Parsing the Urban Poverty Puzzle A Multi-generational Panel Study in Rio de Janeiro’s Favelas, 1968–2008

This paper describes the methodology of a longitudinal multi-generational study in the favelas (shantytowns) of Rio de Janeiro from 1968 to 2008. Major political transformations took place in Brazil during this interval: from dictatorship to ‘opening’ to democracy; major economic transformations from ‘miracle’ boom to hyperinflation and crisis, and to relative stability; and major policy changes from the removal of favelas to their upgrading and integration. However, despite the cumulative effects of these contextual changes, poverty programmes and community efforts, the favela population has continued to grow faster than the rest of the city and the number and size of the favelas has consistently increased over these decades.urbanization, Brazil, poverty, community, slums

Seven Voices From One Organization: What Does It Mean?

It would be trite to say that citizen action means different things for different people; a cliche to say that it means different things simultaneously for the same person: yet both are overwhelmingly true. Listening carefully to the members of citizen action groups -- not the organizers, staff, or wellknown leaders -- but simply the members, reveals the entire gamut of understanding and confusions; gratifications and frustrations; of hopes and fears. The mini-portraits presented below represent a cross section, members of a single citizen action organization at a single point in time. Exploratory interviews with members of similar groups in the citizen action tradition do not seem to contradict any of the patterns that emerge from this group, although there are certainly differences in degree and emphasis. Rather than using interviews randomly across organizations, it seemed stronger to present diverse views from within the same one so as to highlight the similarities and differences that emerged. The rough ordering from enthusiasm to disenchantment should not mask the strong presence of both in each interview, and the complex interaction between individual needs, personalities and political awareness

Mega-strategies for mega-cities: a project to accelerate the generation of effective social and technological innovation

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Megacities and innovative technologies

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Risk Factors for End Stage Renal Disease in Non-WT1-Syndromic Wilms Tumor

PURPOSE: We assessed risk factors for end stage renal disease in patients with Wilms tumor without known WT1 related syndromes. We hypothesized that patients with characteristics suggestive of a WT1 etiology (early onset, stromal predominant histology, intralobar nephrogenic rests) would have a higher risk of end stage renal disease due to chronic renal failure. We predicted a high risk of end stage renal disease due to progressive bilateral Wilms tumor in patients with metachronous bilateral disease. MATERIALS AND METHODS: End stage renal disease was ascertained in 100 of 7,950 nonsyndromic patients enrolled in a National Wilms Tumor Study during 1969 to 2002. Risk factors were evaluated with cumulative incidence curves and proportional hazard regressions. RESULTS: The cumulative incidence of end stage renal disease due to chronic renal failure 20 years after Wilms tumor diagnosis was 0.7%. For end stage renal disease due to progressive bilateral Wilms tumor the incidence was 4.0% at 3 years after diagnosis in patients with synchronous bilateral Wilms tumor and 19.3% in those with metachronous bilateral Wilms tumor. For end stage renal disease due to chronic renal failure stromal predominant histology had a HR of 6.4 relative to mixed (95% CI 3.4, 11.9; p<0.001), intralobar rests had a HR of 5.9 relative to no rests (95% CI 2.0, 17.3; p=0.001), and Wilms tumor diagnosis at less than 24 months had a HR of 1.7 relative to 24 to 48 months and 2.8 relative to greater than 48 months (p=0.003 for trend). CONCLUSIONS: Metachronous bilateral Wilms tumor is associated with high rates of end stage renal disease due to surgery for progressive Wilms tumor. Characteristics associated with a WT1 etiology markedly increased the risk of end stage renal disease due to chronic renal failure despite the low risk in non-WT1 syndromic cases overall

‘We are labeled as gang members, even though we are not’: belonging, aspirations and social mobility in Cartagena

This paper explores how belonging and aspirations interact to shape marginalized young Colombians’ strategies for upward social mobility. Recent literature has argued that in the context of inequality and poverty, social mobility is constrained by people’s inability to aspire to and/or achieve their aspirations. The majority of this literature is from the economics field and looks at the way poverty acts as a brake on social mobility. This paper provides an additional interdisciplinary analysis of the role of ‘belonging’ (to places and social class) in influencing aspirations of young Colombians. Findings are based on ethnographic fieldwork with young people from two marginalized neighborhoods in Cartagena. It is argued that aspirations are closely linked to belonging and the extent to which young people feel integral to or distanced from their localities. Using a Bourdieusian perspective, the paper examines how belonging is developed and how it influences behavior, orientations and future prospects. This approach generates insights into young people’s apparent low aspirations beyond the explanation of internal behavioral poverty traps. In so doing, it provides a more comprehensive understanding of how societal structures limit aspiration development and achievement

Glucocorticoid Receptor 1B and 1C mRNA Transcript Alterations in Schizophrenia and Bipolar Disorder, and Their Possible Regulation by GR Gene Variants

Abnormal patterns of HPA axis activation, under basal conditions and in response to stress, are found in individuals with schizophrenia and bipolar disorder. Altered glucocorticoid receptor (GR) mRNA and protein expression in the dorsolateral prefrontal cortex (DLPFC) in psychiatric illness have also been reported, but the cause of these abnormalities is not known. We quantified expression of GR mRNA transcript variants which employ different 5′ promoters, in 35 schizophrenia cases, 31 bipolar disorder cases and 34 controls. We also explored whether sequence variation within the NR3C1 (GR) gene is related to GR mRNA variant expression. Total GR mRNA was decreased in the DLPFC in schizophrenia cases relative to controls (15.1%, p<0.0005) and also relative to bipolar disorder cases (8.9%, p<0.05). GR-1B mRNA was decreased in schizophrenia cases relative to controls (20.2%, p<0.05), while GR-1C mRNA was decreased in both schizophrenia and bipolar disorder cases relative to controls (16.1% and 17.2% respectively, both p<0.005). A dose-dependent effect of rs10052957 genotype on GR-1B mRNA expression was observed, where CC homozygotes displayed 18.4% lower expression than TC heterozygotes (p<0.05), and 31.8% lower expression than TT homozygotes (p<0.005). Similarly, a relationship between rs6190 (R23K) genotype and GR-1C expression was seen, with 24.8% lower expression in GG homozygotes than GA heterozygotes (p<0.01). We also observed an effect of rs41423247 (Bcl1) SNP on expression of 67 kDa GRα isoform, the most abundant GRα isoform in the DLPFC. These findings suggest possible roles for the GR-1B and GR-1C promoter regions in mediating GR gene expression changes in psychotic illness, and highlight the potential importance of sequence variation within the NR3C1 gene in modulating GR mRNA expression in the DLPFC