortisol and ACTH that persists over 10 years on treatment, while adrenals show no change in shape or size. Ketoconazole decreases cortisol in patients with Cushing's syndrome, and may prevent adrenal overgrowth. Steroid secretion in BMAH is inefficient as compared with normal adrenals or secreting tumours and can be controlled with low, well-tolerated doses of ketoconazole, as an alternative to surgery.
LEARNING POINTS: Enlarged, macronodular adrenals are often incidentally found during the investigation of hypertension in patients harboring BMAH. Although laboratory findings include low ACTH and elevated cortisol, the majority of patients do not display cushingoid features.Bilateral adrenalectomy, followed by life-long steroid replacement, is the usual treatment of this benign condition, and alternative medical therapy is sought. Therapy based on aberrant adrenal receptors gives disappointing results, and inhibitors of steroidogenesis are not always well tolerated.However, ketoconazole at low, well-tolerated doses appeared appropriate to control adrenal steroid secretion indefinitely, while preventing adrenal overgrowth. This treatment probably constitutes the most convenient long-term alternative to surgery
Hydro-institutional mapping in the Steelpoort River Basin, South Africa
River basins / Institutions / Organizations / Private sector / Public sector / Local government / Mapping / Water resource management / Water policy / Legislation / Rural women / Constraints / Groundwater / Surface water / Water quality / Water use / Water users / Dams / Reservoirs / Large-scale systems / Irrigation management / Industrialization / Case studies / Operations / Maintenance / Canals / Conflict / Farmer-agency interactions / Policy / Water supply / Rural development
Superconductivity and charge carrier localization in ultrathin bilayers
/ (LSCO15/LCO) bilayers
with a precisely controlled thickness of N unit cells (UCs) of the former and M
UCs of the latter ([LSCO15\_N/LCO\_M]) were grown on (001)-oriented {\slao}
(SLAO) substrates with pulsed laser deposition (PLD). X-ray diffraction and
reciprocal space map (RSM) studies confirmed the epitaxial growth of the
bilayers and showed that a [LSCO15\_2/LCO\_2] bilayer is fully strained,
whereas a [LSCO15\_2/LCO\_7] bilayer is already partially relaxed. The
\textit{in situ} monitoring of the growth with reflection high energy electron
diffraction (RHEED) revealed that the gas environment during deposition has a
surprisingly strong effect on the growth mode and thus on the amount of
disorder in the first UC of LSCO15 (or the first two monolayers of LSCO15
containing one plane each). For samples grown in pure
gas (growth type-B), the first LSCO15 UC next to the SLAO
substrate is strongly disordered. This disorder is strongly reduced if the
growth is performed in a mixture of and gas
(growth type-A). Electric transport measurements confirmed that the first UC of
LSCO15 next to the SLAO substrate is highly resistive and shows no sign of
superconductivity for growth type-B, whereas it is superconducting for growth
type-A. Furthermore, we found, rather surprisingly, that the conductivity of
the LSCO15 UC next to the LCO capping layer strongly depends on the thickness
of the latter. A LCO capping layer with 7~UCs leads to a strong localization of
the charge carriers in the adjacent LSCO15 UC and suppresses superconductivity.
The magneto-transport data suggest a similarity with the case of weakly hole
doped LSCO single crystals that are in a so-called {"{cluster-spin-glass
state}"
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Linguistic Signatures of Cognitive Processes during Writing
The relationship between working memory capacity andwriting ability was examined via a linguistic analysis ofstudent essays. Undergraduate students (n = 108) wrotetimed, prompt-based essays and completed a battery ofcognitive assessments. The surface- and discourse-levellinguistic features of studentsâ essays were then analyzedusing natural language processing tools. The results indicatedthat WM capacity was related to surface-level, but notdiscourse-level features of student essays. Additionally, theresults suggest that these relationships were attenuated forstudents with high inferencing skills, as opposed to those withlower inferencing skill
Simultaneous multi-band detection of Low Surface Brightness galaxies with Markovian modelling
We present an algorithm for the detection of Low Surface Brightness (LSB)
galaxies in images, called MARSIAA (MARkovian Software for Image Analysis in
Astronomy), which is based on multi-scale Markovian modeling. MARSIAA can be
applied simultaneously to different bands. It segments an image into a
user-defined number of classes, according to their surface brightness and
surroundings - typically, one or two classes contain the LSB structures. We
have developed an algorithm, called DetectLSB, which allows the efficient
identification of LSB galaxies from among the candidate sources selected by
MARSIAA. To assess the robustness of our method, the method was applied to a
set of 18 B and I band images (covering 1.3 square degrees in total) of the
Virgo cluster. To further assess the completeness of the results of our method,
both MARSIAA, SExtractor, and DetectLSB were applied to search for (i) mock
Virgo LSB galaxies inserted into a set of deep Next Generation Virgo Survey
(NGVS) gri-band subimages and (ii) Virgo LSB galaxies identified by eye in a
full set of NGVS square degree gri images. MARSIAA/DetectLSB recovered ~20%
more mock LSB galaxies and ~40% more LSB galaxies identified by eye than
SExtractor/DetectLSB. With a 90% fraction of false positives from an entirely
unsupervised pipeline, a completeness of 90% is reached for sources with r_e >
3" at a mean surface brightness level of mu_g=27.7 mag/arcsec^2 and a central
surface brightness of mu^0 g=26.7 mag/arcsec^2. About 10% of the false
positives are artifacts, the rest being background galaxies. We have found our
method to be complementary to the application of matched filters and an
optimized use of SExtractor, and to have the following advantages: it is
scale-free, can be applied simultaneously to several bands, and is well adapted
for crowded regions on the sky.Comment: 39 pages, 18 figures, accepted for publication in A
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